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Targeted inhibition of a "signal jammer" protein may improve how tumors respond to immunotherapy. Published today in Nature, a new study demonstrates how some cancer cells use the protein voltage-dependent anion channel 2 (VDAC2) like a signal jammer to prevent the body's anticancer systems from communicating with the immune system.

While increased average life expectancy is a testament to modern medicine and public health efforts, an aging population comes with an increased presence of chronic diseases such as osteoporosis.

Mindfulness, total sleep quality, and alcohol consumption may help explain why people who stay up late have a greater risk of depression, according to a new study publishing March 19, 2025, in the open-access journal PLOS One by Simon Evans of University of Surrey, UK, and colleagues.

Researchers and pediatric neurosurgeons at the University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh developed a new way to profile brain cancers in children, paving the way for improved diagnostics and treatments.

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Dr. Andrés Hidalgo has discovered a specialized population of neutrophils in the skin that produce extracellular matrix, helping to maintain the skin's resistance and integrity.

By revealing for the first time what happens in the brain when an animal makes a mistake, Johns Hopkins University researchers are shedding light on the holy grail of neuroscience: the mechanics of how we learn.

For the first time, scientists have systematically analyzed somatic mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer.

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies.

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check.

A new study explains how a parakeet's brain helps it to mimic human words.

Campylobacter infections are the most common foodborne illnesses in the U.S., sickening an estimated 1.5 million people each year.

Heavy alcohol consumption is a leading cause of gastrointestinal diseases, with binge drinking linked to increased intestinal permeability-a condition commonly known as "leaky gut."

Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare for a second.

Australian food scientists have reclassified dietary fibers – beyond just soluble and insoluble – to better guide nutritional decisions and drive targeted health food products.

Some individuals who have had anterior-cruciate-ligament reconstruction (ACLR), the kind of surgery often performed on athletes' knees, may develop early-onset knee osteoarthritis.

A recent study by the University of Eastern Finland shows that barriers to accessing social and medical services among older immigrants and immigrants with dementia in Finland are interconnected.

Electronic cigarettes use may pose lower cardiovascular risks in people living with HIV compared to tobacco cigarette use, new UCLA-led research shows.

Every year, millions of family members and friends provide care for loved ones undergoing cancer treatment, often at great emotional cost.

Published in The Lancet Child & Adolescent Health, the study aimed to provide robust insights into adolescent mental health trajectories in two different cultural contexts by comparing large samples of 11 to 16 years olds in London and Tokyo over time.

Between 1999-2021, U.S. adolescents steadily desisted from risky behaviors such as substance use and violence, and from reporting a combination of both risky behaviors and mental health symptoms.