A Quantitative Assessment of the Morphofunctional Activity of the Population of Mast Cells Exposed to Biotechnological Strains of Microorganisms

ORIGINAL ARTICLE
Natalia I. Sheina, Elena V. Budanova, Lyubov I. Mjalina, Yury P. Pivovarov, Viktor V. Korolik, Lyubov P. Sazonova, Valentina V. Kolesnikova

 
International Journal of Biomedicine. 2018;8(2):150-154.   
DOI: 10.21103/Article8(2)_OA9
Originally published June 15, 2018  

Abstract: 

In order to assess the sensitizing properties of bacteria, micromycetes and actinomycetes, the morphofunctional activity of the population of mast cells was tested in rats exposed to biotechnological microorganisms. The result showed the high informative value of the test of peritoneal must cell degranulation. Both the result and the intensity of the response of mast cells to the exposure to the tested strains depend on the taxonomy of microorganisms, their concentration and the mode of inoculation. The test of peritoneal must cell degranulation can be recommended for assessing the biological safety of industrial microorganisms.

Keywords: 
biotechnology • biotechnological microorganisms • industrial microorganisms • mast cells • biosafety standards
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Received March 18, 2018.
Accepted April 2, 2018.
©2018 International Medical Research and Development Corporation.