Regulatory Synchronization of Hemodynamics of the Heart and Brain in Norm

Alexander G. Kruglov, Valery N. Utkin, Alexander Yu. Vasilyev, Andrey A. Kruglov

International Journal of Biomedicine. 2019;9(4):281-286.
DOI: 10.21103/Article9(4)_OA1
Originally published December 15, 2019


By catheterization, the integral indicators of synchronization and interaction of blood flows, designated as “venous and arterial boluses,” were obtained, studied and analyzed in healthy people on the pathway: right heart–lung–left heart. It has been confirmed that the complete CC of the BB from RA to the ejection from the LV has a length equal to two completed heart contraction cycles. Interaction of venous and arterial boluses, with differentiated external myocardial exposure, along the path “venous block of the heart–lung–arterial block of the heart,” forms averaged (compensated by the flexible septum) variable pressure values between the stages of intracardiac routes of BBs (unidirectional, synchronous, but spread in the space). The complex of these pressure values ​​creates an intracardiac pressure balance at the border of high- and low-energy processes of the heart. We defined the sequential dynamics of these values ​​as CMIP. Our mathematical and graphical data demonstrate the presence of direct and inversecardio-cerebral wave connections, where the waveguides are the vessels of entry and exit from the skull. We believe that CMIP is a universal, central rhythmic process, a regulator that determines the sequence and intensity of the CC phases, HR, and synchronous nervous and wave effects on brain structures. The modulating effect of CMIP on brain structures, providing some sensory-motor reactions, behavioral functions and forms of behavior, occurs outside the realm of consciousness. Our data suggest that the modulating effect of CMIP on the brain is carried out not only along the neural pathways, but also by the vascular wave structures that combine the heart and brain into a single hydrodynamic structure with phase-varying volume and configuration, as well as variable patterns of regulatory impulses

cardiac cycle • hemodynamic parameters • cardio-cerebral synchronization • ECG
  1. Kruglov AG, Gebel GYa, Vasilyev AY. Impact of Intra-Extracranial Hemodynamics on Cerebral Ischemia by Arterial Hypertension (Part 1-2). Int J Biomed. 2012;2(2):96-101.
  2. Kruglov AG, Vasilyev AY, Sherman VA. Human dynamic homeostasis control matrix in the norm with psychophysiological aspects. New York: IMRDC, 2016.
  3. Gebel GYa, Dasaev AN, Belichenko IA, Kruglov AG, Gudenko VV, Utkin VN. [Intracranial venous pressure in the norm and arterial hypertension]. Abstracts of the 7th Union Conference on Space and aerospace medicine. Kaluga,1982:184. [Abstract in Russian].
  4. Kruglov AG, Utkin VN, Vasilyev AY. The Role of Integrated Gas Compounds in Regulation of Gas Homeostasis in the Norm”. International Journal of Biomedicine. 2017; 7(3):185-191.
  5. Kruglov AG, Utkin VN, Vasilyev AY,  Sherman VA. Human Homeostatic Control Matrix in Norm. International Journal of Biomedicine. 2016;6(3):184-9.
  6. Kruglov AG, Utkin VN, Vasilyev AY. Synchronization of Wave Flows of Arterial and Venous Blood with Phases of the Cardiac Cycle in Norm: Part 1. International Journal of Biomedicine. 2018;8(2):123-128.
  7. Kruglov AG, Utkin VN, Vasilyev AY, Kruglov AA.  Synchronization of Wave Flows of Arterial and Venous Blood and Phases of the Cardiac Cycle with the Structure of the Peripheral Pulse Wave in Norm: Part 2. International Journal of Biomedicine. 2018;8(3):177-181.
  8. Kruglov AG, Utkin VN, Vasilyev AY, Kruglov AA.  Synchronization of Wave Flows of Arterial and Venous Blood and Phases of the Cardiac Cycle with the Structure of the Peripheral Pulse Wave in Norm: Part 3. International Journal of Biomedicine. 2018;8(4):288-291.
  9. Kruglov AG, Utkin VN, Vasilyev AY, Kruglov AA. Synchronization of Wave Flows of Arterial and Venous Blood and Phases of the Cardiac Cycle. (Part 4). International Journal of Biomedicine. 2019;9(2):106-110.
  10. Lightfoot A. Transport phenomena in live systems. Biomedical aspects of momentum and mass transport. M.: Mir, 1977. [in Russian].
  11. Lacey J.I. Somatic response pattering and stress: some revisions of activation theory. In: Appley MH, Trumbull R, editors. Psychological stress: Issue in research. New York: Appleton-Century-Croft; 1967:14–42.
  12. Malov YuS, Yarovenko II. Significance of the left ventricular ejection fraction in diagnosis of heart failure. Vestnik Rossiiskoi Voenno-Medicinskoi Akademii. 2018;1(61):68-74.
  13. Velden M, Juris M. Perceptial perfomans as a function of intra-cycle cardial activity. Psychophysiology. 1975;12(6):685-92.
  14. Sandman CA. Augmentation of the auditory event related potentials of the brain during diastole. Int J Psychophysiol. 1984;2(2):111-9.
  15. Sandman CA, Walker BB, Berka C. Influence of afferent cardiovascular feedback on behavior and the cortical evoked potential. In: Cacioppo JT, Petty RE (eds) Perspectives in cardiovascular psychophysiology. Guilford, New York; 1982:189–222.
  17. Sandman CA, O’Halloran JP, Isenhart R. Is there an evoked vascular response? Science. 1984;224(4655):1355-7.
  18. Weitkunat R, Cestaro V, Katkin E. Evidence for a lateralized heartbeat evoked potential. Psichophysiology. 1989;26:65.
  19. Weitkunat R, Schandry R. Motivation and heartbeat evoked potentials. J. Psychophysiol. 1990;4:33-40.
  20. Lacey JI, Lacey BC. Studies of heart rate and other bodily processes in sensorimotor behavior. In P. Obrist, A. H. Black, J. Brener, L. V. DiCara (Eds.), Cardiovascular psychophysiology. Chicago: Aldine; 1974:538-564.
  21. Lacey JI, Lacey BC. Some autonomic-central nervous system interrelationships. In P. Black (Ed.), Physiological correlates of emotion. New York: Academic Press; 1970:205-228.
  22. Lacey JI, Lacey BC. On heart rate response and behavior: a reply to Elliot. J Pers Soc Psychol. 1974;30(1):1-18.
  23. Donald DE, Shepherd JT. Sustained capacity for exercise in dogs after complete cardiac denervation. Am J Cardiol. 1964;14:853-9.
  24. Pokrovsky VM, Korotko GF. Human physiology. M. Meditsina, 2003.[In Russian].
  25. Walker BB, Walker JM. Phase relations between carotid pressure and ongoing electrocortical activity. Int J Psychophysiol. 1983;(1):65-73.
  26. Walker BB, Sandman CA. Visual evoked potentials change as heart rate and carotid pressure change. Psychophysiology. 1982;19(5):520-7.
  27. Have B, Britton B, Daniels D, Heilman K, Porges S, Halaris A. Low cardiac vagaltone index by heart rate variability differentiates bipolar from major depression. World J Biol Psychiatry. 2019;20(5):359-367. doi: 10.1080/15622975.2017.1376113.

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Received September 4, 2019.
Accepted November 11, 2019.
©2019 International Medical Research and Development Corporation.