Predictive Markers of Missed Miscarriage

Agamurad A. Orazmuradov, Anastasiya N. Akhmatova, Khalid Haddad, Alexander M. Lopatin, Irina V. Bekbaeva, Gayane A. Arakelyan, Marianna Z. Abitova, Sergey I. Kyrtikov, Nozimabonu M. Zokirova, Aleksey A. Lukaev

International Journal of Biomedicine. 2021;11(1):65-67.
DOI: 10.21103/Article11(1)_ShC
Originally published March 5, 2021


The aim of this study was to find useful the serological markers for missed miscarriage (MM) in order to predict the outcome of pregnancy. The study included 141 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were divided into 3 groups. Group 1 included 68 women with MM; Group 2 included 43 women with spontaneous miscarriage; Group 3 included 30 pregnant women without pathology. Proteomic analysis of the blood serum was performed using liquid chromatography-mass spectrometry. The results of our study show that immunoglobulin kappa variable 3-15 (KV315) can be considered as the most promising serologic marker for MM in early gestation. The potential role of KV315 as the serological marker is very important for predicting the course of pregnancy.

missed miscarriage • serological markers • immunoglobulin kappa variable 3-15
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Received February 14, 2021.
Accepted March 2, 2021.
©2021 International Medical Research and Development Corporation.