Presentation of Myopericytoma in the Lower Leg: A Case Report with a Brief Review of the Literature

Redon Jashari, Afrim Shabani, Dijon Musliu, Donjet Bislimi, Ardita Kafexholli

International Journal of Biomedicine. 2023;13(2):361-363.
DOI: 10.21103/Article13(2)_CR6
Originally published June 5, 2023


Myopericitoma is a rare benign tumor of soft tissue that emerges from perivascular smooth tissue. Myopericitoma primarily derives from soft tissue and skin of the inferior extremities and is rarely found in internal organs. Considering the rare encounter with this neoplasia, it is often misdiagnosed as lipoma or atheroma. Our patient presents with a lump in the lateral region of the Achilles tendon on the right side. On inspection, a small, painful lump of approximately 5 mm×5 mm is noticed without cutaneous changes. In histopathologic examination, branched blood vessels are detected with a characteristic “hemangiopericytoma look-alike” appearance surrounded by prolonged myoid cells.

myopericitoma • myoid cells • lower extremities

1.Fletcher CDM, Unni KK, Mertens F. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press; 2002.
2.Zhang Z, Yu D, Shi H, Xie D. Renal myopericytoma: A case report with a literature review. Oncol Lett. 2014 Jan;7(1):285-287. doi: 10.3892/ol.2013.1678.
3.Chen Z, Liang W. Myopericytoma occurrence in the liver and stomach space: imaging performance. BMC Cancer. 2017 Feb 20;17(1):143. doi: 10.1186/s12885-017-3146-3.
4. Rousseau A, Kujas M, van Effenterre R, Boch AL, Carpentier A, Leroy JP, Poirier J. Primary intracranial myopericytoma: report of three cases and review of the literature. Neuropathol Appl Neurobiol. 2005 Dec;31(6):641-8. doi: 10.1111/j.1365-2990.2005.00681.x.
5.Laga AC, Tajirian AL, Islam MN, Bhattacharyya I, Cohen DM, Plamondon CJ, Robinson-Bostom L. Myopericytoma: report of two cases associated with trauma. J Cutan Pathol. 2008 Sep;35(9):866-70. doi: 10.1111/j.1600-0560.2007.00910.x.
6.Provenzano D, Lo Bianco S, Belfiore M, Buffone A, Cannizzaro MA. Foot soft tissue myopericytoma: Case-report and review. Int J Surg Case Rep. 2017 Nov 9;41:377-382. doi: 10.1016/j.ijscr.2017.10.061. 
7.Requena L, Kutzner H, Hügel H, Rütten A, Furio V. Cutaneous adult myofibroma: a vascular neoplasm. J Cutan Pathol. 1996 Oct;23(5):445-57. doi: 10.1111/j.1600-0560.1996.tb01434.x.
8.Granter SR, Badizadegan K, Fletcher CD. Myofibromatosis in adults, glomangiopericytoma, and myopericytoma: a spectrum of tumors showing perivascular myoid differentiation. Am J Surg Pathol. 1998 May;22(5):513-25. doi: 10.1097/00000478-199805000-00001. 
9.Hung YP, Fletcher CDM. Myopericytomatosis: Clinicopathologic Analysis of 11 Cases With Molecular Identification of Recurrent PDGFRB Alterations in Myopericytomatosis and Myopericytoma. Am J Surg Pathol. 2017 Aug;41(8):1034-1044. doi: 10.1097/PAS.0000000000000862. 
10.Mentzel T, Dei Tos AP, Sapi Z, Kutzner H. Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol. 2006 Jan;30(1):104-13. doi: 10.1097/01.pas.0000178091.54147.b1.
11.Ide F, Obara K, Yamada H, Mishima K, Saito I. Intravascular myopericytoma of the oral mucosa: a rare histologic variant in an uncommon location. Virchows Arch. 2007 Apr;450(4):475-7. doi: 10.1007/s00428-007-0368-9.
12.Iosue H, Rosenblum B. Myopericytoma of the Foot: A Case Report. J Foot Ankle Surg. 2019 Jul;58(4):811-813. doi: 10.1053/j.jfas.2018.11.026. 
13.Provenzano D, Lo Bianco S, Belfiore M, Buffone A, Cannizzaro MA. Foot soft tissue myopericytoma: Case-report and review. Int J Surg Case Rep. 2017 Nov 9;41:377-382. doi: 10.1016/j.ijscr.2017.10.061.
14.Dray MS, McCarthy SW, Palmer AA, Bonar SF, Stalley PD, Marjoniemi V, Millar E, Scolyer RA. Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases. J Clin Pathol. 2006 Jan;59(1):67-73. doi: 10.1136/jcp.2005.028704.
15.Sapelli S, Ribas M, Martins WD, de Noronha L, Gomes AP. Myopericytoma of the lip: report of case. Head Neck. 2009 Apr;31(4):561-4. doi: 10.1002/hed.20933. 
16.Mahapatra P, Dunne J, Colville RJ. Digital artery intravascular myopericytoma--a rare cause of a painful finger. J Hand Surg Eur Vol. 2015 Sep;40(7):753-4. doi: 10.1177/1753193414534380.

Download Article
Received February 26, 2023.
Accepted March 26, 2023.
©2023 International Medical Research and Development Corporation.