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Lactylation may drive pulmonary fibrosis through metabolic reprogramming pathways
Announcing a new article publication in BIO Integration. Pulmonary fibrosis (PF) is a progressive and irreversible interstitial lung disease that is characterized by destruction of alveolar architecture, excessive proliferation of fibroblasts, and aberrant deposition of extracellular matrix (ECM) but the precise pathogenesis has yet to be fully elucidated.
Early pregnancy interventions improve healthy gestational weight gain outcomes
Both too little and too much weight gain during pregnancy are associated with serious maternal and child health outcomes, including preterm birth, low birth weight, death, preeclampsia, and unplanned cesarean delivery.
Vaginal bromocriptine may ease pain and heavy bleeding in adenomyosis
A pilot randomized controlled trial found that vaginal bromocriptine reduced menstrual bleeding, pelvic pain, menstrual duration, and cycle irregularity in women with adenomyosis compared with routine treatment.
Study finds lower Alzheimer’s pathology in Black and Hispanic patients
A large multisite study of older people with cognitive impairment finds that Black and Hispanic people, while known to be far more apt to have dementia, are significantly less apt than other racial and ethnic groups to show Alzheimer's pathology on brain scans.
Major trial compares surgical approaches for treating Chiari malformation and syringomyelia
A nationwide study has shed new light on how to most effectively and safely treat Chiari malformation and syringomyelia, rare neurological diseases that impact both children and young adults.
New mathematical model tracks microbial contribution to human digestion
Food labels make calories seem simple. They show the number of calories per serving, which is calculated based on how much fat, carbohydrates and protein the food contains.
Study reveals inequities in wastewater-based disease outbreak detection systems
Wastewater surveillance was hailed during the COVID-19 pandemic as a more equitable way to track disease.
Ghrelin rises in depression despite obesity’s usual appetite-hormone suppression
Researchers found that both acylated and deacylated ghrelin were elevated in unmedicated adults with major depressive disorder and obesity compared with non-depressed adults with obesity. The cross-sectional findings suggest ghrelin-system dysregulation may be linked to depression in obesity, but larger longitudinal studies are needed to test whether ghrelin is a reliable biomarker.
Artificial intelligence reveals hidden fluid flow patterns in sleeping brains
When a person goes into deep sleep, waterlike fluid circulates around the brain, washing away metabolic waste that is linked to diseases such as Alzheimer's.
Aging immune system may destabilize the gut microbiome balance
Why does the gut microbiome lose its balance as we age? Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena now present a new explanation in a paper published in "PLoS Biology".
Heart health before pandemic influenced severity of COVID-19 infections
Better heart health before the pandemic was linked to a lower risk of severe COVID-19 events, according to research published today in the Journal of the American Heart Association, an open-access, peer-reviewed journal of the American Heart Association.
Smaller nanoplastics trigger stronger changes in brain neuron activity
Smaller plastic particles have more effects on neurons, the key information processing cells of the brain, new research from the University of Eastern Finland shows.
Can AI help build a fairer food system from farm to plate?
AI could help make food systems more personalized and climate-resilient by linking nutrition, health, farming, logistics, and sustainability data. The review highlights promise in precision nutrition, vertical farming, traceability, and smarter supply chains, while warning that privacy, equity, energy use, data silos, and governance gaps must be addressed.
Study suggests new potentially druggable ways to target GPCR signaling
A study published in Nature by researchers at Duke University School of Medicine identifies a new way that G protein–coupled receptors (GPCRs) - targets of roughly one-third of FDA-approved drugs - control signaling in cells.
True toll of long COVID may be double that of current estimates, research shows
The true toll of long COVID may be double that of current estimates and hidden from current surveillance systems that rely on capturing diagnostic codes, according to new research led by Mass General Brigham.
Persistent gut microbiome changes linked to sustained colorectal cancer risk
More than a decade after removal of an adenoma-a precancerous mass-from the colon, alterations to the gut microbiome and metabolites remain and may drive heightened risk of colorectal cancer (CRC), according to a new study led by researchers at Harvard T.H. Chan School of Public Health.
Extreme trait values often have simpler genetic explanations than thought
Researchers at the Icahn School of Medicine at Mount Sinai have found evidence that people who fall at the extreme high or low ends of certain traits, such as cholesterol, blood glucose, height, and age at menopause, are more likely to have a simple genetic explanation than previously thought.
Degrading mutant KRAS protein induces greater lung cancer regression
KRAS is one of the oncogenes most frequently altered in cancer, mutated in approximately one-third of lung adenocarcinomas.
Prenatal therapy for cystic fibrosis improves lifelong health outcomes
This Cystic Fibrosis Awareness Month, Children's Hospital Colorado (Children's Colorado) is highlighting a growing shift in care: starting cystic fibrosis treatment before birth to improve lifelong health outcomes and reduce hospital stays.
Study reveals how immune cells alter vascular plaque formation
A new LMU study shows how differently immune cells influence the formation of dangerous vascular deposits - and identifies miR-147 as a potential starting point for future therapies.




