Comparative Overview of Different Radiological Imaging Techniques in the Diagnosis of Pulmonary Embolism

Zuhal Y. Hamd

 
International Journal of Biomedicine. 2023;13(1):20-25.
DOI: 10.21103/Article13(1)_RA3
Originally published March 3, 2023

Abstract: 

Background: Imaging techniques such as chest X-ray (CXR), computed tomography pulmonary angiography (CTPA), ventilation-perfusion (V/Q) scintigraphy, and magnetic resonance imaging (MRI) are some methods used to detect and manage acute pulmonary embolism (PE). The aim of this review was a comparative analysis of the various imaging techniques used to evaluate PE.
Methods and Results: The incidence, distribution, clinical features, classification of PE and clinical assessment of the current methods for diagnosis of PE were discussed. CTPA is the gold standard for fast turnaround and accurate diagnosis. Additional probable reasons for sudden chest pain can also be learned through a CT scan. Lung perfusion anomalies can be identified and measured using dual-energy CT. Chest radiographs are only marginally beneficial, occasionally revealing PE or infarction signs, but are helpful in ruling out other possible causes of chest pain. These patients' ventilation-perfusion mismatches are evident in the V/Q scan, which has many grading schemes with conventional ranges from normal to high. While MRI, which is only available in specialist facilities and calls for higher degrees of competence, also offers accurate diagnosis.
Conclusion: Early diagnosis and treatment of PE is challenging due to asymptomatic conditions or overlapping symptoms. Diagnosis of PE in expectant mothers and those with suspected PE recurrence is typically difficult. Over-diagnosis and overtreatment, particularly regarding sub-segmental PE, and the lowered clinical suspicion threshold remain a major concern in PE diagnosis. The routine use and integration of the above diagnostic techniques need to be encouraged in clinical practice to overcome the diagnostic hurdles. The introduction of new diagnostic techniques or improved risk stratification processes might enhance the management of PE.

Keywords: 
pulmonary embolism • computed tomography • magnetic resonance imaging • computed tomography pulmonary angiography • ventilation-perfusion scan • chest radiographs
References: 
  1. Lavorini F, Di Bello V, De Rimini ML, Lucignani G, Marconi L, Palareti G, Pesavento R, Prisco D, Santini M, Sverzellati N, Palla A, Pistolesi M. Diagnosis and treatment of pulmonary embolism: a multidisciplinary approach. Multidiscip Respir Med. 2013 Dec 19;8(1):75. doi: 10.1186/2049-6958-8-75. 
  2. Tarbox AK, Swaroop M. Pulmonary embolism. Int J Crit Illn Inj Sci. 2013 Jan;3(1):69-72. doi: 10.4103/2229-5151.109427.
  3. Nachman D, Pollack A, Herzog E.  Epidemiology, Pathophysiology and Predisposing Factors of Pulmonary Embolism and Deep Vein Thrombosis. In: Herzog, E. (eds) Pulmonary Embolism. Springer, Cham;  2022. doi: 10.1007/978-3-030-87090-4_2
  4. Anderson DR, Kahn SR, Rodger MA, Kovacs MJ, Morris T, Hirsch A, Lang E, Stiell I, Kovacs G, Dreyer J, Dennie C, Cartier Y, Barnes D, Burton E, Pleasance S, Skedgel C, O'Rouke K, Wells PS. Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trial. JAMA. 2007 Dec 19;298(23):2743-53. doi: 10.1001/jama.298.23.2743.
  5. Carrier M, Le Gal G, Wells PS, Rodger MA. Systematic review: case-fatality rates of recurrent venous thromboembolism and major bleeding events among patients treated for venous thromboembolism. Ann Intern Med. 2010 May 4;152(9):578-89. doi: 10.7326/0003-4819-152-9-201005040-00008.
  6. Okada M, Kunihiro Y, Nakashima Y, Nomura T, Kudomi S, Yonezawa T, Suga K, Matsunaga N. Added value of lung perfused blood volume images using dual-energy CT for assessment of acute pulmonary embolism. Eur J Radiol. 2015 Jan;84(1):172-177. doi: 10.1016/j.ejrad.2014.09.009. 
  7. Raymakers AJ, Mayo J, Marra CA, FitzGerald M. Diagnostic strategies incorporating computed tomography angiography for pulmonary embolism: a systematic review of cost-effectiveness analyses. J Thorac Imaging. 2014 Jul;29(4):209-16. doi: 10.1097/RTI.0b013e3182999e41. 
  8. Beckman MG, Hooper WC, Critchley SE, Ortel TL. Venous thromboembolism: a public health concern. Am J Prev Med. 2010 Apr;38(4 Suppl):S495-501. doi: 10.1016/j.amepre.2009.12.017. 
  9. Goldhaber SZ, Bounameaux H. Pulmonary embolism and deep vein thrombosis. Lancet. 2012 May 12;379(9828):1835-46. doi: 10.1016/S0140-6736(11)61904-1. 
  10. Yang S, Yang Y, Zhai Z, Kuang T, Gong J, Zhang S, Zhu J, Liang L, Shen YH, Wang C. Incidence and risk factors of chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism. J Thorac Dis. 2015 Nov;7(11):1927-38. doi: 10.3978/j.issn.2072-1439.2015.11.43. 
  11. Naess IA, Christiansen SC, Romundstad P, Cannegieter SC, Rosendaal FR, Hammerstrøm J. Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost. 2007 Apr;5(4):692-9. doi: 10.1111/j.1538-7836.2007.02450.x. 
  12. DeMonaco NA, Dang Q, Kapoor WN, Ragni MV. Pulmonary embolism incidence is increasing with use of spiral computed tomography. Am J Med. 2008 Jul;121(7):611-7. doi: 10.1016/j.amjmed.2008.02.035. 
  13. Previtali E, Bucciarelli P, Passamonti SM, Martinelli I. Risk factors for venous and arterial thrombosis. Blood Transfus. 2011 Apr;9(2):120-38. doi: 10.2450/2010.0066-10. 
  14. Zhan ZQ, Wang CQ, Nikus KC, He CR, Wang J, Mao S, Dong XJ. Electrocardiogram patterns during hemodynamic instability in patients with acute pulmonary embolism. Ann Noninvasive Electrocardiol. 2014 Nov;19(6):543-51. doi: 10.1111/anec.12163.
  15. Gruettner J, Walter T, Lang S, Meyer M, Apfaltrer P, Henzler T, Viergutz T. Importance of Wells score and Geneva score for the evaluation of patients suspected of pulmonary embolism. In Vivo. 2015 Mar-Apr;29(2):269-72.
  16. Lobo SA, Fischer S. Cardiac Risk Assessment. 2022 Jul 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 30725831.
  17. van Belle A, Büller HR, Huisman MV, Huisman PM, Kaasjager K, Kamphuisen PW, Kramer MH, Kruip MJ, Kwakkel-van Erp JM, Leebeek FW, Nijkeuter M, Prins MH, Sohne M, Tick LW; Christopher Study Investigators. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA. 2006 Jan 11;295(2):172-9. doi: 10.1001/jama.295.2.172. 
  18. Moore AJE, Wachsmann J, Chamarthy MR, Panjikaran L, Tanabe Y, Rajiah P. Imaging of acute pulmonary embolism: an update. Cardiovasc Diagn Ther. 2018 Jun;8(3):225-243. doi: 10.21037/cdt.2017.12.01.
  19. Mirza H, Hashmi MF. Lung Ventilation Perfusion Scan (VQ Scan). 2022 Oct 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 33232086.
  20. Salaun PY, Couturaud F, Le Duc-Pennec A, Lacut K, Le Roux PY, Guillo P, Pennec PY, Cornily JC, Leroyer C, Le Gal G. Noninvasive diagnosis of pulmonary embolism. Chest. 2011 Jun;139(6):1294-1298. doi: 10.1378/chest.10-1209. 
  21. Lang I. Chronic thromboembolic pulmonary hypertension: a distinct disease entity. Eur Respir Rev. 2015 Jun;24(136):246-52. doi: 10.1183/16000617.00001115.
  22. Wiener RS, Schwartz LM, Woloshin S. Time trends in pulmonary embolism in the United States: evidence of overdiagnosis. Arch Intern Med. 2011 May 9;171(9):831-7. doi: 10.1001/archinternmed.2011.178. 
  23. Le Roux PY, Robin P, Salaun PY. New developments and future challenges of nuclear medicine and molecular imaging for pulmonary embolism. Thromb Res. 2018 Mar;163:236-241. doi: 10.1016/j.thromres.2017.06.031.
  24. Jany B, Welte T. Pleural Effusion in Adults-Etiology, Diagnosis, and Treatment. Dtsch Arztebl Int. 2019 May 24;116(21):377-386. doi: 10.3238/arztebl.2019.0377. 
  25. Moore AJE, Wachsmann J, Chamarthy MR, Panjikaran L, Tanabe Y, Rajiah P. Imaging of acute pulmonary embolism: an update. Cardiovasc Diagn Ther. 2018 Jun;8(3):225-243. doi: 10.21037/cdt.2017.12.01. 
  26. Stein PD, Fowler SE, Goodman LR, Gottschalk A, Hales CA, Hull RD, Leeper KV Jr, Popovich J Jr, Quinn DA, Sos TA, Sostman HD, Tapson VF, Wakefield TW, Weg JG, Woodard PK; PIOPED II Investigators. Multidetector computed tomography for acute pulmonary embolism. N Engl J Med. 2006 Jun 1;354(22):2317-27. doi: 10.1056/NEJMoa052367.
  27. Berdahl CT, Vermeulen MJ, Larson DB, Schull MJ. Emergency department computed tomography utilization in the United States and Canada. Ann Emerg Med. 2013 Nov;62(5):486-494.e3. doi: 10.1016/j.annemergmed.2013.02.018. 
  28. Hassan HGEMA, Khater NH, Elia RZ. Added value of hyperdense lumen sign in prediction of acute central and peripheral pulmonary embolism on non-contrast CT chest. Egypt J Radiol Nucl Med. 2021;52(1):84. doi: 10.1186/s43055-021-00462-9.
  29. Woo JK, Chiu RY, Thakur Y, Mayo JR. Risk-benefit analysis of pulmonary CT angiography in patients with suspected pulmonary embolus. AJR Am J Roentgenol. 2012 Jun;198(6):1332-9. doi: 10.2214/AJR.10.6329. Erratum in: AJR Am J Roentgenol. 2013 Oct;201(4):935. 
  30. Luk L, Steinman J, Newhouse JH. Intravenous Contrast-Induced Nephropathy-The Rise and Fall of a Threatening Idea. Adv Chronic Kidney Dis. 2017 May;24(3):169-175. doi: 10.1053/j.ackd.2017.03.001.
  31. Heller M, Krieger P, Finefrock D, Nguyen T, Akhtar S. Contrast CT Scans in the Emergency Department Do Not Increase Risk of Adverse Renal Outcomes. West J Emerg Med. 2016 Jul;17(4):404-8. doi: 10.5811/westjem.2016.4.28994. 
  32. Beckett KR, Moriarity AK, Langer JM. Safe Use of Contrast Media: What the Radiologist Needs to Know. Radiographics. 2015 Oct;35(6):1738-50. doi: 10.1148/rg.2015150033.
  33. Li X, Chen J, Zhang L, Liu H, Wang S, Chen X, Fang J, Wang S, Zhang W. Clinical observation of the adverse drug reactions caused by non-ionic iodinated contrast media: results from 109,255 cases who underwent enhanced CT examination in Chongqing, China. Br J Radiol. 2015 Mar;88(1047):20140491. doi: 10.1259/bjr.20140491. 
  34. Sohoni CA. Peripheral wedge-shaped radiographic lung opacity in a young patient. Lung India. 2015 Mar-Apr;32(2):184-5. doi: 10.4103/0970-2113.152651.
  35. Nishiyama KH, Saboo SS, Tanabe Y, Jasinowodolinski D, Landay MJ, Kay FU. Chronic pulmonary embolism: diagnosis. Cardiovasc Diagn Ther. 2018 Jun;8(3):253-271. doi: 10.21037/cdt.2018.01.09. 
  36. Moore AJE, Wachsmann J, Chamarthy MR, Panjikaran L, Tanabe Y, Rajiah P. Imaging of acute pulmonary embolism: an update. Cardiovasc Diagn Ther. 2018 Jun;8(3):225-243. doi: 10.21037/cdt.2017.12.01. 
  37. Im DJ, Hur J, Han KH, Lee HJ, Kim YJ, Kwon W, Choi BW. Acute Pulmonary Embolism: Retrospective Cohort Study of the Predictive Value of Perfusion Defect Volume Measured With Dual-Energy CT. AJR Am J Roentgenol. 2017 Nov;209(5):1015-1022. doi: 10.2214/AJR.17.17815. 
  38. Qanadli SD, El Hajjam M, Vieillard-Baron A, Joseph T, Mesurolle B, Oliva VL, Barré O, Bruckert F, Dubourg O, Lacombe P. New CT index to quantify arterial obstruction in pulmonary embolism: comparison with angiographic index and echocardiography. AJR Am J Roentgenol. 2001 Jun;176(6):1415-20. doi: 10.2214/ajr.176.6.1761415. 
  39. Mastora I, Remy-Jardin M, Masson P, Galland E, Delannoy V, Bauchart JJ, Remy J. Severity of acute pulmonary embolism: evaluation of a new spiral CT angiographic score in correlation with echocardiographic data. Eur Radiol. 2003 Jan;13(1):29-35. doi: 10.1007/s00330-002-1515-y. 
  40. Furlan A, Aghayev A, Chang CC, Patil A, Jeon KN, Park B, Fetzer DT, Saul M, Roberts MS, Bae KT. Short-term mortality in acute pulmonary embolism: clot burden and signs of right heart dysfunction at CT pulmonary angiography. Radiology. 2012 Oct;265(1):283-93. doi: 10.1148/radiol.12110802.
  41. Yu T, Yuan M, Zhang Q, Shi H, Wang D. Evaluation of computed tomography obstruction index in guiding therapeutic decisions and monitoring percutanous catheter fragmentation in massive pulmonary embolism. J Biomed Res. 2011 Nov;25(6):431-7. doi: 10.1016/S1674-8301(11)60057-2.
  42. Kubo T, Lin PJ, Stiller W, Takahashi M, Kauczor HU, Ohno Y, Hatabu H. Radiation dose reduction in chest CT: a review. AJR Am J Roentgenol. 2008 Feb;190(2):335-43. doi: 10.2214/AJR.07.2556.
  43. Mayo J, Thakur Y. Pulmonary CT angiography as first-line imaging for PE: image quality and radiation dose considerations. AJR Am J Roentgenol. 2013 Mar;200(3):522-8. doi: 10.2214/AJR.12.9928. 
  44. Ridge CA, Litmanovich D, Bukoye BA, Lin PJ, Wilcox C, Boiselle PM, Bankier AA. Computed tomography angiography for suspected pulmonary embolism: comparison of 2 adaptive statistical iterative reconstruction blends to filtered back-projection alone. J Comput Assist Tomogr. 2013 Sep-Oct;37(5):712-7. doi: 10.1097/RCT.0b013e31829727d2. 
  45. Pontana F, Henry S, Duhamel A, Faivre JB, Tacelli N, Pagniez J, Remy J, Remy-Jardin M. Impact of iterative reconstruction on the diagnosis of acute pulmonary embolism (PE) on reduced-dose chest CT angiograms. Eur Radiol. 2015 Apr;25(4):1182-9. doi: 10.1007/s00330-014-3393-5. 
  46. Bogot NR, Fingerle A, Shaham D, Nissenbaum I, Sosna J. Image quality of low-energy pulmonary CT angiography: comparison with standard CT. AJR Am J Roentgenol. 2011 Aug;197(2):W273-8. doi: 10.2214/AJR.10.5318.
  47. Schueller-Weidekamm C, Schaefer-Prokop CM, Weber M, Herold CJ, Prokop M. CT angiography of pulmonary arteries to detect pulmonary embolism: improvement of vascular enhancement with low kilovoltage settings. Radiology. 2006 Dec;241(3):899-907. doi: 10.1148/radiol.2413040128. 
  48. Petersilka M, Bruder H, Krauss B, Stierstorfer K, Flohr TG. Technical principles of dual source CT. Eur J Radiol. 2008 Dec;68(3):362-8. doi: 10.1016/j.ejrad.2008.08.013.
  49. Kerl JM, Lehnert T, Schell B, Bodelle B, Beeres M, Jacobi V, Vogl TJ, Bauer RW. Intravenous contrast material administration at high-pitch dual-source CT pulmonary angiography: test bolus versus bolus-tracking technique. Eur J Radiol. 2012 Oct;81(10):2887-91. doi: 10.1016/j.ejrad.2011.09.018. 
  50. Bauer RW, Schell B, Beeres M, Wichmann JL, Bodelle B, Vogl TJ, Kerl JM. High-pitch dual-source computed tomography pulmonary angiography in freely breathing patients. J Thorac Imaging. 2012 Nov;27(6):376-81. doi: 10.1097/RTI.0b013e318250067e. 
  51. Hou DJ, Tso DK, Davison C, Inacio J, Louis LJ, Nicolaou S, Reimann AJ. Clinical utility of ultra high pitch dual source thoracic CT imaging of acute pulmonary embolism in the emergency department: are we one step closer towards a non-gated triple rule out? Eur J Radiol. 2013 Oct;82(10):1793-8. doi: 10.1016/j.ejrad.2013.05.003.
  52. Bucher AM, Kerl MJ, Albrecht MH, Beeres M, Ackermann H, Wichmann JL, Vogl TJ, Bauer RW, Lehnert T. Systematic Comparison of Reduced Tube Current Protocols for High-pitch and Standard-pitch Pulmonary CT Angiography in a Large Single-center Population. Acad Radiol. 2016 May;23(5):619-27. doi: 10.1016/j.acra.2016.01.003.
  53. Lu GM, Luo S, Meinel FG, McQuiston AD, Zhou CS, Kong X, Zhao YE, Zheng L, Schoepf UJ, Zhang LJ. High-pitch computed tomography pulmonary angiography with iterative reconstruction at 80 kVp and 20 mL contrast agent volume. Eur Radiol. 2014 Dec;24(12):3260-8. doi: 10.1007/s00330-014-3365-9. 
  54. Martini K, Meier A, Higashigaito K, Saltybaeva N, Alkadhi H, Frauenfelder T. Prospective Randomized Comparison of High-pitch CT at 80 kVp Under Free Breathing with Standard-pitch CT at 100 kVp Under Breath-Hold for Detection of Pulmonary Embolism. Acad Radiol. 2016 Nov;23(11):1335-1341. doi: 10.1016/j.acra.2016.07.010. 
  55. Meinel FG, Canstein C, Schoepf UJ, Sedlmaier M, Schmidt B, Harris BS, Flohr TG, De Cecco CN. Image quality and radiation dose of low tube voltage 3rd generation dual-source coronary CT angiography in obese patients: a phantom study. Eur Radiol. 2014 Jul;24(7):1643-50. doi: 10.1007/s00330-014-3194-x. 
  56. Parker JA, Coleman RE, Grady E, Royal HD, Siegel BA, Stabin MG, Sostman HD, Hilson AJ; Society of Nuclear Medicine. SNM practice guideline for lung scintigraphy 4.0. J Nucl Med Technol. 2012 Mar;40(1):57-65. doi: 10.2967/jnmt.111.101386. 
  57. Roach PJ, Bailey DL, Harris BE. Enhancing lung scintigraphy with single-photon emission computed tomography. Semin Nucl Med. 2008 Nov;38(6):441-9. doi: 10.1053/j.semnuclmed.2008.06.002. 
  58. Dorbala S, Ananthasubramaniam K, Armstrong IS, Chareonthaitawee P, DePuey EG, Einstein AJ, Gropler RJ, Holly TA, Mahmarian JJ, Park MA, Polk DM, Russell R 3rd, Slomka PJ, Thompson RC, Wells RG. Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation. J Nucl Cardiol. 2018 Oct;25(5):1784-1846. doi: 10.1007/s12350-018-1283-y. 
  59. Roach PJ, Schembri GP, Bailey DL. V/Q scanning using SPECT and SPECT/CT. J Nucl Med. 2013 Sep;54(9):1588-96. doi: 10.2967/jnumed.113.124602. 
  60. Leblanc M, Leveillée F, Turcotte E. Prospective evaluation of the negative predictive value of V/Q SPECT using 99mTc-Technegas. Nucl Med Commun. 2007 Aug;28(8):667-72. doi: 10.1097/MNM.0b013e32827a8e99. 
  61. Yandrapalli S, Puckett Y. SPECT Imaging. 2022 Oct 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 33232084.
  62. Bajc M, Neilly JB, Miniati M, Schuemichen C, Meignan M, Jonson B; EANM Committee. EANM guidelines for ventilation/perfusion scintigraphy : Part 1. Pulmonary imaging with ventilation/perfusion single photon emission tomography. Eur J Nucl Med Mol Imaging. 2009 Aug;36(8):1356-70. doi: 10.1007/s00259-009-1170-5.
  63. Hochhegger B, Ley-Zaporozhan J, Marchiori E, Irion K, Souza AS Jr, Moreira J, Kauczor HU, Ley S. Magnetic resonance imaging findings in acute pulmonary embolism. Br J Radiol. 2011 Mar;84(999):282-7. doi: 10.1259/bjr/26121475. 
  64. Oudkerk M, van Beek EJ, Wielopolski P, van Ooijen PM, Brouwers-Kuyper EM, Bongaerts AH, Berghout A. Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study. Lancet. 2002 May 11;359(9318):1643-7. doi: 10.1016/S0140-6736(02)08596-3. 
  65. Stein PD, Chenevert TL, Fowler SE, Goodman LR, Gottschalk A, Hales CA, Hull RD, Jablonski KA, Leeper KV Jr, Naidich DP, Sak DJ, Sostman HD, Tapson VF, Weg JG, Woodard PK; PIOPED III (Prospective Investigation of Pulmonary Embolism Diagnosis III) Investigators. Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III). Ann Intern Med. 2010 Apr 6;152(7):434-43, W142-3. doi: 10.7326/0003-4819-152-7-201004060-00008. 
  66. Kluge A, Luboldt W, Bachmann G. Acute pulmonary embolism to the subsegmental level: diagnostic accuracy of three MRI techniques compared with 16-MDCT. AJR Am J Roentgenol. 2006 Jul;187(1):W7-14. doi: 10.2214/AJR.04.1814.
  67. Pahade JK, Litmanovich D, Pedrosa I, Romero J, Bankier AA, Boiselle PM. Quality initiatives: imaging pregnant patients with suspected pulmonary embolism: what the radiologist needs to know. Radiographics. 2009 May-Jun;29(3):639-54. doi: 10.1148/rg.293085226.

Download Article
Received December 12, 2022.
Accepted February 23, 2023.
©2023 International Medical Research and Development Corporation.