Frequency of the Risk A Allele of rs17713054 Localized in the 3p21.31 COVID-19 Risk Locus in the Yakut Population

ORIGINAL ARTICLE
Nadezhda I. Pavlova, Aleksey A. Bochurov, Vladislav A. Alekseev, Aleksandra T. Diakonova, Vladimir V. Dodokhov, Khariton A. Kurtanov

 
International Journal of Biomedicine. 2022;12(1):155-159.
DOI: 10.21103/Article12(1)_OA19
Originally published March 10, 2022

Abstract: 

Background: Genome-wide association studies identified the region of chromosome 3p21.31 as having the strongest association with the severe COVID-19 and susceptibility to SARS-CoV-2 infection. The aim of our study was to investigate the frequency of the risk A allele of rs17713054 localized in the 3p21.31 COVID-19 risk locus in Yakuts.
Methods and Results: A total of 382 DNA samples from healthy Yakut volunteers (184 men and 198 women; the average age of 41.8±0.05 years) were examined. Our results show that the frequency of the risk A allele of the rs17713054 SNP in the Yakut population occurs at a frequency of 2% and generally corresponds to the frequency of East Asian populations (from 0% to 2%), geographically close to the Yakuts and belonging to the same Mongoloid race.

Keywords: 
SARS-CoV-2 • rs17713054 • epithelial-mesenchymal transition • leucine zipper transcription factor like 1
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Received January 30, 2022.
Accepted March 8, 2022.
©2022 International Medical Research and Development Corporation.