Primary Mucinous Cystadenocarcinoma of the Testis: A Case Report and Literature Review

Labinot Shahini, Artan Elshani, Valon Cena, Vasiona Dermaku, Altina Metushi, Sefedin Muçaj

 
International Journal of Biomedicine. 2023;13(1):168-171.
DOI: 10.21103/Article13(1)_CR1
Originally published March 3, 2023

Abstract: 

Primary mucinous cystadenocarcinoma (MCA) of the testis is extremely rare, only 10 cases having been reported to date. Metastases of mucinous adenocarcinomas that have originated in different sites can mimic primary MAC and must be included in the differential diagnosis. We report a case of primary MCA of the tunica vaginalis testis in a 28-year-old patient who presented with a painless mass on the left side of the scrotum. We present the clinical and pathological characteristics to contribute to the further understanding of these rare tumors.

Keywords: 
mucinous cystadenocarcinoma • ovarian-type surface epithelial neoplasm • testicular adenocarcinoma
References: 
  1. Young RH, Scully RE. Testicular and paratesticular tumors and tumor-like lesions of ovarian common epithelial and müllerian types. A report of four cases and review of the literature. Am J Clin Pathol. 1986 Aug;86(2):146-52. doi: 10.1093/ajcp/86.2.146. 
  2. Hao C, Kang C, Kang X, Yu Z, Li T, Xue J. Primary Borderline Mucinous Testicular Tumor: A Case Report and Literature Review. Front Oncol. 2021 Mar 9;10:619774. doi: 10.3389/fonc.2020.619774. 
  3. Azuma T, Matayoshi Y, Nagase Y. Primary mucinous adenocarcinoma of the testis. Case Rep Med. 2012;2012:685946. doi: 10.1155/2012/685946. 
  4. Ulbright TM, Young RH. Primary mucinous tumors of the testis and paratestis: a report of nine cases. Am J Surg Pathol. 2003 Sep;27(9):1221-8. doi: 10.1097/00000478-200309000-00005.
  5. Celdrán JO, Rodríguez CS, Valverde FM, Compiano LO. Primary mucinous cystadenocarcinoma of the testis: An extremely rare ovarian-type surface epithelial carcinoma. J Cancer Res Ther. 2015 Jul-Sep;11(3):647. doi: 10.4103/0973-1482.143363.
  6. Iuga AC, Mull J, Batra R, Miller W. Mucinous cystadenocarcinoma of the testis: a case report. Hum Pathol. 2011 Sep;42(9):1343-7. doi: 10.1016/j.humpath.2010.11.021. 
  7. Tanriverdi O, Tarimer ML, Pak CD, Uylas S, Alkan A, Dere Y, Yazici A, Sen S, Sahin H. Management of a patient with primary mucinous testicular adenocarcinoma as a rare case with adjuvant and metastatic sequential treatments. J Oncol Pharm Pract. 2020 Sep;26(6):1520-1523. doi: 10.1177/1078155220903374.
  8. Lei H, Lai L, Xu H, Bai S, Shi M, Yang L. Primary mucinous adenocarcinoma of the testis: A case report and review of the literature. Front Oncol. 2021;10:32–34.
  9. Maruschke M, Schmidt W, Casper J, Hakenberg OW. Ovarian type surface epithelial carcinoma of the testis with delayed metastatic spread. Urol Int. 2008;81(1):119-21. doi: 10.1159/000137653. 
  10. Teo CH, Chua WJ, Consigliere DT, Raju GC. Primary intratesticular mucinous cystadenocarcinoma. Pathology. 2005 Feb;37(1):92-4. doi: 10.1080/00313020400024832. 
  11. Di Franco CA, Porru D, Viglio A, Paulli M, Rovereto B. Primary paratesticular mucinous "ovarian-type" adenocarcionoma: A rare case of scrotal tumor in a patient with history of bilateral cryptorchidism. World J Nephrol Urol. 2015;4:260–263.
  12. Rao NB, Sudhkar G, Swathi VR, Kumar AH. Mucinous adenocarcionoma of testis: A rare case report. J Evol Med Dental Sci. 2015;4:13144.
  13. KELLERT E. An ovarian type pseudomucinous cystadenoma in the scrotum. Cancer. 1959 Jan-Feb;12(1):187-90. doi: 10.1002/1097-0142(195901/02)12:1<187::aid-cncr2820120124>3.0.co;2-h. 
  14. Funada S, Yoshida T, Ito M, Kono F, Segawa T. Primary borderline mucinous tumors of the testis: a case report and literature review. Case Rep Oncol Med. 2015;2015:863745. doi: 10.1155/2015/863745. 
  15. Lin MS, Ayala AG, Ro JY. Ovarian-type tumors (Mullerian tumors) of the testis: clinicopathologic findings with recent advances. Ann Urol Oncol. 2019;2:36–45.
  16. Ali TZ, Parwani AV. Benign and Malignant Neoplasms of the Testis and Paratesticular Tissue. Surg Pathol Clin. 2009 Mar;2(1):61-159. doi: 10.1016/j.path.2008.08.007.
  17. Amin MB. Selected other problematic testicular and paratesticular lesions: rete testis neoplasms and pseudotumors, mesothelial lesions and secondary tumors. Mod Pathol. 2005 Feb;18 Suppl 2:S131-45. doi: 10.1038/modpathol.3800314. 
  18. Raspollini MR, Montagnani I, Montironi R, Lopez-Beltran A. Ovarian epithelial- stromal tumors and similar lesions in the testis. In Gynecologic and Urologic Pathology. In: Raspollini MR, Beltran AL, editors. Cambridge University Press, UK, 2019:62–83.
  19. Elliott JE, Klein JR, Drachenberg DE. Primary testicular mucinous neoplasms: case report and literature review. Can Urol Assoc J. 2010 Aug;4(4):E112-5. doi: 10.5489/cuaj.894. 
  20. Seo IY, Kim SG, Han WC, Rim JS. Paratesticular mucinous cystadenocarcinoma: metastasis from pancreatic cancer. Int J Urol. 2004 Dec;11(12):1147-9. doi: 10.1111/j.1442-2042.2004.00964.x. 
  21. Bunn R, Liu S, Stokes S, Turner J, Louie-Johnsun M. Mucinous Lung Adenocarcinoma Metastasis to Testis in a 29 Year Old-A Case Report. Urology. 2018 Aug;118:3-5. doi: 10.1016/j.urology.2018.01.016. 
  22. Kim YW, Kim JW, Kim JH, Lee J, Lee E, Kim MY, Yang HK, Chang H. Metastatic testicular tumor presenting as a scrotal hydrocele: An initial manifestation of pancreatic adenocarcinoma. Oncol Lett. 2014 Jun;7(6):1793-1795. doi: 10.3892/ol.2014.2009. 
  23. Jesus CM, Goldberg J, Camargo JL. Single testicular metastasis mimicking primary testicular neoplasm: a rare manifestation of prostate cancer. Int Braz J Urol. 2005 Jan-Feb;31(1):54-6. doi: 10.1590/s1677-55382005000100011. 
  24. Bürger T, Schildhaus HU, Inniger R, Hansen J, Mayer P, Schweyer S, Radzun HJ, Ströbel P, Bremmer F. Ovarian-type epithelial tumours of the testis: immunohistochemical and molecular analysis of two serous borderline tumours of the testis. Diagn Pathol. 2015 Jul 22;10:118. doi: 10.1186/s13000-015-0342-9. 
  25. Çoban G, Yildiz P, Tuğçe K, Ersöz C. Histopathological features of paratesticular solid tumors: 5 years experience. IKSSTD. 2020;12:130–135.
  26. Kim G, Kwon D, Na HY, Kim S, Moon KC. Mucinous Cystadenoma of the Testis: A Case Report with Immunohistochemical Findings. J Pathol Transl Med. 2017 Mar;51(2):180-184. doi: 10.4132/jptm.2016.08.30. 
  27. Dieckmann KP, Richter-Simonsen H, Kulejewski M, Ikogho R, Zecha H, Anheuser P, Pichlmeier U, Isbarn H. Testicular Germ-Cell Tumours: A Descriptive Analysis of Clinical Characteristics at First Presentation. Urol Int. 2018;100(4):409-419. doi: 10.1159/000488284.

Download Article
Received December 25, 2022.
Accepted January 25, 2023.
©2023 International Medical Research and Development Corporation.