Studying the Processes of Myocardial Remodeling in Hypertensive Patients on the Basis of Pathoanatomical Studies

BASIC RESEARCH
Aiman S. Kerimkulova, PhD*

Semey State Medical University, Semey, Kazakhstan

*Corresponding author: Aiman S. Kerimkulova PhD, Head of the Department of Outpatient Care, Semey State Medical University, 13 Shakerim str., app.112, 071400, Semey, Kazakhstan. Tel.: 7-222-56-2881 (office), 7-222-56-3346 (home), 7-777-257-0948 (cell). E-mail: k-aiman@yandex.ru

Abstract: 

Background: In the study of the arterial hypertension (AH), it is noted that remodeling occurs on both the left and right ventricles of the heart.

Methods and results: According to the postmortem autopsy of the dead, a retrospective case-control study had being conducted in the Republic of Kazakhstan in Semey city for 11 years, who had suffered from AH during the lifetime.

Conclusions: It has been revealed that hypertrophy in AH occurs not only of the left, but also of the right ventricle, up to 78.2% in the whole group; a larger part occurs in males (males: up to 81.4%, women: up to 73.7%). The majority of AH patients who died had moderate left ventricular hypertrophy (LVH) (61%), slightly higher among females (65.8%) than males (57.3%). Various degrees of LVH differences by gender in the basic parameters have been identified. It is observed that there is a unidirectional increase in the value of the left and right ventricle depending on the increases of the severity of hypertrophy. Individuals with a strong degree of the right ventricular hypertrophy (44.6%) were predominant among the AH dead patients, greater in males (49.1%) compared with females (38.2%). Differences by gender has been found according to age (P=0.006) and thickness of the wall of the right ventricle (P=0.04).

Keywords: 
pathoanatomical research; hypertension; left ventricular hypertrophy; right ventricular hypertrophy; gender.
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Int J Biomed. 2011; 1(2):97-102.© 2011 International Medical Research and Development Corporation. All rights reserved.