Parapharyngeal Acinic Cell Carcinoma: A Case Report of a Rare Extra-Parotid Occurrence

Rinë Limani, Fahredin Veselaj, Zgjim Limani, Labinota Kondirolli, Brikenë Blakaj Gashi

International Journal of Biomedicine. 2023;13(3):162-164.
DOI: 10.21103/Article13(3)_CR1
Originally published September 5, 2023


Parapharyngeal space (PPS) tumors are among the most challenging tumors of the head and neck region to diagnose and treat. Acinic cell carcinoma (ACC) is an extremely rare extra-parotid malignant neoplasm of the PPS. Herewith, we report a case of extra-parotid, low-grade solid pattern ACC diagnosed in a 55-year-old male who presented with a left parapharyngeal bulge. Despite its rare occurrence, ACC of the PPS should be included in the differential diagnosis of PPS tumors.

pharapharyngeal space • acinic cell carcinoma • extra-parotid
  1. Babu SS, Sunil S, Prathap A, Mathew AL. Acinic cell carcinoma of the posterior buccal mucosa: A rare case report. J Cancer Res Ther. 2020 Apr-Jun;16(3):675-679. doi: 10.4103/jcrt.JCRT_399_18. 
  2. Jiang C, Wang W, Chen S, Liu Y. Management of Parapharyngeal Space Tumors: Clinical Experience with a Large Sample and Review of the Literature. Curr Oncol. 2023 Jan 11;30(1):1020-1031. doi: 10.3390/curroncol30010078. 
  3. Galli J, Rolesi R, Gallus R, Seccia A, Pedicelli A, Bussu F, Scarano E. Parapharyngeal Space Tumors: Our Experience. J Pers Med. 2023 Feb 2;13(2):283. doi: 10.3390/jpm13020283.
  4. Shahab R, Heliwell T, Jones AS. How we do it: a series of 114 primary pharyngeal space neoplasms. Clin Otolaryngol. 2005 Aug;30(4):364-7. doi: 10.1111/j.1365-2273.2005.00993.x. 
  5. Riffat F, Dwivedi RC, Palme C, Fish B, Jani P. A systematic review of 1143 parapharyngeal space tumors reported over 20 years. Oral Oncol. 2014 May;50(5):421-30. doi: 10.1016/j.oraloncology.2014.02.007.
  6. van Hees T, van Weert S, Witte B, René Leemans C. Tumors of the parapharyngeal space: the VU University Medical Center experience over a 20-year period. Eur Arch Otorhinolaryngol. 2018 Apr;275(4):967-972. doi: 10.1007/s00405-018-4891-x. 
  7. Hughes KV 3rd, Olsen KD, McCaffrey TV. Parapharyngeal space neoplasms. Head Neck. 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209.
  8. Chen Z, Chen YL, Yu Q, Zhou SH, Bao YY, Shang DS, Ruan LX. Excision of tumors in the parapharyngeal space using an endoscopically assisted transoral approach: a case series and literature review. J Int Med Res. 2019 Mar;47(3):1103-1113. doi: 10.1177/0300060518816190.
  9. El-Naggar AK, JKC C, Grandis JR, Takata T, Grandis J, Slootweg P (eds). WHO Classification of Head and Neck Tumours, 4th Edition, Volume 9.  Lyon, IARC; 2017.
  10. Yokoyama M, Nomura Y, Semba T. Acinic cell carcinoma of the parapharyngeal space: case report. Head Neck. 1993 Jan-Feb;15(1):67-9. doi: 10.1002/hed.2880150115. 
  11. Nguyen J, Palacios E, Horam E, Neitzschman H. Unusual parapharyngeal acinic cell carcinoma. Ear Nose Throat J. 2012 Jan;91(1):16-20. doi: 10.1177/014556131209100105. Erratum in: Ear Nose Throat J. 2012 Feb;91(2):53.
  12. Lien KH, Young CK, Chin SC, Liao CT, Huang SF. Parapharyngeal space tumors: a serial case study. J Int Med Res. 2019 Aug;47(8):4004-4013. doi: 10.1177/0300060519862659. 
  13. Segovia VPK, Alonzo DM, Ong EAV. Parapharyngeal Acinic Cell Carcinoma: Initially Managed as a Case of Peritonsillar Abscess. Int J Head Neck Surg. 2022;13(3):88–9
  14. Kumral TL, Uyar Y, Yildrim G, Berkiten G, Salturk Z. Parafarengeal Bölgede Ekstra-Parotidea Asinik Hücreli Karsinom. ENTcase. 2016;2(1):28-32
  15. Tumors of the Salivary Glands, Atlas of Tumor Pathology: Third Series. Fascicle 17 G. L. Ellis and P. L. Auclair. Armed Forces Institute of Pathology, Washington D.C. ISBN: 1 881041 26 3 (Printed). 1996.
  16. Kumar U. Acinic Cell Carcinoma Papillary-Cystic Variant: Diagnostic Pitfalls in Fine Needle Aspiration Cytology. J Clin Diagn Res. 2017 May;11(5):ED05-ED06. doi: 10.7860/JCDR/2017/21347.9772. 
  17. Cha W, Kim MS, Ahn JC, Cho SW, Sunwoo W, Song CM, Kwon TK, Sung MW, Kim KH. Clinical analysis of acinic cell carcinoma in parotid gland. Clin Exp Otorhinolaryngol. 2011 Dec;4(4):188-92. doi: 10.3342/ceo.2011.4.4.188.

Download Article
Received April 28, 2023.
Accepted June 12, 2023.
©2023 International Medical Research and Development Corporation.