Leptin Level in Women with Metabolic Syndrome

CLINICAL RESEARCH
Alexander V. Dreval, PhD, ScD, Irina V. Trigolosova, PhD, ScD*, Inna V. Misnikova, PhD, ScD.

The M. Vladimirsky Moscow Regional Research Clinical Institute (MONIKI), Moscow, Russian Federation

*Corresponding author: Irina V. Trigolosova PhD, ScD. The M. Vladimirsky Moscow Regional Research Clinical Institute (MONIKI). 61/2 Shepkina st, build 9, Moscow, 129110, Russian Federation. Tel: (495) 681-13-08.E-mail:trigolosova_ira@mail.ru

Published: June 25, 2013

Abstract: 

A detailed study of the dynamics of leptin in the various types of disturbances in carbohydrate metabolism could reveal its role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM).

The aim of this study was to investigate the Fasting Leptin Level (FLL) and effect of acute hyperinsulinemia during the Intravenous Glucose Tolerance Test (IVGTT) on the leptin levels in women with Insulin Resistance Syndrome (IRS).

Materials and Methods:  In total, 59 obese women (54.0 [48.5-60.0] yrs; BMI – 33.2 [29.0-37.2] kg/m²) with IRS (12 – obesity (NGT), 18 - ITG and 30 - T2DM) were observed. The IVGTT test was done only in women with impaired glucose tolerance (IGT) and T2DM. The leptin level was investigated during fasting conditions and again 120 min post glucose loading. Then the Hepatic glucose production Index (H-index) was calculated using the IVGTT data.

Results: The FLL in women with normal glucose tolerance (NGT) was almost two times greater than in women with IGT and T2DM. A negative relationship was found to exist between FLL and HbA1c in T2DM (r=0.3, p<0.05). A positive correlation (r=0.3, p<0.05) was also recorded between FLL and the H-index in compensated T2DM women (HbA1c<7%), a negative correlation (r=0.3, p<0.05) was recorded between FLL and the H-index in decompensated T2DM women (HbA1c>8%).   The leptin level significantly decreased at 120 min of IVGTT in both the IGT and T2DM groups (p<0.05).

Conclusion: The FLL depended upon the degree of glucose metabolism impairment; postprandial leptin response to the glucose load was lower in the IGT group than in the T2DM subjects.

Keywords: 
leptin, IVGTT, T2DM, IGT.
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Int J Biomed. 2013; 3(2):63-66. © 2013 International Medical Research and Development Corporation. All rights reserved.