Bone Marrow Adipocytes and Hematology: A Literature Review

REVIEW
Nataliia A. Kriventsova, Alexander V. Shestopalov, Galina V. Tereshchenko

 
International Journal of Biomedicine. 2021;11(2):123-130.
DOI: 10.21103/Article11(2)_RA2
Originally published June 5, 2021

Abstract: 

This review focuses on the impact of bone marrow adipocytes on hematopoiesis and the development of hematological diseases. Bone marrow fat is a metabolically active organ capable of accumulating energy required for active hematopoiesis as well as of performing endocrine functions and participating in bone formation. Adipocytes can interact with the surrounding cells both directly and indirectly via cytokines and chemokines. Apart from their active involvement in the normal hematopoiesis, BMA have also been shown to play an important role in such diseases as leukemia, multiple myeloma and aplastic anemia. The role of fat cells in hematopoiesis is still unclear and not well studied, yet it is undoubtedly important, as demonstrated by the ever increasing number of publications supporting this conclusion.

Keywords: 
fat cells • hematopoiesis • leukemia • multiple myeloma • aplastic anemia
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