Dyslipidemia as Predictor of Missed Miscarriage

ORIGINAL ARTICLE
Agamurad A. Orazmuradov, Sergey G. Morozov, Anastasiya N. Akhmatova, Khalid Haddad, Alexander M. Lopatin, Fatima U. Ramazanova, Irina V. Bekbaeva, Sergey I. Kyrtikov, Zhasmina Z. Suleymanova, Aleksey A. Lukaev

 
International Journal of Biomedicine. 2021;11(4):418-421.
DOI: 10.21103/Article11(4)_OA4
Originally published December 10, 2021

Abstract: 

Background: This study aimed at finding the diagnostic and prognostic possibilities of determining apoC-II, as a serological marker for MM in early gestation.
Methods and Results: The study included 182 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were divided into 3 groups. Group 1 (Gr1) included 90 women with MM; Group 2 (Gr2) included 52 women with spontaneous miscarriage; Group 3 included 40 women without pathology (control group [CG]). Lipid metabolism disorders were diagnosed according to the Russian national recommendations of the VII revision(the Russian Society of Cardiologists [RSC, 2020]), considering the European recommendations (2019). Proteomic analysis of the blood serum was performed using LC-MS. Abnormalities in the lipid profile were more common in patients with MM and spontaneous abortions: 62.2% and 59.7% of cases, respectively, which correlates with the identified marker apoC-II in Gr1 and Gr2.
Conclusion: ApoC-II can be considered as the most promising serologic marker for MM in the early gestation period for women with dyslipidemia.

Keywords: 
missed miscarriage • dyslipidemia, apolipoprotein C-II • serological markers
References: 
  1. Non-developing pregnancy. Chapter 14. In: Radzinsky VE, Orazmuradova AA, editors. Early pregnancy. From pregravid preparation to healthy gestation. Москва : StatusPraesens; 2020:509-537
  2. Orazmuradov AA, Akhmatova AN, Haddad Kh, Lopatin AM, Bekbaeva IV, Arakelyan GA, Abitova MZ, Kyrtikov SI, Zokirova NM, Lukaev AA. Predictive Markers of Missed Miscarriage. International Journal of Biomedicine. 2021;11(1):65-67 doi:10.21103/Article11(1)_ShC
  3. Wolska A, Dunbar RL, Freeman LA, Ueda M, Amar MJ, Sviridov DO, Remaley AT. Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism. Atherosclerosis. 2017 Dec;267:49-60. doi: 10.1016/j.atherosclerosis.2017.10.025.
  4. Chen Q, Chen H, Xi F, Sagnelli M, Zhao B, Chen Y, Yang M, Xu D, Jiang Y, Chen G, Luo Q. Association between maternal blood lipids levels during pregnancy and risk of small-for-gestational-age infants. Sci Rep. 2020 Nov 16;10(1):19865. doi: 10.1038/s41598-020-76845-1. 
  5.  Bartels Ä, Egan N, Broadhurst DI, Khashan AS, Joyce C, Stapleton M, O'Mullane J, O'Donoghue K. Maternal serum cholesterol levels are elevated from the 1st trimester of pregnancy: a cross-sectional study. J Obstet Gynaecol. 2012 Nov;32(8):747-52. doi: 10.3109/01443615.2012.714017. 
  6. Lippi G, Albiero A, Montagnana M, Salvagno GL, Scevarolli S, Franchi M, Guidi GC. Lipid and lipoprotein profile in physiological pregnancy. Clin Lab. 2007;53(3-4):173-7. 
  7. Ghio A, Bertolotto A, Resi V, Volpe L, Di Cianni G. Triglyceride metabolism in pregnancy. Adv Clin Chem. 2011;55:133-53. doi: 10.1016/b978-0-12-387042-1.00007-1. 
  8.  Herrera E, Ortega-Senovilla H. Lipid metabolism during pregnancy and its implications for fetal growth. Curr Pharm Biotechnol. 2014;15(1):24-31. doi: 10.2174/1389201015666140330192345. 
  9. Nasioudis D, Doulaveris G, Kanninen TT. Dyslipidemia in pregnancy and maternal-fetal outcome. Minerva Ginecol. 2019 Apr;71(2):155-162. doi: 10.23736/S0026-4784.18.04330-7.
  10. Catov JM, Bodnar LM, Kip KE, Hubel C, Ness RB, Harger G, Roberts JM. Early pregnancy lipid concentrations and spontaneous preterm birth. Am J Obstet Gynecol. 2007 Dec;197(6):610.e1-7. doi: 10.1016/j.ajog.2007.04.024.
  11. Edison RJ, Berg K, Remaley A, Kelley R, Rotimi C, Stevenson RE, Muenke M. Adverse birth outcome among mothers with low serum cholesterol. Pediatrics. 2007 Oct;120(4):723-33. doi: 10.1542/peds.2006-1939.
  12. Magnussen EB, Vatten LJ, Myklestad K, Salvesen KÅ, Romundstad PR. Cardiovascular risk factors prior to conception and the length of pregnancy: population-based cohort study. Am J Obstet Gynecol. 2011 Jun;204(6):526.e1-8. doi: 10.1016/j.ajog.2011.02.016. 
  13. Ziaei S, Bonab KM, Kazemnejad A. Serum lipid levels at 28-32 weeks gestation and hypertensive disorders. Hypertens Pregnancy. 2006;25(1):3-10. doi: 10.1080/10641950500543756
  14. Magnussen EB, Vatten LJ, Lund-Nilsen TI, Salvesen KA, Davey Smith G, Romundstad PR. Prepregnancy cardiovascular risk factors as predictors of pre-eclampsia: population based cohort study. BMJ. 2007 Nov 10;335(7627):978. doi: 10.1136/bmj.39366.416817.BE. 
  15. Clausen T, Djurovic S, Henriksen T. Dyslipidemia in early second trimester is mainly a feature of women with early onset pre-eclampsia. BJOG. 2001 Oct;108(10):1081-7. doi: 10.1111/j.1471-0528.2001.00247.x. 
  16. Enquobahrie DA, Williams MA, Butler CL, Frederick IO, Miller RS, Luthy DA. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. Am J Hypertens. 2004 Jul;17(7):574-81. doi: 10.1016/j.amjhyper.2004.03.666. 
  17. Di Cianni G, Miccoli R, Volpe L, Lencioni C, Ghio A, Giovannitti MG, Cuccuru I, Pellegrini G, Chatzianagnostou K, Boldrini A, Del Prato S. Maternal triglyceride levels and newborn weight in pregnant women with normal glucose tolerance. Diabet Med. 2005 Jan;22(1):21-5. doi: 10.1111/j.1464-5491.2004.01336.x. 
  18. Kitajima M, Oka S, Yasuhi I, Fukuda M, Rii Y, Ishimaru T. Maternal serum triglyceride at 24--32 weeks' gestation and newborn weight in nondiabetic women with positive diabetic screens. Obstet Gynecol. 2001 May;97(5 Pt 1):776-80. doi: 10.1016/s0029-7844(01)01328-x. 
  19. Kushtagi P, Arvapally S. Maternal mid-pregnancy serum triglyceride levels and neonatal birth weight. Int J Gynaecol Obstet. 2009 Sep;106(3):258-9. doi: 10.1016/j.ijgo.2009.03.004. 
  20. van Eijsden M, Vrijkotte TG, Gemke RJ, van der Wal MF. Cohort profile: the Amsterdam Born Children and their Development (ABCD) study. Int J Epidemiol. 2011 Oct;40(5):1176-86. doi: 10.1093/ije/dyq128. 
  21. Vrijkotte TG, Krukziener N, Hutten BA, Vollebregt KC, van Eijsden M, Twickler MB. Maternal lipid profile during early pregnancy and pregnancy complications and outcomes: the ABCD study. J Clin Endocrinol Metab. 2012 Nov;97(11):3917-25. doi: 10.1210/jc.2012-1295.
  22. Glotov AS, Vashukova ES, Kanaeva MD, Dvoeglazova MO, Danilova MM, Marochkina  EYu, et al. Association study of APOE, LPL and NOS3 polymorphisms with the risk of common cardio pathology in children and pregnant women. ECOLOGICAL GENETICS. 2011;9(4):25-34.
  23. Korkmazer E, Ustunyurt E, Tekin B, Cilingir O. Study on potential role of apolipoprotein E in recurrent pregnancy loss. Exp Ther Med. 2013 May;5(5):1408-1410. doi: 10.3892/etm.2013.997. 
  24. Pulawa LK, Jensen DR, Coates A, Eckel RH. Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle. J Lipid Res. 2007 Jan;48(1):145-51. doi: 10.1194/jlr.M600384-JLR200.
  25. Loskutova IV, Bichevskaya RG. Lipid spectrum of blood in pregnant women with recurrent early miscarriage in chronic liver diseases. Sciences of Europe. 2017;20-1(20).
  26. Havel RJ, Fielding CJ, Olivecrona T, Shore VG, Fielding PE, Egelrud T. Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of triglycerides by lipoproteins lipase from different sources. Biochemistry. 1973 Apr 24;12(9):1828-33. doi: 10.1021/bi00733a026.
  27. Fornengo P, Bruno A, Gambino R, Cassader M, Pagano G. Resistant hypertriglyceridemia in a patient with high plasma levels of apolipoprotein CII. Arterioscler Thromb Vasc Biol. 2000 Oct;20(10):2329-39. doi: 10.1161/01.atv.20.10.2329.

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Received July 16, 2021.
Accepted September 28, 2021.
©2021 International Medical Research and Development Corporation.