Comparison of Chromatographic Methods for Determination of the Major Metabolites of Catecholamines and Serotonin

Ilgar S. Mamedov¹, PhD; Irina V. Zolkina²*, PhD; Pavel B. Glagovsky¹; Vladimir S. Sukhorukov¹, PhD, ScD

¹Russian State Medical University, Moscow, Russia; ² Research Clinical Institute of Pediatrics, Moscow, Russia

*Corresponding author: Irina V. Zolkina²*, PhD. Research Clinical Institute of Pediatrics, Moscow, Russia E-mail:

Published: June 25, 2015. DOI: 10.21103/Article5(2)_CR8


In the present review, we set out a new high-tech method for determining the major metabolites of catecholamines and serotonin in urine. We then discuss the effects of these substances and the value of their main metabolites in normal and various pathological conditions, and show the efficiency of applying this technique in the laboratory diagnosis of several diseases.

catecholamines; serotonin; homovanillic acid; vanillylmandelic acid; 5-hydroxyindolacetic acid; GC-MS.
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Int J Biomed. 2015; 5(2):87-90. © 2015 International Medical Research and Development Corporation. All rights reserved.