Dyslipidemia as Predictor of Missed Miscarriage

Agamurad A. Orazmuradov, Sergey G. Morozov, Anastasiya N. Akhmatova, Khalid Haddad, Alexander M. Lopatin, Fatima U. Ramazanova, Irina V. Bekbaeva, Sergey I. Kyrtikov, Zhasmina Z. Suleymanova, Aleksey A. Lukaev

International Journal of Biomedicine. 2021;11(4):418-421.
DOI: 10.21103/Article11(4)_OA4
Originally published December 10, 2021


Background: This study aimed at finding the diagnostic and prognostic possibilities of determining apoC-II, as a serological marker for MM in early gestation.
Methods and Results: The study included 182 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were divided into 3 groups. Group 1 (Gr1) included 90 women with MM; Group 2 (Gr2) included 52 women with spontaneous miscarriage; Group 3 included 40 women without pathology (control group [CG]). Lipid metabolism disorders were diagnosed according to the Russian national recommendations of the VII revision(the Russian Society of Cardiologists [RSC, 2020]), considering the European recommendations (2019). Proteomic analysis of the blood serum was performed using LC-MS. Abnormalities in the lipid profile were more common in patients with MM and spontaneous abortions: 62.2% and 59.7% of cases, respectively, which correlates with the identified marker apoC-II in Gr1 and Gr2.
Conclusion: ApoC-II can be considered as the most promising serologic marker for MM in the early gestation period for women with dyslipidemia.

missed miscarriage • dyslipidemia, apolipoprotein C-II • serological markers
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Received July 16, 2021.
Accepted September 28, 2021.
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