Efficacy and Safety of Tocilizumab in Patients with Severe Systemic Juvenile Idiopathic Arthritis

Ekaterina I. Alekseeva, PhD, ScD¹,²*, Rina V. Denisova, PhD¹, Saniya I. Valieva, PhD¹, Tatyana M. Bsarova, PhD¹, Kseniya B. Isaeva, PhD¹, Evgeniya G. Chistyakova, PhD¹, Tatyana V. Sleptsova, PhD¹, Elena V. Mitenko¹

¹Scientific Centre of Children Health of RAMS, Moscow, Russian Federation

²I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

*Corresponding author: Prof. Ekaterina I. Alekseeva, PhD, ScD, Scientific Centre of Children Health of RAMS, 2/62, Lomonosov avenue, 119991, Moscow, Russian Federation. Tel/Fax: 7-499-1340297 E-Mail: alekatya@yandex.ru


It has been observed that 10-20% of children with juvenile idiopathic arthritis (JIA) have a characteristically wide range of extra-articular manifestations. The treatment of systemic JIA with glucocorticoids and immunosuppressants has not always been effective. Significantly, interleukin-6 has been found to play an important role in the development of extra-articular manifestations and complications of the disease. Inhibition of this cytokine appears to be a promising therapeutic approach. The article presents the results of research on the effectiveness and safety of tocilizumab treatment in 39 patients with severe systemic JIA, refractory to standard immunosuppressive therapy. Tocilizumab therapy is characterized by high efficacy and safety. After six months of treatment, 50% of patients were recorded as having inactive disease status, while 57% of patients had no symptoms of the disease after 12 months. Adverse events manifested included mild to moderately severe infections, leukopenia and neutropenia. 

juvenile idiopathic arthritis; extra-articular manifestations; interleukin-6; tocilizumab therapy.
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Int J Biomed. 2011; 1(4):190-198. © 2011 International Medical Research and Development Corporation. All rights reserved.