Glutathione-Dependent Mechanisms of Antioxidant Defense in Men with Pathozoospermia after COVID-19 Infection

ORIGINAL ARTICLE
Nadezhda A. Kurashova, Bair G. Dashiev, Lyubov I. Kolesnikova

 
International Journal of Biomedicine. 2021;11(4):543-545.
DOI: 10.21103/Article11(4)_OA23
Originally published December 10, 2021

Abstract: 

The article presents results of studying the influence of COVID-19 infections on glutathione metabolism in men with pathozoospermia and COVID-19. In erythrocyte cytolysate, we determined concentration of reduced (GSH) and oxidized (GSSG) glutathione and the GSH/GSSG ratio as the main indication of cell redox-status and an important factor in cell redox-dependent signaling control along with the effect GSH-dependent enzymes. Results of our study allowed us to determine the peculiarity of the influence of COVID-19 infection on thee glutathione metabolic pathway. The understanding of the influence mechanisms of SARS-CoV-2 on metabolic processes in the body of men with pathozoospermia has been expanded. The data obtained give grounds and opportunities for a more reasonable approach to the organization of preventive, curative, and rehabilitative measures for COVID-19 infection.

Keywords: 
infertility • men • COVID-19 • glutathione • oxidative stress
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Received September 22, 2021.
Accepted October 7, 2021.
©2021 International Medical Research and Development Corporation.