Autologous Bone Marrow Mesenchymal Stem Cell Transplantation in Liver of a Patient with Liver Cirrhosis: Case Report

CASE REPORT
Boyukkishi A. Agaev, MD, PhD, ScD¹; Rauf M. Agaev, MD, PhD, ScD²; Andrey G. Popandopulo, MD, PhD, ScD³; Rasim E. Jafarli, MD, PhD

¹Scientific Center of Surgery named after M.Topchubashov, Baku, Azerbaijan; ²Azerbaijan Medical University, Baku, Azerbaijan; ³V. K. Gusak State Institute of Emergency and Reconstructive Surgery  of NAMS, the International Center of Biotechnology ”Biostem”, Donetsk, Ukraine

*Corresponding author: Rasim E. Jafarli, MD, PhD. Azerbaijan Medical University, Baku, Azerbaijan E-mail:  dr-jafarli@mail.ru

Published: March 25, 2015. DOI: 10.21103/Article5(1)_CRep

Abstract: 

This report presents a clinical case describing successful endovascular transplantation of autologous bone marrow mesenchymal stem cells (MSCs) into liver of a patient with liver cirrhosis.

Keywords: 
mesenchymal stem cells; transplantation; liver cirrhosis.
References: 
  1. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380(9859):2197-223.
  2. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380(9859):2095-128.
  3. Masson S, Harrison DJ, Plevris JN, Newsome PN. Potential of hematopoietic stem cell therapy in hepatology: a critical review. Stem cells 2004; 22(6): 897-907.
  4. Am Esch JS 2nd, Knoefel WT, Klein M, Ghodsizad A, Fuerst G, Poll LW, et al. Portal application of autologous CD133+ bone marrow cells to the liver: a novel concept to support hepatic regeneration. Stem Cells 2005; 23(4): 463-70.
  5. Fujii H1, Hirose T, Oe S, Yasuchika K, Azuma H, Fujikawa T, et al. Contribution of bone marrow cells to liver regeneration after partial hepatectomy in mice. J Hepatol 2002; 36(5): 653-9.
  6. Kakinuma S1, Tanaka Y, Chinzei R, Watanabe M, Shimizu-Saito K, Hara Y, et al. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells 2003; 21(2):217-27.
  7. Kharaziha P, Hellström PM, Noorinayer B, Farzaneh F, Aghajani K, Jafari F, et al. Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial. Eur J Gastroenterol Hepatol 2009; 21(10):1199–205.
  8. Wei X1, Yang X, Han ZP, Qu FF, Shao L, Shi YF. Mesenchymal stem cells: a new trend for cell therapy. Acta Pharmacol Sin 2013; 34(6):747-54.

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Int J Biomed. 2015; 5(1):41-43. © 2015 International Medical Research and Development Corporation. All rights reserved.