The Importance of Clinical and Biochemical Markers in the Diagnosis of Disorders of the Psychomotor and Physical Development of Children who Underwent Perinatal CNS Lesions

Olga N. Krasnorutskaya, Vera S. Ledneva, Daniil Yu. Bugrimov, Elena A. Balakireva, Anna A. Zuikova, Julia A. Kotova, Natalia V. Strahova

International Journal of Biomedicine. 2018;8(2):129-133.
DOI: 10.21103/Article8(2)_OA4
Originally published June 15, 2018


The purpose of this study was to evaluate the blood level of neurotrophic factors (S100 protein, nerve growth factor, L- homocysteine ​​and angiotensin II) in the diagnosis of disorders of the psychomotor and physical development of children who underwent perinatal CNS lesions. A comprehensive approach to assessing the blood levels ​​of neurotrophic factors, along with methods of neuroimaging in children in the first 6 months of the postnatal period, allows identification of the total result of multidirectional degenerative-reparative processes in the neurovascular components of CNS and construction of the diagnostically significant criteria of the severity of neuropathology, which determines the physical development of children in the first year of life.

central nervous system • perinatal lesions • biochemical markers • neurotrophic factors
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Received April 3, 2017.
Accepted May 14, 2018.
©2018 International Medical Research and Development Corporation.