The Effect of Peptide YY3-36 in Body Mass Regulation in Patients with Exogenous Constitutional Obesity

Yuliya Y. Vlasova, PhD¹²*, Alexander S. Ametov PhD, ScD³

¹Samara Medical University “REAVIZ”, Samara, Russian Federation

²Sigmund Freud University, Vienna, Austria

³Russian Academy of Postgraduate Medical Education, Moscow, Russian Federation

*Corresponding author: Assoc. Prof. Yuliya Y. Vlasova, PhD, Department of Clinical Medicine and Endocrinology, Samara Medical University “REAVIZ”, Samara, Russian Federation; Doctoral Program student, Sigmung Freud University. Neustiftgasse 96/1/24 A-1070, Vienna, Austria. Tel: 436765359446 Fax: 4317894098.


The article deals with PYY3-36 level in the blood serum of patients suffering from exogenous constitutional obesity and overweight, as well as its role in the process of the body mass growth. Among the 327 patients diagnosed with obesity and overweight, particularly those with Class I and II degrees of obesity (p<0.05) showed a significantly increased level of PYY3-36. The highest PYY3-36 level was observed in those with the Class II or second degree of obesity (p<0.05). Exogenous Constitutional Obesity is accompanied by a significant increase in PYY3-36 in patients with Class I and II degrees of obesity.

obesity; PYY3-36.

1. Schwartz MW, Woods SC, Porte DJr, et al. Central nervous system control of food intake. Nature 2000; 404:6778: 661-671.
2. Konturek PC, Konturek JW, Cześnikiewicz-Guzik M, et al. Neuro-hormonal control of food intake: basic mechanisms and clinical implications. J Physiol Pharmacol 2005; 56(suppl.6):5-25.
3. Sahu A. Minireview: A hypothalamic role in energy balance with special emphasis on leptin. Endocrinology 2004; 145:6:2613-2620.
4. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002; 418:6898: 650-654.
5. Tatemoto K, Mutt V. Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides. Nature 1980; 285:5764:417-418.
6. Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 2003; 349:10: 941-948.
7. Grandt D, Schimiczek M, Beglinger C, et al. Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36. Regul Pept 1994; 51:2:151-159.
8. Frayn KN. Metabolic regulation. A human perspective. Blackwel Publisching Company. Oxford. United Kingdom. 2003; 441-446.
9. Helou N, Obeid O, Azar ST, et al. Variation of postprandial PYY 3-36 response following ingestion of differing macronutrient meals in obese females. Ann Nutr Metab 2008; 52(3):188-95.
10. Belyakov, NA, Mazurova VI. Obesity. Guidelines for physicians. St. Petersburg, 2003.
11. Viardot A, Heilbronn LK, Herzog H, et al. Abnormal postprandial PYY response in insulin sensitive nondiabetic subjects with a strong family history of type 2 diabetes. Int J Оbes 2008; 32:6:943-948.
12. Xu J, McNearney TA, Chen J. Impaired postprandial releases/syntheses of ghrelin and PYY (3-36) and blunted responses to exogenous ghrelin and PYY (3-36) in a rodent model of diet-induced obesity. J Gastroenterol Hepatol 2011 Apr; 26(4):700-5.
13. Dalia El, Khoury D, Rola El-Rassi R, Azar S, Hwalla N.  Postprandial grelin and PYY responses of male subjects on low carbohydrate meals to varied balancing proportions of proteins and fats. Eur J Nutr 2010 Dec; 49(8):493-500.
14. Everitt BJ, Hokfelt T, Terenius L, et al. Differential co-existence of neuropeptides Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience 1984; 11:2:443-462.
15. Harfstrand A, Eneroth P, Agnati L, Fuxe K. Further studies on the effects of central administration of neuropeptide Y on neuroendocrine function in the male rat: relationship to hypothalamic catecholamines. Regul Pept 1987; 17:3:167-179.
16. Kubota Y, Inagaki S, Kito S, et al. Neuropeptide Y-immunoreactive neurons receive synaptic inputs from dopaminergic axon terminals in the rat neostriatum. Brain Res 1988; 458:2:389-393.
17. Sahu A, Kalra SP, Crowley WR, Kalra PS. Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior. Brain Res 1988; 457:2:376-378.
18. Boey D, Lin S, Karl T, et al. Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity. Diabetologia 2006; 49:6:1360-1370.

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Int J Biomed. 2012; 2(1):26-30. © 2012 International Medical Research and Development Corporation. All rights reserved.