Markers of Oxidative Stress in Patients with Coronary Heart Disease

Julia A. Kotova, Anna A. Zuikova, Alexander N. Pashkov, Natalia V. Strahova, Olga N. Krasnorutskaya

International Journal of Biomedicine. 2018;8(2):115-117.   
DOI: 10.21103/Article8(2)_OA1
Originally published June 15, 2018  


The aim of this research was to study the blood levels of protein oxidation products and superoxide dismutase (SOD) activity and their relationship with lipid profile parameters in patients with coronary heart disease (CHD). In CHD patients, against a background of low SOD activity, the protein carbonyl content (PCC) level was significantly higher than in the control group. In addition, significant correlations were found between the indices of PCC, SOD activity, and lipid profile parameters. The determination of PCC parameters can serve as a good indicator of the severity of atherosclerosis.

oxidative modification of proteins • superoxide dismutase • oxidative stress • coronary heart disease
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Received April 3, 2018.
Accepted April 12, 2018.
©2018 International Medical Research and Development Corporation.