International Journal of Biomedicine. 2021;11(4):564-569.
Originally published December 10, 2021
The purpose of this study was to determine the features of the course of pregnancy, delivery, and the postpartum period in HIV-positive women with a high risk of HIV vertical transmission.
Methods and Results: A retrospective, longitudinal cohort study of mother-child pairs for the period from 2017 to 2019 was conducted in the Irkutsk City Perinatal Center (level III). The clinical observation group included HIV-positive women (n=213) and their newborn children with a high risk of perinatal immunodeficiency virus transmission (n=214). The findings of the conducted study demonstrated that most HIV-seropositive women with a high risk of HIV vertical transmission had an aggravated social history, a high prevalence of pelvic inflammatory diseases, and a high incidence of opportunistic and AIDS-defining conditions. Evaluation of PMTCT preventive complex showed that the target parameters in women with a high risk of HIV transmission were not reached: the first stage was performed for 49.3% of pregnant women with good ART adherence, the second stage – for 97.1% of obstetric patients, the third stage – in 100% of HIV perinatally exposed children. HIV RNA was detected in 3.7% of children, which evidences their antenatal infection.
Conclusion: Development of efficient communication with HIV-positive women aimed at preservation of their health and decrease of logistic barriers to access to medical care.
- [Express information on the epidemic situation of HIV infection as of 01.01.2020 in the Irkutsk Region]. Available from: https://aids38.ru/?page_id=35.
- Leshchenko OYa, Genich EV. [Reproductive disorders and their pathogenetic mechanisms in women with HIV]. HIV Infection and Immunosuppressive Disorders. 2019;11(4):20-29. doi: 10.22328/2077-9828-2019-11-4-20-29. [Article in Russian]
- Shugaeva SN, Savilov ED, Koshkina OG, Suzdalnitskiy AE, Chemezova NN. [Features of epidemic process of tuberculosis in the territory with high prevalence of HIV infection]. Acta Biomedica Scientifica. 2019;4(5):73-78. doi: 10.29413/ABS.2019-4.5.12. [Article in Russian]
- Bayanova TA, Kudryavtseva DP, Plotnikova YuK, Botvinkin AD. [The change in the incidence of some herpes virus infections in population with a high prevalence of HIV infection]. HIV Infection and Immunosuppressive Disorders. 2019;11(3):75-84. doi: 10.22328/2077-9828-2019-11-3-75-84. [Article in Russian]
- Bärnighausen T, Hosegood V, Timaeus IM, Newell ML. The socioeconomic determinants of HIV incidence: evidence from a longitudinal, population-based study in rural South Africa. AIDS. 2007 Nov;21 Suppl 7(Suppl 7):S29-38. doi: 10.1097/01.aids.0000300533.59483.95.
- Harling G, Bärnighausen T. The role of partners' educational attainment in the association between HIV and education amongst women in seven sub-Saharan African countries. J Int AIDS Soc. 2016 Feb 19;19(1):20038. doi: 10.7448/IAS.19.1.20038.
- Petrovа AG. [Perinatal HIV infection]. Irkutsk: ISCST;2020. [Book in Russian]
- Leonova ON, Stepanova EV, Belyakov NA. [Severe and comorbid conditions in HIV patients: An analysis of adverse outcomes]. HIV Infection and Immunosuppressive Disorders. 2017;9(1):55-64. doi: 10.22328/2077-9828-2017-9-1-55-64. [Article in Russian]
- Yastrebova EB, Samarina AV, Fertikh EK, Gutova LV. [Pediatric problems of HIV infection and solutions in Saint Petersburg]. HIV Infection and Immunosuppressive Disorders. 2019;11(1):31-37. doi: 10.22328/2077-9828-2019-11-1-31-37. [Article in Russian]
- Kravchenko EN, Yakovleva OA, Kuklina LV. [Obstetric and perinatal outcomes of preterm labor women living with HIV]. HIV Infection and Immunosuppressive Disorders. 2019;11(3):16-22. doi: 10.22328/2077-9828-2019-11-3-16-22. [Article in Russian]
- Balashova TN, Isurina GL, Skitnevskaya LV, Bard D, Tsvetkova LA, Volkova EN, et al. Study of alcohol consumption by pregnant and non-pregnant women in Russia. Acta Biomedica Scientifica. 2018;3(3):59-68. doi: 10.29413/ABS.2018-3.3.9.
- Pineles BL, Park E, Samet JM. Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. Am J Epidemiol. 2014;179(7):807-823. doi: 10.1093/aje/kwt334
- Shirley DK, Kaner RJ, Glesby MJ. Effects of smoking on non-AIDS-related morbidity in HIV-infected patients. Clin Infect Dis. 2013;57(2):275-282. doi: 10.1093/cid/cit207
- Chursina OA, Konstantinova OD, Kshnyaseva SK, Mazurovskaya OP. [Influence of tobacco smoking during pregnancy on the fetoplaceltal system and health of newborns]. Gynecology, Obstetrics and Perinatology. 2019;18(5):66-72. doi: 10.20953/1726-1678-2019-5-66-72. [Article in Russian]
- Savchenko GN, Koltsova OV. [Hardiness training for HIV-infected women]. HIV Infection and Immunosuppressive Disorders. 2020;12(3):111-119. doi: 10.22328/2077-9828-2020-12-3-111-119. [Article in Russian]
- Maryanyan AYu, Slepchenko VV, Rashidova MA, Podkameneva TV, Kolesnikova LI. [Current ideas about the specific features of vaginal microbiocenosis in HIV-positive women of reproductive age]. Akusherstvo i Ginekologiya. 2019;(12):12-17. doi: 10.18565/aig.2019.12.12-17. [Article in Russian]
- Gafurov YuT, Sundukov AV. [Clinico-laboratory specificities of the course of inflammatory diseases of the pelvic organs in HIV-infected patients]. Gynecology, Obstetrics and Perinatology. 2015;14(1):64-68. [Article in Russian]
- Leshchenko OYa, Genich EV, Darenskaya MA, Kolesnikova LI. [HIV and infertility: Neuro-endocrine and metabolic aspects]. HIV Infection and Immunosuppressive Disorders. 2020;12(4):73-80. doi: 10.22328/2077-9828-2020-12-4-73-80. [Article in Russian]
- Belyaeva E, Genich E, Leshchenko O. The Genotype Distribution of Human Papillomavirus among HIV-Infected Women Planning Pregnancy in Irkutsk, Russia. International Journal of Biomedicine. 2021;11(3):346-350. doi:10.21103/Article11(3)_OA11
- Рembrey L, Newell ML, Tovo PA; EPHN Collaborators. The management of HCV infected pregnant women and their children European paediatric HCV network. J Hepatol. 2005;43(3):515-525. doi: 10.1016/j.jhep.2005.06.002
- Kolesnikova LI, Kolesnikov SI, Darenskaya MA, Grebenkina LA, Timofeeva E, Leshenko OYa, et al. Menstrual and reproductive function in women with HIV-infection and antioxidant vitamins deficiency. J AIDS Clin Res. 2014;5(12):1-5. doi: 10.4172/2155-6113.1000382
- Mandelbrot L, Tubiana R, Le Chenedec J, Dollfus C, Faye A, Pannier E, et al. No perinatal HIV-1 transmission from women with effective antiretroviral therapy starting before conception. Clin Infect Dis. 2015;61(11):1715-1725. doi: 10.1093/cid/civ578
Received October 3, 2021.
Accepted November 9, 2021.
©2021 International Medical Research and Development Corporation.