Synchronous Multiple Primary Lung Cancer: A Case Report

Alexei L. Charyshkin, Evgeniy A. Toneev, Alexander A. Martynov, Ruslan I. Lisyutin, Airat Sh. Zul’karnyaev

International Journal of Biomedicine. 2018;8(2):162-164.   
DOI: 10.21103/Article8(2)_CR1
Originally published June 15, 2018  


The incidence of multiple primary malignancies has increased dramatically in recent decades. Herein we report synchronous multiple primary lung cancer (SMPLC) in a 52-year-old male patient. It is advisable to consider SMPLC as a local pathology and to perform radical surgical treatment, which contributes to a favorable outcome.

synchronous multiple primary lung cancer • multiple primary malignancies • pneumonectomy • lymph node
  1. Warren S, Gate O. Multiple primary malignant tumors. A survey of the literature and statistical study. Am J Cancer. 1932;16:1358–1414.
  2. Grundmann RT, Meyer F. [Second primary malignancy among cancer survivors - epidemiology, prognosis and clinical relevance].  Zentralbl Chir. 2012;137(6):565-74. doi: 10.1055/s-0031-1283939. [Article in German]. PubMed
  3. Feng FY, Zhang DC, Liu XY, Wang YG, Mao YS. [Surgical treatment and prognosis of synchronous double primary lung cancer: a report of 31 cases]. Ai Zheng. 2005;24(2):215-8. [Article in Chinese]. PubMed
  4. Pommier RF, Vetto JT, Lee JT, Johnston KM. Synchronous non-small cell lung cancers. Am J Surg. 1996;171(5):521-4. PubMed
  5. Li F, Zhong WZ, Niu FY, Zhao N, Yang JJ, Yan HH, Wu YL. Multiple primary malignancies involving lung cancer. BMC Cancer. 2015;15:696. doi: 10.1186/s12885-015-1733-8. PubMed
  6.  Kaprin AD, Starinsky VV, Petrova G.V. Status of oncological care for the population of Russia in 2016. М.:MNIOI named after P.A. Herzen; 2017. [In Russian].
  7.  Ferguson MK, DeMeester TR, DesLauriers J, Little AG, Piraux M, Golomb H. Diagnosis and management of synchronous lung cancers. J Thorac Cardiovasc Surg. 1985;89(3):378–85. PubMed
  8. Verhagen AF, van de Wal HJ, Cox AL, Lacquet LK. Surgical treatment of multiple primary lung cancers. Thorac Cardiovasc Surg. 1989;37(2):107–11. PubMed
  9.  Lam S, MacAulay C, Palcic B. Detection and localization of early lung cancer by imaging techniques. Chest. 1993;103(1 Suppl):12S–14S. PubMed
  10. Woolner LB, Fontana RS, Cortese DA, Sanderson DR, Bernatz PE, Payne WS, et al. Roentgenographically occult lung cancer: pathologic findings and frequency of multicentricity during a 10-year period. Mayo Clin Proc. 1984;59(7):453–66. PubMed
  11. van Rens MT, Zanen P, Brutel de La Rivière A, Elbers HR, van Swieten HA, van Den Bosch JM. Survival in synchronous vs. single lung cancer: upstaging better reflects prognosis. Chest. 2000;118(4):952–8. PubMed
  12. Finley DJ, Yoshizawa A, Travis W, Zhou Q, Seshan VE, Bains MS, et al. Predictors of outcomes after surgical treatment of synchronous primary lung cancers. J Thorac Oncol. 2010;5(2):197-205. doi: 10.1097/JTO.0b013e3181c814c5. PubMed
  13. Powell S, Tarchand G, Rector T, Klein M. Synchronous and metachronous malignancies: analysis of the Minneapolis Veterans Affairs (VA) tumor registry. Cancer Causes Control. 2013;24(8):1565-73. doi: 10.1007/s10552-013-0233-x. PubMed
  14. Shen C, Wang X, Tian L, Zhou Y, Chen D, Du H, et al. "Different trend" in multiple primary lung cancer and intrapulmonary metastasis. Eur J Med Res. 2015;20:17. doi: 10.1186/s40001-015-0109-5. PubMed

Download Article
Received March 13, 2018.
Accepted March 21, 2018.
©2018 International Medical Research and Development Corporation.