Anaplastic Pleomorphic Xanthoastrocytoma, WHO Grade 3, Located on the Hippocampal Region: A Case Report

Serbeze Kabashi-Muçaj, Agon Mekaj, Mentor Petrela, Besim Latifi, Gentian Kaloshi, Flaka Pasha, Kreshnike Dedushi Hoti, Arben Rroji, Labinot Shahini, Fjolla Hyseni, Sefedin Muçaj

International Journal of Biomedicine. 2023;13(1):172-176.
DOI: 10.21103/Article13(1)_CR2
Originally published March 3, 2023


Anaplastic pleomorphic xanthoastrocytoma (APXA) is a rare and aggressive brain tumor that requires a multidisciplinary approach for proper diagnosis and treatment. This case report presents the case of a 15-year-old male patient diagnosed with APXA in the left temporal region. The patient underwent a combination of imaging studies, including MRI, followed by a biopsy of the tumor tissue and surgery. The patient was then closely monitored for recurrence and progression of the tumor, and further received six cycles of chemotherapy and radiation therapy.
This report aims to provide detailed information about the diagnostic process for APXA, which can be challenging due to its similarity to other tumors, such as pilocytic astrocytoma. Additionally, the report highlights the varying treatment options and outcomes for patients with APXA, as well as the importance of close monitoring for the recurrence and progression of the tumor. More research is needed to fully understand the best treatment options for APXA and to improve outcomes for patients diagnosed with this rare and aggressive brain tumor.

anaplastic pleomorphic xanthoastrocytoma • brain tumor • hippocampus • MRI • biopsy
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Received January 31, 2023.
Accepted March 1, 2023.
©2023 International Medical Research and Development Corporation.