Nicolay F. Katanov State University of Khakassia Abakan, Russian Federation
*Corresponding author: Elizaveta S. Ageeva, PhD, Head of Fundamental Medicine and Hygiene Department, Federal State Budgetary Educational Institution of Higher Professional Education “Katanov State University of Khakassia”, 178, Pushkin str., Abakan, 655004, Khakassia, Russian Federation. Tel: 7-3902-342720, E-Mail:Ageevaeliz@rambler.ru
The ethnic people of the Republic of Khakassia (the Khakas) with ulcer disease show a significant T-cell activation and humoral immune response when compared with the Europoids. The reasons for such differences could be due to certain ethno -specific allelic variants of the interleukins, which considerably change the degree of cytokine expression. The aim was to study the peculiarities of the association of the interleukin-1 (IL-1) gene polymorphisms and interleukin-1 receptor antagonist (IL-1Ra). Patients with chronic gastritis and ulcer disease were examined using the restriction analysis method. The most wide-spread allelic variants among the Khakas were discovered to be CC IL-1β and R4R4 IL-1Ra. In this study, we suggest the necessity to define the population`s risk and the protective genotypes that promote Helicobacter pylori-associated ulcer disease among the Khakas people.
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