Kidney Injury Incidence in COVID-19 Patients and Evaluation of Several Function Variables

ORIGINAL ARTICLE
Khawlah Abdallah Salman

 
International Journal of Biomedicine. 2023;13(4):296-300.
DOI: 10.21103/Article13(4)_OA10
Originally published December 5, 2023

Abstract: 

Background: The aim of this study was to assess the prevalence of acute kidney injury (AKI) in COVID-19 patients treated at AL-Saddar Teaching Hospital (Najaf, Iraq).
Methods and Results: The study population consisted of 190 patients treated at AL-Saddar Teaching Hospital (Najaf, Iraq) between June 1 and August 20, 2022. Clinical signs, lung abnormalities, and a positive result from real-time PCR for nasopharyngeal swab samples have all been used to identify infection. Clinical and laboratory information on the patients was gathered for the investigation. A comparative analysis was conducted between patients with acute kidney injury (AKI) (n=67) and without AKI (n=123). The patients without acute kidney injury (AKI) frequently left the hospital in better health (80.9%), and they did not require dialysis, compared to 22.4% of those who had AKI. The percentage of patients in each group admitted to the intensive care unit (ICU) significantly differed with respect to KI: 46.3% with AKI and 15.4% without AKI (P<0.0001). Furthermore, patients with AKI had a higher rate of mortality (13.4%) than those without AKI (0.8%) (P=0.0002).
Conclusion: The results indicated that AKI is prevalent in hospitalized COVID-19 patients and is attributed to in-hospital death rates.

Keywords: 
COVID-19 • kidney injury • intensive care unit
References: 
  1. Klein FR, Renedo MF, Vigliano CA. Evidence of Continued CD4+ and CD8+ T Cell Activity After SARS-COV-2 Clearance in a Late COVID-19 Pneumonia Heart Transplant Patient. Cureus. 2022 May 9;14(5):e24852. doi: 10.7759/cureus.24852.
  2. Samtani R, Krishna K. ACE2 and COVID-19: An anthropological perspective. Anthropol Anz. 2021 Nov 18;78(4):253-256. doi: 10.1127/anthranz/2021/1327. 
  3. Santarpia, G. (2020). Potential Role of ACE2 Inhibition in COVID-19 Severity. American Journal of Biomedical Science & Research. 2020;9(1):76-77. doi: 10.34297/ajbsr.2020.09.001356.
  4. Wong CM, Ching CH, Yeo GP, Asmee MF, Tham ZD, Chen KK, et al. POS-882 INCIDENCE OF PROTEINURIA AND MICROSCOPIC HEMATURIA IN HOSPITALIZED COVID-19 INFECTED PATIENTS- A SINGLE CENTER EXPERIENCE. Kidney International Reports. 2022;7(2):S381-S382. doi: 10.1016/j.ekir.2022.01.920.
  5. Zhang H, Wu T. CD4+T, CD8+T counts and severe COVID-19: A meta-analysis. J Infect. 2020 Sep;81(3):e82-e84. doi: 10.1016/j.jinf.2020.06.036.
  6. Kirilenko N, Ilyina N. COVID-19 and cardiovascular disease: cardiovascular comorbidity, incidence of COVID-19, severity and post-COVID syndrome. Profilakticheskaya Meditsina. 2022;25(5):79-85. doi: 10.17116/profmed20222505179.[ Article in Russian].
  7. Fara A, Mitrev Z, Rosalia RA, Assas BM. Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines. Open Biol. 2020 Sep;10(9):200160. doi: 10.1098/rsob.200160.
  8. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, Wu Y, Zhang L, Yu Z, Fang M, Yu T, Wang Y, Pan S, Zou X, Yuan S, Shang Y. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020 May;8(5):475-481. doi: 10.1016/S2213-2600(20)30079-5. Epub 2020 Feb 24. Erratum in: Lancet Respir Med. 2020 Apr;8(4):e26. 
  9. Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, Li J, Yao Y, Ge S, Xu G. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020 May;97(5):829-838. doi: 10.1016/j.kint.2020.03.005. 
  10. Henry BM, Lippi G. Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection. Int Urol Nephrol. 2020 Jun;52(6):1193-1194. doi: 10.1007/s11255-020-02451-9. 
  11. Oussalah A, Gleye S, Urmes IC, Laugel E, Barbé F, Orlowski S, et al. Follow-Up of Multi-Organ Dysfunction and Inflammation Using Biomarker Kinetics in Patients with Severe COVID-19 Disease and Association with Disease Outcomes: Results from a Referral Center Cohort in the North East of France (4/29/2020). Available at SSRN: https://ssrn.com/abstract=3590489
  12. Borba MGS, Val FFA, Sampaio VS, Alexandre MAA, Melo GC, Brito M, Mourão MPG, Brito-Sousa JD, Baía-da-Silva D, Guerra MVF, Hajjar LA, Pinto RC, Balieiro AAS, Pacheco AGF, Santos JDO Jr, Naveca FG, Xavier MS, Siqueira AM, Schwarzbold A, Croda J, Nogueira ML, Romero GAS, Bassat Q, Fontes CJ, Albuquerque BC, Daniel-Ribeiro CT, Monteiro WM, Lacerda MVG; CloroCovid-19 Team. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial. JAMA Netw Open. 2020 Apr 24;3(4):e208857. doi: 10.1001/jamanetworkopen.2020.8857.
  13. Oksanen A, Kaakinen M, Latikka R, Savolainen I, Savela N, Koivula A. Regulation and Trust: 3-Month Follow-up Study on COVID-19 Mortality in 25 European Countries. JMIR Public Health Surveill. 2020 Apr 24;6(2):e19218. doi: 10.2196/19218. 
  14. Sardu C, Gambardella J, Morelli MB, Wang X, Marfella R, Santulli G. Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence. J Clin Med. 2020 May 11;9(5):1417. doi: 10.3390/jcm9051417. 
  15. Zhang J, Li J, Su L, Yang J, Jiang X, Jiang N, Lei Y, He L, Lu Q, Shen S, Chen F, Peng Z. [Clinical characteristics and risk factors of acute kidney injury in coronavirus disease 2019]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2020 Apr;32(4):407-411. doi: 10.3760/cma.j.cn121430-20200302-00198. [Article in Chinese].
  16. El-Sayed EE, Allayeh AK, Salem AA, Omar SM, Zaghlol SM, Abd-Elmaguid HM, Abdul-Ghaffar MM, ElSharkawy MM. Incidence of acute kidney injury among COVID-19 patients in Egypt. Ren Replace Ther. 2021;7(1):32. doi: 10.1186/s41100-021-00356-6. 
  17. Zheng X, Yang H, Li X, Li H, Xu L, Yu Q, Dong Y, Zhao Y, Wang J, Hou W, Zhang X, Li Y, Hu F, Gao H, Lv J, Yang L. Prevalence of Kidney Injury and Associations with Critical Illness and Death in Patients with COVID-19. Clin J Am Soc Nephrol. 2020 Nov 6;15(11):1549-1556. doi: 10.2215/CJN.04780420.
  18. Hamza A, Shah NN, Azad AM, Ghanshyam OS, Khan Z. Impact of age, gender and comorbidities affecting the severity of COVID-19 infection in Kashmir. J Family Med Prim Care. 2022 Apr;11(4):1519-1524. doi: 10.4103/jfmpc.jfmpc_278_21. 

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Received August 18, 2023.
Accepted September 20, 2023.
©2023 International Medical Research and Development Corporation.