Leukocyte Shift Index and Subtypes of Acute Otitis Media in Children

Nadezhda E. Kuznetsova, Maria N. Ponomareva, Tatiana B. Kuznetsova

International Journal of Biomedicine. 2022;12(1):63-66.
DOI: 10.21103/Article12(1)_ShC1
Originally published March 10, 2022


The aim of this research was to study the features of clinical and laboratory parameters of acute otitis media (AOM), taking into account the value of the leukocyte shift index (LSI) in pediatric patients with the demonstration of clinical cases.
Methods and Results: This study included 100 children (55 boys and 45 girls) with AOM. The mean age of all patients was 4.32±0.31 years. Group 1 included 50 patients (30 boys and 20 girls) with acute suppurative otitis media (SupAOM) . Group 2 included 50 patients  (25 boys and 25 girls)with acute serous otitis media (SerAOM). As a marker for determining the activity of the inflammatory process and the disorders of the immunological reactivity of the body, we chose LSI, calculated taking into account the parameters of the general blood test.     Our results show the diagnostic significance of LSI in predicting the clinical course of AOM in patients in the age group of 2-16 years. The development of SerAOM is predicted when the LSI is 1.05±0.08; SupAOM - 2.08±0.23
The results obtained can be useful in providing specialized medical care for children of this age group, for optimizing the algorithms for preventive examinations and therapeutic interventions, and for offering the possibility of predicting the severity of the disease and timely treatment of SupAOM requiring a surgical intervention followed by systemic antibiotic therapy in order to prevent otogenic complications and hearing.

acute otitis media • leukocyte shift index • children
  1. Garashchenko TI, Kozlova RS. [Acute otitis media in children. Prejudices of pharmacotherapy[. Detskaya Otorinolaringologiya. 2013;(3):31-36. [Article in Russian].
  2. Yablonsky SV. [Modern approaches to the diagnosis and treatment of middle ear diseases in children]. Rossiyskaya Otorinolaringologiya. 2004;(4):91-99. [Article in Russian].
  3. Yakovlev VN, Kunelskaya NL, Yanyushkina ES. [Exudative otitis media]. Vestnik Otorinolaringologii. 2010;(6):77-80. [Article in Russian].
  4. Kuznetsova NE, Sinyakov AYu, Veshkurtseva IM, Kuznetsova TB. [The nature of intracranial complications in purulent-inflammatory pathology of the ear in children]. Scientific-Practical Conference "Modern aspects of head and neck surgery." 2019:17-18. [Article in Russian].
  5. Kuznetsova NE, Mamedov RR, Shcherbakova AF. Prevalence of otitis media with effusion in children. International Journal of Biomedicine. 2020;10(1):86-88. doi: 10.21103/Article10(1)_ShC1
  6. Ivanov DO, Shabalov NP, Shabalova NN, Kurzina EA, Kostyuchek IN. [Leukocyte indices of cellular reactivity as an indicator of the presence of hypo- and hyperergic variants of neonatal sepsis]. Available from: http://www.medlinks.ru/article.php?sid=22330.[Article in Russian].
  7. Mustafina ZhG, Kramorenko IuS, Kobtseva VIu. [Integral hematological indices in assessing body immunological reactivity in patients with ophthalmic pathology]. Klin Lab Diagn. 1999 May;(5):47-9. [Article in Russian].
  8. Speransky II, Samoilenko GE, Lobacheva MV. [Complete blood count - are all of its possibilities exhausted? Integral indices of intoxication as criteria for assessing the severity of endogenous intoxication, its complications, and the effectiveness of treatment]. Acute and Emergency Conditions in the Practice of a Doctor. 2009.19(6):5. [Article in Russian].

Download Article
Received January 14, 2022.
Accepted February 8, 2022.
©2022 International Medical Research and Development Corporation.