Relationship of Cytokine Status Parameters with the Lipid Peroxidation-Antioxidant Defense System in Obese Adolescents

ORIGINAL ARTICLE
Marina A. Darenskaya, Lyubov V. Rychkova, Natalya V. Semenova, Zhanna V. Prokhorova, Olga A. Tugarinova, Tatyana A. Mityukova, Anastasia A. Basalai, Olga E. Poluliakh, Lyubov I. Kolesnikova

 
International Journal of Biomedicine. 2023;13(3):79-83.
DOI: 10.21103/Article13(3)_OA4
Originally published September 5, 2023

Abstract: 
  1. Spinelli A, Buoncristiano M, Kovacs VA, Yngve A, Spiroski I, Obreja G, et al. Prevalence of Severe Obesity among Primary School Children in 21 European Countries. Obes Facts. 2019;12(2):244-258. doi: 10.1159/000500436.
  2. Darenskaya MA, Rychkova LV, Balzhirova DB, Semenova NV, Nikitina OA, Lesnaya A, et al. The level of lipid peroxidation products and medium-molecular-weight peptides in adolescents with obesity. International Journal of Biomedicine. 2023;13(2):292-295. doi: 10.21103/Article13(2)_OA17
  3. O'Connor TG, Williams J, Blair C, Gatzke-Kopp LM, Francis L, Willoughby MT. Predictors of Developmental Patterns of Obesity in Young Children. Front Pediatr. 2020 Mar 24;8:109. doi: 10.3389/fped.2020.00109.
  4. Marseglia L, Manti S, D'Angelo G, Nicotera A, Parisi E, Di Rosa G, Gitto E, Arrigo T. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci. 2014 Dec 26;16(1):378-400. doi: 10.3390/ijms16010378.
  5. Rohm TV, Meier DT, Olefsky JM, Donath MY. Inflammation in obesity, diabetes, and related disorders. Immunity. 2022 Jan 11;55(1):31-55. doi: 10.1016/j.immuni.2021.12.013. 
  6. Wu H, Ballantyne CM. Metabolic Inflammation and Insulin Resistance in Obesity. Circ Res. 2020 May 22;126(11):1549-1564. doi: 10.1161/CIRCRESAHA.119.315896. 
  7. Palma G, Sorice GP, Genchi VA, Giordano F, Caccioppoli C, D'Oria R, Marrano N, Biondi G, Giorgino F, Perrini S. Adipose Tissue Inflammation and Pulmonary Dysfunction in Obesity. Int J Mol Sci. 2022 Jul 1;23(13):7349. doi: 10.3390/ijms23137349.
  8. Darenskaya MA, Kolesnikova LI, Rychkova LV, Kravtsova OV, Semenova NV, Kolesnikov SI. Relationship between lipid metabolism state, lipid peroxidation and antioxidant defense system in girls with constitutional obesity. AIMS Molecular Science. 2021;8(2):117-126. doi: 10.3934/molsci.2021009
  9. Darenskaya MA, Gavrilova OA, Rychkova LV, Kravtsova OV, Grebenkina LA, Osipova EV, et al. The assessment of oxidative stress intensity in adolescents with obesity by the integral index. International Journal of Biomedicine. 2018;8(1):37-41. doi: 10.21103/Article8(1)_OA5
  10. Manzoor MF, Arif Z, Kabir A, Mehmood I, Munir D, Razzaq A, Ali A, Goksen G, Coşier V, Ahmad N, Ali M, Rusu A. Oxidative stress and metabolic diseases: Relevance and therapeutic strategies. Front Nutr. 2022 Oct 17;9:994309. doi: 10.3389/fnut.2022.994309.
  11. Raut SK, Khullar M. Oxidative stress in metabolic diseases: current scenario and therapeutic relevance. Mol Cell Biochem. 2023 Jan;478(1):185-196. doi: 10.1007/s11010-022-04496-z.
  12. Darenskaya MA, Rychkova LV, Kolesnikov SI, Semenova NV, Nikitina OA, Brichagina AS, et al. Biochemical Status of Obese Male Adolescents of Different Ethnicity: Discriminant Analysis in the Identification of the Most Informative Indicators. Bull Exp Biol Med. 2022 Aug;173(4):459-463. doi: 10.1007/s10517-022-05579-z. 
  13. Darenskaya MA, Rychkova LV, Kolesnikov SI, Kravtsova OV, Semenova NV, Brichagina AS, Kolesnikova LI. Changes in lipid peroxidation system during standard therapy for exogenous constitutional obesity in adolescents of different sex. Questions of children's nutrition. 2022;20(1):5-11. doi: 10.20953/1727-5784-2022-1-5-11
  14. Zuo L, Prather ER, Stetskiv M, Garrison DE, Meade JR, Peace TI, Zhou T. Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments. Int J Mol Sci. 2019 Sep 10;20(18):4472. doi: 10.3390/ijms20184472. 
  15. Styne DM, Arslanian SA, Connor EL, Farooqi IS, Murad MH, Silverstein JH, Yanovski JA. Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2017 Mar 1;102(3):709-757. doi: 10.1210/jc.2016-2573.
  16. Volchegorskiĭ IA, Nalimov AG, Iarovinskiĭ BG, Lifshits RI. [Comparison of various approaches to the determination of the products of lipid peroxidation in heptane-isopropanol extracts of blood]. Vopr Med Khim. 1989 Jan-Feb;35(1):127-31. [Article in Russian]. 
  17. Gavrilov VB, Gavrilova AR, Mazhul' LM. [Methods of determining lipid peroxidation products in the serum using a thiobarbituric acid test]. Vopr Med Khim. 1987 Jan-Feb;33(1):118-22. [Article in Russian]. 
  18. Klebanov GI, Babenkova IV, Teselkin IuO, Komarov OS, Vladimirov IuA. [Evaluation of the antioxidative activity of blood plasma using yolk lipoproteins]. Lab Delo. 1988;(5):59-62. [Article in Russian]. 
  19. Smith MM, Minson CT. Obesity and adipokines: effects on sympathetic overactivity. J Physiol. 2012 Apr 15;590(8):1787-801. doi: 10.1113/jphysiol.2011.221036.
  20. Bondia-Pons I, Ryan L, Martinez JA. Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem. 2012 Dec;68(4):701-11. doi: 10.1007/s13105-012-0154-2. 
  21. Povarova OV, Gorodetskaya EA, Kalenikova EI, Medvedev OS. [Metabolic markers and oxidative stress in the pathogenesis of obesity in children]. Russian Bulletin of Perinatology and Pediatrics. 2020;65(1):22-29. doi:10.21508/1027-4065-2020-65-1-22-29. [Article in Russian]. 
  22. Kolesnikova LI, Darenskaya MA, Kolesnikov SI. [Free radical oxidation: a pathophysiologist's view]. Bulletin of Siberian Medicine. 2017;16(4):16-29. doi: 10.20538/1682-0363-2017-4-16–29. [Article in Russian]. 
  23. Darenskaya MA, Rychkova LV, Semenova NV, Belkova NL, Kolesnikova LI.
    The role of oxidative stress and changes in the composition of the gut microbiota in the genesis of adolescent obesity. International Journal of Biomedicine. 2022;12(3):344-348. DOI: 10.21103/Article12(3)_RA3
  24. Vona R, Gambardella L, Cittadini C, Straface E, Pietraforte D. Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases. Oxid Med Cell Longev. 2019 May 5;2019:8267234. doi: 10.1155/2019/8267234.
  25. Darenskaya MA, Rychkova LV, Kolesnikov SI, Kravtsova OV, Semenova NV, Brichagina A, et al. Oxidative stress index levels in Asian adolescents with exogenous-constitutional obesity. International Journal of Biomedicine. 2022;12(1):142-146. DOI: 10.21103/Article12(1)_OA16
  26. Rychkova LV, Darenskaya MA, Semenova NV, Kolesnikov SI, Petrova AG, et al. Oxidative stress intensity in children and adolescents with a new coronavirus infection.  International Journal of Biomedicine. 2022;12(2):242-246. DOI: 10.21103/Article12(2)_OA7

Download Article
Received July 23, 2023.
Accepted August 30, 2023.
©2023 International Medical Research and Development Corporation.

Keywords: 
interleukins • adolescents • lipid peroxidation • obesity
References: 
  1. Spinelli A, Buoncristiano M, Kovacs VA, Yngve A, Spiroski I, Obreja G, et al. Prevalence of Severe Obesity among Primary School Children in 21 European Countries. Obes Facts. 2019;12(2):244-258. doi: 10.1159/000500436.
  2. Darenskaya MA, Rychkova LV, Balzhirova DB, Semenova NV, Nikitina OA, Lesnaya A, et al. The level of lipid peroxidation products and medium-molecular-weight peptides in adolescents with obesity. International Journal of Biomedicine. 2023;13(2):292-295. doi: 10.21103/Article13(2)_OA17
  3. O'Connor TG, Williams J, Blair C, Gatzke-Kopp LM, Francis L, Willoughby MT. Predictors of Developmental Patterns of Obesity in Young Children. Front Pediatr. 2020 Mar 24;8:109. doi: 10.3389/fped.2020.00109.
  4. Marseglia L, Manti S, D'Angelo G, Nicotera A, Parisi E, Di Rosa G, Gitto E, Arrigo T. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci. 2014 Dec 26;16(1):378-400. doi: 10.3390/ijms16010378.
  5. Rohm TV, Meier DT, Olefsky JM, Donath MY. Inflammation in obesity, diabetes, and related disorders. Immunity. 2022 Jan 11;55(1):31-55. doi: 10.1016/j.immuni.2021.12.013. 
  6. Wu H, Ballantyne CM. Metabolic Inflammation and Insulin Resistance in Obesity. Circ Res. 2020 May 22;126(11):1549-1564. doi: 10.1161/CIRCRESAHA.119.315896. 
  7. Palma G, Sorice GP, Genchi VA, Giordano F, Caccioppoli C, D'Oria R, Marrano N, Biondi G, Giorgino F, Perrini S. Adipose Tissue Inflammation and Pulmonary Dysfunction in Obesity. Int J Mol Sci. 2022 Jul 1;23(13):7349. doi: 10.3390/ijms23137349.
  8. Darenskaya MA, Kolesnikova LI, Rychkova LV, Kravtsova OV, Semenova NV, Kolesnikov SI. Relationship between lipid metabolism state, lipid peroxidation and antioxidant defense system in girls with constitutional obesity. AIMS Molecular Science. 2021;8(2):117-126. doi: 10.3934/molsci.2021009
  9. Darenskaya MA, Gavrilova OA, Rychkova LV, Kravtsova OV, Grebenkina LA, Osipova EV, et al. The assessment of oxidative stress intensity in adolescents with obesity by the integral index. International Journal of Biomedicine. 2018;8(1):37-41. doi: 10.21103/Article8(1)_OA5
  10. Manzoor MF, Arif Z, Kabir A, Mehmood I, Munir D, Razzaq A, Ali A, Goksen G, Coşier V, Ahmad N, Ali M, Rusu A. Oxidative stress and metabolic diseases: Relevance and therapeutic strategies. Front Nutr. 2022 Oct 17;9:994309. doi: 10.3389/fnut.2022.994309.
  11. Raut SK, Khullar M. Oxidative stress in metabolic diseases: current scenario and therapeutic relevance. Mol Cell Biochem. 2023 Jan;478(1):185-196. doi: 10.1007/s11010-022-04496-z.
  12. Darenskaya MA, Rychkova LV, Kolesnikov SI, Semenova NV, Nikitina OA, Brichagina AS, et al. Biochemical Status of Obese Male Adolescents of Different Ethnicity: Discriminant Analysis in the Identification of the Most Informative Indicators. Bull Exp Biol Med. 2022 Aug;173(4):459-463. doi: 10.1007/s10517-022-05579-z. 
  13. Darenskaya MA, Rychkova LV, Kolesnikov SI, Kravtsova OV, Semenova NV, Brichagina AS, Kolesnikova LI. Changes in lipid peroxidation system during standard therapy for exogenous constitutional obesity in adolescents of different sex. Questions of children's nutrition. 2022;20(1):5-11. doi: 10.20953/1727-5784-2022-1-5-11
  14. Zuo L, Prather ER, Stetskiv M, Garrison DE, Meade JR, Peace TI, Zhou T. Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments. Int J Mol Sci. 2019 Sep 10;20(18):4472. doi: 10.3390/ijms20184472. 
  15. Styne DM, Arslanian SA, Connor EL, Farooqi IS, Murad MH, Silverstein JH, Yanovski JA. Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2017 Mar 1;102(3):709-757. doi: 10.1210/jc.2016-2573.
  16. Volchegorskiĭ IA, Nalimov AG, Iarovinskiĭ BG, Lifshits RI. [Comparison of various approaches to the determination of the products of lipid peroxidation in heptane-isopropanol extracts of blood]. Vopr Med Khim. 1989 Jan-Feb;35(1):127-31. [Article in Russian]. 
  17. Gavrilov VB, Gavrilova AR, Mazhul' LM. [Methods of determining lipid peroxidation products in the serum using a thiobarbituric acid test]. Vopr Med Khim. 1987 Jan-Feb;33(1):118-22. [Article in Russian]. 
  18. Klebanov GI, Babenkova IV, Teselkin IuO, Komarov OS, Vladimirov IuA. [Evaluation of the antioxidative activity of blood plasma using yolk lipoproteins]. Lab Delo. 1988;(5):59-62. [Article in Russian]. 
  19. Smith MM, Minson CT. Obesity and adipokines: effects on sympathetic overactivity. J Physiol. 2012 Apr 15;590(8):1787-801. doi: 10.1113/jphysiol.2011.221036.
  20. Bondia-Pons I, Ryan L, Martinez JA. Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem. 2012 Dec;68(4):701-11. doi: 10.1007/s13105-012-0154-2. 
  21. Povarova OV, Gorodetskaya EA, Kalenikova EI, Medvedev OS. [Metabolic markers and oxidative stress in the pathogenesis of obesity in children]. Russian Bulletin of Perinatology and Pediatrics. 2020;65(1):22-29. doi:10.21508/1027-4065-2020-65-1-22-29. [Article in Russian]. 
  22. Kolesnikova LI, Darenskaya MA, Kolesnikov SI. [Free radical oxidation: a pathophysiologist's view]. Bulletin of Siberian Medicine. 2017;16(4):16-29. doi: 10.20538/1682-0363-2017-4-16–29. [Article in Russian]. 
  23. Darenskaya MA, Rychkova LV, Semenova NV, Belkova NL, Kolesnikova LI.
    The role of oxidative stress and changes in the composition of the gut microbiota in the genesis of adolescent obesity. International Journal of Biomedicine. 2022;12(3):344-348. DOI: 10.21103/Article12(3)_RA3
  24. Vona R, Gambardella L, Cittadini C, Straface E, Pietraforte D. Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases. Oxid Med Cell Longev. 2019 May 5;2019:8267234. doi: 10.1155/2019/8267234.
  25. Darenskaya MA, Rychkova LV, Kolesnikov SI, Kravtsova OV, Semenova NV, Brichagina A, et al. Oxidative stress index levels in Asian adolescents with exogenous-constitutional obesity. International Journal of Biomedicine. 2022;12(1):142-146. DOI: 10.21103/Article12(1)_OA16
  26. Rychkova LV, Darenskaya MA, Semenova NV, Kolesnikov SI, Petrova AG, et al. Oxidative stress intensity in children and adolescents with a new coronavirus infection.  International Journal of Biomedicine. 2022;12(2):242-246. DOI: 10.21103/Article12(2)_OA7

Download Article
Received July 23, 2023.
Accepted August 30, 2023.
©2023 International Medical Research and Development Corporation.