Tashkent Medical Academy; Tashkent, Uzbekistan
Currently, there are three general classes of drugs commonly used in the treatment of rheumatoid arthritis: non-steroidal anti-inflammatory agents (NSAIDs), corticosteroids, and disease modifying anti-rheumatic drugs (DMARDs): methotrexate, sulfasalazine, leflunomide, and hydroxychloroquine, as well as biologic DMARDs (biologic agents - genetically engineered drugs): etanercept, infliximab, adalimumab, rituximab, certolizumab, anakinra, and other. Other immunomodulators are occasionally used including azathioprine and cyclosporine. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. However, the high cost of modern technologies indicates a need to study the economic burden of rheumatoid arthritis for a rational choice of a particular method of treatment.
- Rheumatology. Clinical guidelines. Edited by E.L. Nasonov. M.:"GEOTAR-Media"; 2010. [Manual in Russian]
- Hakinaev GA, Sokolov IO, Lysenko IE, Nahratskaya OI. Response to the basic anti-inflammatory therapy in juvenile rheumatoid arthritis and the differentiated approach to the drug choice (three-year follow-up). Lech Vrach 2011; 7:79-82. [Article in Russian].
- Mavlyanov IR, Bekenova GT. Modern approaches to the treatment of rheumatoid arthritis. Med J Uzb 2013; 5:75-84. [Article in Russian].
- Burton W, Morrison A, Maclean R, Ruderman E. Systematic review of studies of productivity loss due to rheumatoid arthritis. Occup Med (Lond) 2006; 56(1):18-27.
- Pincus T, Callahan L. What is the natural history of rheumatoid arthritis? Rheum Dis Clin North Am 1993; 19(1):123-51.
- Voronenkova EA, Lishuta AS, Morozova TE. Pharmacoeconomic aspects of TNF-inhibitors administration in rheumatoid arthritis. Clin Pharm Ther 2008; 17(4):77-82. [Article in Russian].
- Nasonov EL, Baranov AA, Erdes ShF, Alekseeva EI, Il'in A.G, Folomeeva OM. The state of specialized rheumatologic care to adults and children in the Russian Federation. The draft of the Federal Target Program “Rheumatic diseases 2008-2012. Nauchno-prakticheskaya revmatologiya 2007; 2:4-7. [in Russian].
- Maetzel A, Li LC, Pencharz J, Tomlinson G, Bombardier C; Community Hypertension and Arthritis Project Study Team. The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study. Ann Rheum Dis 2004; 63(4):395-401.
- Huscher D, Merkesdal S, Thiele K, Zeidler H, Schneider M, Zink A; German Collaborative Arthritis Centers. Cost of illness in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and systemic lupus erythematosus in Germany. Ann Rheum Dis 2006; 65(9):1175-83.
- Verstappen S, Boonen A, Verkleij H, Bijlsma JW, Buskens E, Jacobs JW; Utrecht Rheumatoid Arthritis Cohort Study Group. Productivity costs among patients with rheumatoid arthritis: the influence of methods and sources to value loss of productivity. Ann Rheum Dis, 2005; 64(12):1754-60.
- Ruof J, Holsemann J, Mittendorf T. Handelmann S, von der Schulenburg JM, Zeidler H, Merkesdal S. Costs of rheumatoid arthritis in Germany: a micro-costing approach based on healthcare payer's data sources. Ann Rheum Dis 2003; 62:544-9.
- Holsemann J, Mittendorf Т, Merkesdal S, Handelmann S, von der Schulenburg JM, Zeidler H, et al. Direct costs related to rheumatoid arthritis: the patient perspective. Ann Rheum Dis 2005; 64:1456-61.
- Fautrel В, Clarke AE, Guillemin F, Adam V, St-Pierre Y, Panaritis T, et al. Costs of rheumatoid arthritis: new estimates from the human capital method and comparison to the willingness-to-pay method. Med Decision Making 2007; 27(2):138-50.
- Verstappen SM, Jacobs JW, Кruize AA. Ehrlich JC, van Albada-Kuipers GA, Verkleij H, et al. Trends in economic consequences of rheumatoid arthritis over two subsequent years. Rheumatology (Oxford) 2007; 46(6):968-74.
- Moiseev SV. Basic therapy of rheumatoid arthritis - what to choose? Clinical Pharm Ther 2012; 21(1):93-7.
- O'Dell J. R. Methotrexate use in rheumatoid arthritis. Rheum Dis Clin North Am 1997; 23(4):779-96.
- Кobelt G, Lindgren P, Singh A, Klareskog L. Cost effectiveness of etanercept (Enbrel) in combination with methotrexate in the treatment of active rheumatoid arthritis based on the TEMPO trial. Ann Rheum Dis 2005; 64(8):1174-9.
- Suarez-Almazor ME, Berrios-Rivera JR, Cox V, Janssen NM, Marcus DM, Sessoms S. Initiation of disease-modifying antirheumatic drug therapy in minority and disadvantaged patients with rheumatoid arthritis. J Rheumatol 2007; 34(12):2400-2407.
- Arjunji R, Dabbous O, Rahman M. A cost efficacy analysis of anti-TNF-alpha therapy in early rheumatoid arthritis using one year radiographic outcomes. Ann Rheum Dis 2006; 65 (Suppl. 2): 274.
- Gao X, Sato R, Nab H, Singh A. Cost-effectiveness of TNF-alpha inhibitors in treatment of rheumatoid arthritis using radiographic progression as the effectiveness measure in the Netherlands. Ann Rheum Dis 2006; 65 (Suppl. 2): 279.
- 21. Bansback NJ, Brennan A, Ghatnekar O. Cost effectiveness of adalimumab in treatment of patients with moderate to severe rheumatoid arthritis in Sweden. Ann Rheum Dis 2005; 64(7):995-1002;
- Merkesdal S, Mittendorf Т, Rihl M, Kirchhoff T, Zeidler H, Schmidt RE. Cost-of-illness in rheumatoid arthritis: the pre- and post-era of TNF-blocker introduction in Germany. Ann Rheum Dis 2007; 66 (Suppl. 2):268.
- Lee K, Chan K, Chan K, Poon P, Lau C. The direct and indirect health care costs and their relationship with HAQ and SF-12 in a cohort of 422 rheumatoid arthritis patients. Ann Rheum Dis 2007; 66 (Suppl. 2):265.
- Engel-Nitz N, Huang X, Globe D, Baumgartner S. Dosing patterns and costs of adalimumab, etanercept, and infliximab among patients with rheumatoid arthritis. Ann. Rheum Dis 2007; 66(Suppl. 2):260.
- Maravic M, Daur_SJ, Sany J. Hospital costs of rheumatoid arthritis in France in 2001. Ann Rheum Dis 2005; 64(Suppl. 3):1318.
- Van den Hout W, Goekoop-Ruiterman YPM, Allaart CF. Cost-utility analysis of four treatment strategies for early rheumatoid arthritis: two year results of the BeSt study. Ann Rheum Dis 2006; 65(Suppl. 2):507.
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