Changes in the Parameters of Systemic Hemodynamics and Perfusion during Laparoscopic Cholecystectomy in Patients with Acute Cholecystitis and Possible Correction Methods

Alexander N. Golomidov, Serhiy H. Hryvenko, Evelina R. Kondratiuk, Yuriy V. Artemov, Alexander V. Kosenko, Idris V. Dzhemilov

International Journal of Biomedicine. 2020;10(2):133-137.
DOI: 10.21103/Article10(2)_OA9
Originally published June 15, 2020.


This article presents a clinical and laboratory assessment of the effectiveness of the author’s method for pharmacological correction of hypoxic changes at acute pneumoperitoneum (PP) in patients with acute calculous cholecystitis (ACC) during laparoscopic cholecystectomy (LCE) (Patent of Ukraine No. 119602). The application of the developed technique allows leveling of ischemic and reperfusion changes that occur during LCE in ACC patients by protectively affecting blood lactate level, statistically significantly reducing it after desufflation. The proposed method reduces the number of cardiovascular complications provoked by ischemic disorders on the background of PP by 3.79 times (P<0.05).

acute calculous cholecystitis • laparoscopic cholecystectomy • systemic hemodynamics perfusion • hypoxia

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Received April 17, 2020.
Accepted May 17, 2020.
©2020 International Medical Research and Development Corporation.