Lipid Transport through the Fetoplacental Barrier by the Fatty Acid-Binding Proteins in Pregnant Women with Herpes Virus Infection in the third Trimester

BASIC RESEARCH
Michael T. Lucenko, PhD, ScD*, Irina A.Andrievskaya, PhD,ScD, Natalia A.Ishutina, PhD

Far Eastern Scientific Center of Physiology and Pathology of Respiration, Siberian Branch of Russian Academy of Medical Sciences Blagoveshchensk, Russian Federation

*Corresponding author: Prof. Michael T. Lucenko, PhD, ScD, Academician of RAMS, Head of Far Eastern Scientific Center of Physiology and Pathology of Respiration SB of RAMS, 95A, Gorky str., 675000, Blagoveshchensk, Russian Federation E-mail: Lucencomt@mail.ru

Abstract: 

In this study, the transport of the long chain polyunsaturated fatty acids (LCPUFAs) from the lacunar blood through the syncytiotrophoblast of the placental villous to the fetal cord blood via a saturable protein-mediated mechanism by the heart-type fatty acid-binding proteins (H-FABPs) has been examined. Exacerbation of the herpes simplex viruses (HSV-1) in the third trimester of gestation reduces the delivery of the fatty acid-binding proteins to the syncytiotrophoblast. During exacerbation of the HSV-1 infection, the selective transfer of the LCPUFAs across the syncytiotrophoblast basal plasma membrane into the fetal cord blood was observed. The supply of anti-inflammatory ω-3 PUFAs was reduced; however, the inflow of inflammatory arachidonic acid and other ω-6 PUFAs into the fetal blood was increased.

Keywords: 
fetoplacental unit; long chain polyunsaturated fatty acids; heart-type fatty acid-binding proteins; herpes virus infection.
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Int J Biomed. 2012; 2(4):296-299. © 2012 International Medical Research and Development Corporation. All rights reserved.