Contribution of Carbohydrate Metabolism Disorders to the Development of Target Organ Damage in Hypertensive Patients with Metabolic Syndrome

Nigora Z. Srojidinova

Republican Specialized Center of Cardiology, Tashkent, Uzbekistan

*Corresponding author: Nigora Z. Srojidinova, PhD, Department of Arterial Hypertension, Republican Specialized Center of Cardiology, 4, Osiyo str., 100052, Tashkent, Uzbekistan. Tel: 998-97-1040112 E-mail:


Objective: The relationship between glucose abnormality and cardiovascular and renal functions in hypertensive patients with metabolic syndrome (MetS) was examined in this study.

Methods: The population included 85 hypertensive patients with MetS. MetS is defined according to IDF, 2005 criteria. Metabolic measures included lipids, plasma insulin, glucose tolerance test, and insulin sensitivity by the homeostasis model assessment. M- and B-mode ultrasounds were used to determine left ventricular (LV) hypertrophy, endothelium-dependent vasodilation and intima media thickness.

Results: Hypertensive patients who have had either impaired glucose tolerance (IGT) and hyperinsulinemia or a combination of both have expressed a higher degree of LV hypertrophy, LV diastolic dysfunction, endothelium dysfunction and lipid disorders.

Conclusions: The presence of the IGT and hyperinsulinemia changes for the worse cardiovascular remodeling processes in hypertensive patients with MetS and it is association with high risk of target organ damage.

hypertension, metabolic syndrome.
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Int J Biomed. 2011; 1(3):132-38. © 2011 International Medical Research and Development Corporation. All rights reserved.