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Researchers developed a SuperLearner framework that combines established epigenetic clocks with machine learning to compare DNA methylation-based aging in residents of Costa Rica’s Nicoya Blue Zone with other Costa Ricans. Initial calibration suggested a modest younger epigenetic age among Nicoyans, but accounting more closely for age distribution substantially reduced the apparent advantage, highlighting the importance of population-specific calibration in longevity research.

Interviews with 11 healthcare professionals in a UK specialist weight management service found generally positive attitudes toward injectable GLP-1 drugs, alongside limited formal training and uncertainty about how the medications should be integrated with behavioral care. Participants anticipated potential benefits for confidence and weight management but also raised concerns about treatment discontinuation, behavioral engagement, and evolving professional responsibilities.

Pertussis, or whooping cough, continues to cause periodic outbreaks worldwide and can be especially dangerous for infants who have not completed vaccination.

Do you ever feel like sometimes you can master a new dance step almost immediately, while other times you struggle to nail it despite repeated practice? This might be due to skill or effort, but also to something less obvious: whether the brain is in a state that allows learning to take hold.

Nicotine e-cigarettes are more effective in helping people quit smoking than many conventional methods such as nicotine gums and patches and quitting with behavioural support or no support at all, an updated Cochrane review finds.

A critical narrative review found that healthy diets, regular physical activity, strong social ties, and psychological well-being can support healthier aging and reduce premature mortality, but none has been shown to reliably determine who reaches 100. The authors argue that exceptional longevity arises from complex interactions among biological resilience, genetics, social and environmental conditions, lifelong exposures, and chance rather than any universal lifestyle formula.

Millions of cases of tooth decay could be prevented if Australia introduced a 20 per cent tax on sugar, new Griffith University research has found.

Building on recent discoveries about the adult thymus, Mass General Brigham investigators used artificial intelligence to show that incidental radiation exposure to the thymus may influence outcomes in patients with lung cancer.

A multicenter Japanese study found that symptomatic uncomplicated diverticular disease (SUDD) was associated with reduced gut microbial diversity, increased abundance of the Ruminococcus gnavus group, and depletion of Coprococcus and other butyrate-producing bacteria. Predictive microbiome analysis also identified enrichment of pathways linked to exopolysaccharide biosynthesis and the cell cycle, although the observational design means these associations cannot establish causality.

Until recently, the thymus was thought to be of little use beyond puberty, but new research has shown that radiation to the organ is associated with worse outcomes in patients being treated for non-small cell lung cancer (NSCLC).

Diet-induced weight loss significantly reduced predicted 10-year risks of major adverse cardiovascular events and type 2 diabetes in healthy premenopausal women with overweight, regardless of whether aerobic or resistance exercise was added. Some of these gains diminished as weight was partially regained over the following year, although greater exercise adherence was associated with less rebound in predicted diabetes risk.

Black parents who experienced higher levels of appropriated racial oppression - defined as shaping one's behavior and self-concept around dominant cultural norms of whiteness - were less likely to transmit positive, culturally protective messages that affirmed racial pride and self-worth to their adolescent children, a recent study found.

Researchers have developed a "scaffold" that mimics natural tissue and could lead to more durable rotator cuff repairs, including for large injuries and cases involving bone and tissue degeneration that are often the most difficult to fix.

How do we decide what to do when faced with choices? And how does the brain adapt those decisions as the world around us changes? A new study published in Nature by researchers at Baylor College of Medicine and Duncan Neurological Research Institute at Texas Children's Hospital offers surprising insights by revealing how the human brain continuously balances competing goals in real time.

Natural wild-derived microbiota protected mice against diet-induced obesity across sexes, genetic backgrounds, and age by increasing energy expenditure and promoting a thermogenic program in brown adipose tissue. The effect depended on the immune system’s initial encounter with the microbiota and required CCR2-associated myeloid activity, revealing a long-lasting microbiota-immune-brown fat pathway.

University of Oregon biologists have resurrected prehistoric proteins up to 160 million years old that carry natural antimicrobial properties.

Venomous snake bites can cause illness, disability and death in tropical and subtropical regions. A study published on August 25th in PLOS Medicine by Dileepa Ediriweera and Anuradhani Kasturuiratne at the Liverpool School of Tropical Medicine, UK, and the University of Kelaniya, Sri Lanka, and colleagues suggests that the incidence of snake envenoming and snakebite mortality is much higher than previously estimated.

Patients diagnosed with conditions after an emergency hospital admission or an emergency room visit face a higher risk of death than those diagnosed in non-emergency settings, according to a large population-based study by Emma Whitfield and colleagues from University College London, UK, published August 25th in the open access journal PLOS Medicine.

In the years following type 2 diabetes diagnosis, women are more likely to develop mental health conditions, while men are more likely to develop cardiovascular and renal complications, according to a study published August 25th in the open access journal PLOS Medicine by Fabiola Eto from Queen Mary University of London, UK, and colleagues.

Following the Trump administration's 2018 announcement of changes to the public charge rule that would penalize immigrants for using public benefit programs, antisanctuary counties in the US saw a 16.8-percent increase in HIV cases among Hispanic populations, compared to baseline counties.