Botulinum Neurotoxin BoNT-A in the Management of Hypertrophic Scars and Keloids: A Comprehensive Review

Ramadan S. Hussein

For citation: Hussein RS. Botulinum Neurotoxin BoNT-A in the Management of Hypertrophic Scars and Keloids: A Comprehensive Review. International Journal of Biomedicine. 2024;14(1):15-19. doi:10.21103/Article14(1)_RA2
Originally published March 1, 2024


Hypertrophic scars (HS) and keloids are challenging dermatological conditions that often lead to physical and psychological distress in affected individuals. Current therapeutic approaches have limitations, prompting the exploration of novel treatments. Botulinum Neurotoxin BoNT-A has emerged as a promising candidate in managing these scars. This comprehensive review delves into the pathophysiology of HS and keloids, the shortcomings of existing treatments, and the mechanisms underlying BoNT-A's potential efficacy. Through an analysis of clinical studies and evidence, the review evaluates BoNT-A's impact on scar formation and patient outcomes. Safety and side effects and the potential influence of BoNT-A on quality of life are also considered. Comparative analysis with traditional therapies underscores the advantages and challenges of BoNT-A use. The review concludes by suggesting future research directions and emphasizing the significance of Botulinum Neurotoxin BoNT-A as a promising therapeutic option. This article provides valuable insights for clinicians, researchers, and patients seeking innovative solutions for HS and keloids.

hypertrophic scars • keloids • botulinum neurotoxin
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Received November 6, 2023.
Accepted December 20, 2023.
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