Oxidative Stress Parameters and State of Regional Periodontal Blood Flow in Adolescents with Arterial Hypertension and Periodontal Diseases

ORIGINAL ARTICLE
Larisa R. Kolesnikova, Marina A. Darenskaya, Lyubov V. Rychkova, Anna V. Pogodina, Lyudmila A. Grebenkina, Sergey I. Kolesnikov, Lyubov I. Kolesnikova

 
International Journal of Biomedicine. 2018;8(4):301-305.   
DOI: 10.21103/Article8(4)_OA6
Originally published December 15, 2018  

Abstract: 

The aim of this research was to investigate LPO activity in adolescents with arterial hypertension (AH) and periodontal disease (PD) and to establish the relationship between LPO-AOD parameters and the state of regional periodontal blood flow.
Materials and Methods: A total of 113 adolescent boys and girls participated in the research (age range of 12 to 17 years). The participants were divided into 3 groups: a comparison group with PD, a clinical group with AH and without PD, and a clinical group with AH and PD. We estimated the plasma level of antioxidant parameters (total antioxidant activity, SOD activity, α-tocopherol and retinol) and primary/secondary products of LPO (conjugated dienes, ketodienes and conjugated trienes, and thiobarbituric acid reactive substances [TBARS]) using spectrophotometric and fluorometric methods. Doppler ultrasound was used to assess the hemodynamics of the microvasculature of the periodontium: the resistivity index (RI) and  pulsation index (PI) were calculated.
Results: our results indicate an increase of the imbalance in LPO-AOD system in patients with AH and PD. This imbalance is manifested in the accumulation of TBARS, thus decreasing the activity of antioxidant protection factors (α-tocopherol and SOD), as well as in the presence of pathological relationships between the parameters of LPO and indicators characterizing a decrease in vascular blood flow. These changes indicate the rapid involvement of LPO processes in the pathogenic mechanisms of developing structural and functional disorders of periodontal tissues in AH. These changes may be associated with a pronounced functional overload of periodontal tissues in the presence of inflammation. The changes in the velocity characteristics of blood flow in periodontal tissues in adolescents with AH are associated with increasing the toxic lipoperoxide metabolites and are important diagnostic criteria of regional hemodynamic disorders.

Keywords: 
arterial hypertension • adolescents • lipid peroxidation (LPO) • antioxidant defense (AOD) • periodontal diseases
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Received October 25, 2018.
Accepted November 19, 2018.
©2018 International Medical Research and Development Corporation.