The Results of Microbiological Investigations into Preterm Labor

ORIGINAL ARTICLE
Agamurad A. Orazmuradov, Igor N. Kostin, Sergey V. Apresyan, Anna N. Parygina, Alexandra A. Gavrilova, Gayane A. Arakelyan, Irina V. Savenkova, Aleksey A. Lukaev

 
International Journal of Biomedicine. 2019;9(2):144-149.
DOI: 10.21103/Article9(2)_OA13
Originally published June 15, 2019  

Abstract: 

The purpose of this study was to identify the relationship between the microbiological status of women and newborns, and the development of premature labor.
Materials and Methods: The study included 227 pregnant women at gestational age between 28 and 36 weeks and 6 days. All women underwent an assessment of vaginal microcenosis and the quantitative and qualitative composition of the biotope of the cervical discharge; the newborns underwent bacteriological examination of the auricle, pharynx and anus.
Results: Disturbances in the vaginal biotope were diagnosed in every second woman. We found that the shorter the gestation period, the higher the frequency of disturbances in the vaginal biotope, and the risk of premature birth at an earlier time correlates with the presence of infection in the mother. The risk of giving birth to an infected child is 4.2 times higher at birth from a mother who has disturbances in the biotope, compared to a woman with a normal biotope.

References: 
  1. Khadartseva KA, Kusibaeva RK. [The role of pregravid preparation in improving perinatal outcomes in women with inflammatory diseases of the genital tract]. Russian Journal of Woman and Child Health. 2017;(25):1934-1937. [Article in Russian].
  2. Dolgushina VF, Kurnosenko IV, Astashkina MV, Nadvigova TV. [Infectious Pathology of the vagina and the cervix in women with spontaneous preterm birth]. Ural medical journal.2017;(1):62-64. [Article in Russian].
  3. Katkova NYu, Bodrikova OI, Bezrukova IM, Guseva OI, Lebedeva NV, Pokusayeva KB, Mikhaylenko OA. [Clinical and Anamnestic Features of Different Types of Premature Birth (Retrospective Review)]. Effektivnaya Farmakoterapiya. 2017; (26):12-17. [Article in Russian].
  4. Beghini J, Giraldo PC, Linhares IM, Ledger WJ, Witkin SS. Neutrophil Gelatinase-Associated Lipocalin Concentration in Vaginal Fluid: Relation to Bacterial Vaginosis and Vulvovaginal Candidiasis. Reprod Sci. 2015;22(8):964-8. doi: 10.1177/1933719115570914.
  5. Hilbert DW, Smith WL, Chadwick SG, Toner G, Mordechai E, Adelson ME, et al. Development and Validation of a Highly Accurate Quantitative Real-Time PCR Assay for Diagnosis of Bacterial Vaginosis. J Clin Microbiol. 2016;54(4):1017-24. doi: 10.1128/JCM.03104-15.
  6. Vieira-Baptista P, Lima-Silva J, Pinto C, Saldanha C, Beires J, Martinez-de-Oliveira J, Donders G. Bacterial vaginosis, aerobic vaginitis, vaginal inflammation and major Pap smear abnormalities. Eur J Clin Microbiol Infect Dis. 2016;35(4):657-64. doi: 10.1007/s10096-016-2584-1.
  7. Vitali B, Cruciani F, Picone G, Parolin C, Donders G, Laghi L. Vaginal microbiome and metabolome highlight specific signatures of bacterial vaginosis. Eur J Clin Microbiol Infect Dis. 2015;34(12):2367-76. doi: 10.1007/s10096-015-2490-y.
  8. Wang ZL, Fu LY, Xiong ZA, Qin Q, Yu TH, Wu YT, et al. Diagnosis and microecological characteristics of aerobic vaginitis in outpatients based on preformed enzymes. Taiwan J Obstet Gynecol. 2016;55(1):40-4. doi: 10.1016/j.tjog.2015.06.012.
  9. Xiao B, Niu X, Han N, Wang B, Du P, Na R, et al. Predictive value of the composition of the vaginal microbiota in bacterial vaginosis, a dynamic study to identify recurrence-related flora. Sci Rep. 2016;6:26674. doi: 10.1038/srep26674.
  10. Petrov YuA, Galushchenko EM, Arndt IG. [Premature birth taking into account the influence  of the vaginal microbiocenosis]. Mezhdunarodnii Zhurnal Prikladnih i Fundamental'nih Sssledovanii. 2018;(11-2):384-388. [Article in Russian].
  11. Radzinsky VE, Orazmuradov AA. Early gestational age. From pregravid preparation to healthy gestation. 3rd., rev. version. M.: StatusPraesens; 2018. [In Russian].
  12. Subramaniam A, Kumar R, Cliver SP, Zhi D, Szychowski JM, Abramovici A, et al. Vaginal Microbiota in Pregnancy: Evaluation Based on Vaginal Flora, Birth Outcome, and Race.Am J Perinatol. 2016;33(4):401-8. doi: 10.1055/s-0035-1565919.
  13. Yang S, Reid G, Challis JR, Kim SO, Gloor GB, Bocking AD. Is there a role for probiotics in the prevention of preterm birth? Front Immunol. 2015;6:62. doi: 10.3389/fimmu.2015.00062.
  14. Haahr T, Ersbøll AS, Karlsen MA, Svare J, Sneider K, Hee L, et al. Treatment of bacterial vaginosis in pregnancy in order to reduce the risk of spontaneous preterm delivery - a clinical recommendation. Acta Obstet Gynecol Scand. 2016;95(8):850-60. doi: 10.1111/aogs.12933.
  15. Heczko PB, Tomusiak A, Adamski P, Jakimiuk AJ, Stefański G, Mikołajczyk-Cichońska A, et al. Supplementation of standard antibiotic therapy with oral probiotics for bacterial vaginosis and aerobic vaginitis: a randomised, double-blind, placebo-controlled trial. BMC Womens Health. 2015;15:115. doi: 10.1186/s12905-015-0246-6.
  16. Nelson DB, Hanlon AL, Wu G, Liu C, Fredricks DN. First Trimester Levels of BV-Associated Bacteria and Risk of Miscarriage Among Women Early in Pregnancy. Matern Child Health J. 2015;19(12):2682-7. doi: 10.1007/s10995-015-1790-2.
  17. Orazmuradov AA, Soyunov MA, Efendieva ZM, Lukaev AA, Gradova IE, Mukhtarova AV, Kaplina IN. Influence of Perinatal Risk Factors on Premature Labor Outcome. International Journal of Biomedicine. 2016;6(3):199-201
  18. Kuzmina TE, Pashkov VM, Klindukhov I.A. [Pregravid preparation. Modern conceptions]. Gynecology, Obstetrics and Perinatology. 2015;14(5):47–54. [Article in Russian].
  19. Pustotina OA, Akhmedova AE. [Pregravid preparation for women with a history of miscarriage]. Meditsinskiy Sovet. 2016;(4):130-136. [Article in Russian].
  20. Khamadyanov UR, Gumerova IA, Khamadyanova AU, Galimov AI, Khamadyanova SU, Tikhonova TF. [Role of genital nontransmissible infections in preterm pregnancy termination]. Russian Bulletin of Obstetrician-Gynecologist. 2016;16(6):32-37. [Article in Russian].
  21. Karapetyan TE, Muraveva VV, Ankirskaya AS, Lyubasovskaya LA, Priputnevich TV. [Treatment options for opportunistic vaginal infections during pregnancy]. Ginekologiia. 2017;19(6):11-15. [Article in Russian].
  22. Radzinskiy VE,      Orazmuradov AA,          Arakelyan VF. [Biocenosis vagina at the very early preterm labor]. Medical Herald of the South of Russia. 2014;(4):90-94. [Article in Russian].
  23. Tyutyunnik VL, Kan NE, Lomova NA. [Modern aspects of therapy of non-specific vulvovaginitis during pregnancy]. Meditsinskiy Sovet. 2018;(7):102-105. [Article in Russian].
  24. Nasioudis D, Linhares IM, Ledger WJ, Witkin SS. Bacterial vaginosis: a critical analysis of current knowledge. BJOG. 2017;124(1):61-69. doi: 10.1111/1471-0528.14209.
  25. Podgornaya AV, Makhmutkhodzhaev ASh, Mikheenko GA, Koch LI. [Management of pregnant women with recurrent bacterial vaginosis]. Modern problems of science and education. 2016(6):172. [Article in Russian].
  26. Amaya-Guio J, Viveros-Carreño DA, Sierra-Barrios EM, Martinez-Velasquez MY, Grillo-Ardila CF. Antibiotic treatment for the sexual partners of women with bacterial vaginosis. Cochrane Database Syst Rev. 2016;10:CD011701.
  27. Catallozzi M, Fraiz LD, Hargreaves KM, Zimet GD, Stanberry LR, Ratner AJ, et al. Pregnant women's attitudes about topical microbicides for the prevention and treatment of bacterial vaginosis during pregnancy. Int J STD AIDS. 2017;28(9):881-886. doi: 10.1177/0956462416679067.
  28. Liang Q, Li N, Song S, Zhang A, Li N, Duan Y. High-dose nifuratel for simple and mixed aerobic vaginitis: A single-center prospective open-label cohort study. J Obstet Gynaecol Res. 2016;42(10):1354-1360. doi: 10.1111/jog.13052.
  29. Sobel R, Sobel JD. Metronidazole for the treatment of vaginal infections. Expert Opin Pharmacother. 2015;16(7):1109-15. doi: 10.1517/14656566.2015.1035255.
  30. Orazmuradov AA, Zakharova NI, Lukaev AA, Zholobova EV. Neonatal outcomes in the postpartum period depending on perinatal risk factors, terms and mode of delivery. International Journal of Biomedicine. 2016;6(3):202-206.

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Received May 7, 2019.
Accepted June 12, 2019.
©2019 International Medical Research and Development Corporation.