Sirenomelia (Mermaid Syndrome): A Case Report

Mohammed A. Al-Fakih, Zuhal Y. Hamd, Nagwan Elhussein, Sawsan M. A. Nassr, Saba'a A. Ame, Afrah A. Almortadha, Kholoud I. AlArassi, Amal I. Alorainy, Sahar A. Mustafa, Basim Abdullah Alhomida

International Journal of Biomedicine. 2023;13(4):377-379.
DOI: 10.21103/Article13(4)_CR4
Originally published December 5, 2023


This report details the case of a neonate born at 39 weeks of gestation with dysmorphic features (Sirenomelia). After three hours of admission, the patient suffered from a cardiac arrest. Cardiopulmonary resuscitation was performed for 20 minutes, but there was no response, and the neonate died. Sirenomelia is an unusual and fatal congenital deformity, the most severe condition of caudal regression syndrome. This syndrome can cause pelvic-sacral dysplasia, genital anomalies, bilateral pelvic renal fusion with renal dysplasia, colon atresia, unilateral umbilical artery, and imperforated anus.

sirenomelia • mermaid syndrome • neonate • X-ray
  1. Valenzano M, Paoletti R, Rossi A, Farinini D, Garlaschi G, Fulcheri E. Sirenomelia. Pathological features, antenatal ultrasonographic clues, and a review of current embryogenic theories. Hum Reprod Update. 1999 Jan-Feb;5(1):82-6. doi: 10.1093/humupd/5.1.82.
  2. Van Keirsbilck J, Cannie M, Robrechts C, de Ravel T, Dymarkowski S, Van den Bosch T, Van Schoubroeck D. First trimester diagnosis of sirenomelia. Prenat Diagn. 2006 Aug;26(8):684-8. doi: 10.1002/pd.1479. 
  3. Reddy KR, Srinivas S, Kumar S, Reddy S, Prasad H, Irfan GM. Sirenomelia: a rare presentation. J Neonatal Surg. 2012 Jan 1;1(1):7. 
  4. Stein RA. Smith's recognizable patterns of human malformation, 6th edition. Arch Dis Child. 2007 Jun;92(6):562
  5. Stevenson RE, Jones KL, Phelan MC, Jones MC, Barr M Jr, Clericuzio C, Harley RA, Benirschke K. Vascular steal: the pathogenetic mechanism producing sirenomelia and associated defects of the viscera and soft tissues. Pediatrics. 1986 Sep;78(3):451-7. 
  6. Orioli IM, Amar E, Arteaga-Vazquez J, Bakker MK, Bianca S, Botto LD, Clementi M, Correa A, Csaky-Szunyogh M, Leoncini E, Li Z, López-Camelo JS, Lowry RB, Marengo L, Martínez-Frías ML, Mastroiacovo P, Morgan M, Pierini A, Ritvanen A, Scarano G, Szabova E, Castilla EE. Sirenomelia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research, and literature review. Am J Med Genet C Semin Med Genet. 2011 Nov 15;157C(4):358-73. doi: 10.1002/ajmg.c.30324.
  7. Kostov S, Slavchev S, Dzhenkov D, Strashilov S, Yordanov A. Discordance for Potter's Syndrome in a Dichorionic Diamniotic Twin Pregnancy-An Unusual Case Report. Medicina (Kaunas). 2020 Mar 4;56(3):109. doi: 10.3390/medicina56030109. 
  8. Duesterhoeft SM, Ernst LM, Siebert JR, Kapur RP. Five cases of caudal regression with an aberrant abdominal umbilical artery: Further support for a caudal regression-sirenomelia spectrum. Am J Med Genet A. 2007 Dec 15;143A(24):3175-84. doi: 10.1002/ajmg.a.32028.
  9. World Health Organization. Congenital anomalies [Internet]. Geneva: WHO; 2020.
  10. Serudji J. Sirenomelia: A Case Report. Journal of Midwifery. 2022 Jul 30;7(1):45-50. doi:10.25077/jom.7.1.45-50.2022
  11. Torabizadeh Z, Naghshvar F, Nosrati A, Emadian O. Mermaid syndrome, Sirenomelia: A case report and review of literature. Journal of Pediatrics Review. 2013 Jan 10;1(1):56-61.
  12. Xu T, Wang X, Luo H, Yu H. Sirenomelia in twin pregnancy: A case report and literature review. Medicine (Baltimore). 2018 Dec;97(51):e13672. doi: 10.1097/MD.0000000000013672. 

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Received August 14, 2023.
Accepted November 19, 2023.
©2023 International Medical Research and Development Corporation.