Advanced Oxidation Protein Products and the CLOCK 3111T/C Single Nucleotide Polymorphism in Menopausal Women with Insomnia

ORIGINAL ARTICLE
Natalya V. Semenova, Irina M. Madaeva, Anastasiya S. Brichagina, Olga A. Nikitina, Sergey I. Kolesnikov, Lyubov I. Kolesnikova

 
International Journal of Biomedicine. 2020;10(4):352-356.
DOI: 10.21103/Article10(4)_OA4
Originally published December 10, 2020

Abstract: 

Background: The aim of this study was to assess the dependence of advanced oxidation protein products (AOPPs) levels on the genotype of the CLOCK 3111T/C SNP in Caucasian menopausal women with and without insomnia.
Methods and Results: The study involved 105 Caucasian menopausal women volunteers aged between 45 and 60 years. The Pittsburgh Sleep Quality Index, PSQI, Insomnia Severity Index (ISI), and Epworth Sleepiness Scale (ESS) were employed. The study of the CLOCK 3111T/C SNP (rs1801260) was performed by PCR. The blood level of advanced oxidation protein products (AOPPs) was detected by IEMA. Based on the results of a clinical-anamnestic examination, the women were divided into two groups: the main (with insomnia) and the control (without insomnia). Given the small number of women carrying the CC genotype of the CLOCK 3111T/C SNP, the СС carriers and TC carriers were combined into one group as the carriers of the minor 3111C allele.
There were no statistically significant differences in the AOPP levels between carriers of different genotypes (TT genotype and TC+CC genotypes) in controls and patients. A comparative analysis of AOPP levels in the women of the main and control groups showed higher AOPP levels in women with insomnia carrying the TT genotype than in the control of the same genotype (P=0.013).
Conclusion: Insomnia in menopausal women is associated with increased protein oxidation only in carriers of the TT genotype of the CLOCK 3111T/C SNP.

Keywords: 
CLOCK 3111T/C SNP • protein oxidation • insomnia • menopause
References: 
  1. Eckel-Mahan K, Sassone-Corsi P. Metabolism and the circadian clock converge. Physiol Rev. 2013 Jan;93(1):107-35. doi: 10.1152/physrev.00016.2012. 
  2. Lowrey PL, Takahashi JS. Genetics of the mammalian circadian system: photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Annu Rev Genet 34: 533–562, 2000.
  3. Wennberg AM, Canham SL, Smith MT, Spira AP. Optimizing sleep in older adults: treating insomnia. Maturitas. 2013 Nov;76(3):247-52. doi: 10.1016/j.maturitas.2013.05.007. 
  4. Feng D, Lazar MA. Clocks, metabolism, and the epigenome. Mol Cell. 2012 Jul 27;47(2):158-67. doi: 10.1016/j.molcel.2012.06.026. 
  5. Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, Feng Y, Liu W, Yu F. A review of sleep disorders and melatonin. Neurol Res. 2017 Jun;39(6):559-565. doi: 10.1080/01616412.2017.1315864. 
  6. García JJ, López-Pingarrón L, Almeida-Souza P, Tres A, Escudero P, García-Gil FA, Tan DX, Reiter RJ, Ramírez JM, Bernal-Pérez M. Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review. J Pineal Res. 2014 Apr;56(3):225-37. doi: 10.1111/jpi.12128. 
  7. Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol. 2015;4:180-3. doi: 10.1016/j.redox.2015.01.002. 
  8. Reimund E. The free radical flux theory of sleep. Med Hypotheses. 1994 Oct;43(4):231-3. doi: 10.1016/0306-9877(94)90071-x.
  9. Gopalakrishnan A, Ji LL, Cirelli C. Sleep deprivation and cellular responses to oxidative stress. Sleep. 2004 Feb 1;27(1):27-35. doi: 10.1093/sleep/27.1.27.
  10. Mathangi DC, Shyamala R, Subhashini AS. Effect of REM sleep deprivation on the antioxidant status in the brain of Wistar rats. Ann Neurosci. 2012 Oct;19(4):161-4. doi: 10.5214/ans.0972.7531.190405. 
  11. Ramanathan L, Hu S, Frautschy SA, Siegel JM. Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior. Behav Brain Res. 2010 Mar 5;207(2):305-9. doi: 10.1016/j.bbr.2009.10.014.
  12. Süer C, Dolu N, Artis AS, Sahin L, Yilmaz A, Cetin A. The effects of long-term sleep deprivation on the long-term potentiation in the dentate gyrus and brain oxidation status in rats. Neurosci Res. 2011 May;70(1):71-7. doi: 10.1016/j.neures.2011.01.008.
  13. Thamaraiselvi K, Mathangi DC, Subhashini AS. Effect of increase in duration of REM sleep deprivation on lipid peroxidation. Int J Biol Med Res. 2012;3(2):1754-1759.
  14. Gulec M, Ozkol H, Selvi Y, Tuluce Y, Aydin A, Besiroglu L, Ozdemir PG. Oxidative stress in patients with primary insomnia. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jun 1;37(2):247-51. doi: 10.1016/j.pnpbp.2012.02.011. 
  15. Liang B, Li YH, Kong H. Serum paraoxonase, arylesterase activities and oxidative status in patients with insomnia. Eur Rev Med Pharmacol Sci. 2013 Sep;17(18):2517-22. 
  16. Hachul de Campos H, Brandão LC, D'Almeida V, Grego BH, Bittencourt LR, Tufik S, Baracat EC. Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia. Climacteric. 2006 Aug;9(4):312-9. doi: 10.1080/13697130600871947. 
  17. Sinha N, Dabla PK. Oxidative stress and antioxidants in hypertension-a current review. Curr Hypertens Rev. 2015;11(2):132-42. doi: 10.2174/1573402111666150529130922. 
  18. Kolesnikova LI, Darenskaya MA, Semenova NV,  Grebenkina LA, Suturina LV, Dolgikh MI, Gnusina SV. Lipid peroxidation and antioxidant protection in girls with type 1 diabetes mellitus during reproductive system development. Medicina (Kaunas, Lithuania). 2015. 51(2):107-111.
  19. Morris G, Stubbs B, Köhler CA,   Walder  K, Slyepchenko  A,  Berk  M,  Carvalho AF. The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis. Sleep Med Rev. 2018. S1087-0792(17):30152-30161.
  20. Bellanti F, Romano AD, Lo Buglio A, Castriotta V, Guglielmi G, Greco A, Serviddio G, Vendemiale G. Oxidative stress is increased in sarcopenia and associated with cardiovascular disease risk in sarcopenic obesity. Maturitas. 2018 Mar;109:6-12. doi: 10.1016/j.maturitas.2017.12.002. 
  21. Kudryavtseva AV, Krasnov GS, Dmitriev AA, Alekseev BY, Kardymon OL, Sadritdinova AF, Fedorova MS, Pokrovsky AV, Melnikova NV, Kaprin AD, Moskalev AA, Snezhkina AV. Mitochondrial dysfunction and oxidative stress in aging and cancer. Oncotarget. 2016 Jul 19;7(29):44879-44905. doi: 10.18632/oncotarget.9821. 
  22. Semenova NV, Madaeva IM, Bairova TA, Zhambalova RM, Sholokhov LF, Kolesnikova LI. Association of the melatonin circadian rhythms with clock 3111T/C gene polymorphism in Caucasian and Asian menopausal women with insomnia. Chronobiol Int. 2018 Aug;35(8):1066-1076. doi: 10.1080/07420528.2018.1456447. 
  23. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989 May;28(2):193-213. doi: 10.1016/0165-1781(89)90047-4. 
  24. Savard J, Simard S, Morin C. Insomnia. In A. Nikcevic, A. Kuczmierczyk, M. Bruch, editors. Formulation and treatment in clinical health psychology. London: Routledge; 2006.
  25. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 Dec;14(6):540-5. doi: 10.1093/sleep/14.6.540.
  26. Höhn A, König J, Grune T. Protein oxidation in aging and the removal of oxidized proteins. J Proteomics. 2013 Oct 30;92:132-59. doi: 10.1016/j.jprot.2013.01.004. 
  27. Piwowar A. [Biochemical and clinical aspects of advanced oxidation protein products in kidney diseases and metabolic disturbances]. Postepy Hig Med Dosw (Online). 2014 Feb 6;68:179-90. doi: 10.5604/17322693.1088754. [ Article in Polish}.
  28. Semenova NV, Madaeva IM, Kolesnikov SI, Solodova EI, Kolesnikova LI. Insomnia in peri- and postmenopausal women: plasma lipids, lipid peroxidation and some antioxidant system parameters. Neuropsychiatry. 2018;8(5):1452-1460. doi: 10.4172/Neuropsychiatry.1000477
  29. Semenova N, Madaeva I, Bairova T, Kolesnikov S, Kolesnikova L. Lipid peroxidation depends on the clock 3111T/C gene polymorphism in menopausal women with Insomnia. Chronobiol Int. 2019 Oct;36(10):1399-1408. doi: 10.1080/07420528.2019.1647436. 
  30. Kratz EM, Piwowar A. Melatonin, advanced oxidation protein products and total antioxidant capacity as seminal parameters of prooxidant-antioxidant balance and their connection with expression of metalloproteinases in context of male fertility. J Physiol Pharmacol. 2017 Oct;68(5):659-668.    

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Received September 23, 2020.
Accepted November 2, 2020.
©2020 International Medical Research and Development Corporation.