Rss Feed
Engineering muscle stem cells for sustainable cultured meat production
The production of cultured meat depends on the isolation, expansion, and differentiation of animal stem cells into edible tissues. Muscle stem cells, or satellite cells, are central to this process due to their ability to regenerate and form muscle fibers.
Cryo-EM reveals NPFFR1 activation and guides novel ligand design
This study investigates the molecular mechanisms underlying ligand recognition, subtype selectivity, and activation of neuropeptide FF receptor 1 (NPFFR1)-a Gi/o-coupled receptor that responds to endogenous RF-amide peptides (RFRP-3 from pro-NPFFB, NPFF from pro-NPFFA) and regulates physiological processes like opioid function, pain, and energy homeostasis.
Single-cell RNA-seq reveals FBLN7's role in adipose tissue fibrosis
Fibrosis, resulting from excess extracellular matrix (ECM) deposition, is a feature of adipose tissue (AT) dysfunction and obesity-related insulin resistance.
Lowering blood sugar reduces heart risk in prediabetes
Lowering blood sugar levels halves the likelihood of serious heart problems in people with prediabetes.
Genetic differences in surfactant proteins influence retinopathy of prematurity risk
A new study from the University of Oklahoma suggests that small genetic differences in two proteins – previously known for their role in premature infants' lungs – may also influence how their eyes develop, potentially affecting the risk of retinopathy of prematurity (ROP).
Virus shells use asymmetry to control RNA release and infection
Viruses are typically described as tiny, perfectly geometric shells that pack genetic material with mathematical precision, but new research led by scientists at Penn State reveals a deliberate imbalance in their shape that helps them infect their hosts.
SN101 iPSC-derived therapy relieves chronic pain and preserves joints
SereNeuro Therapeutics, a preclinical biotechnology company developing non-opioid pain therapies, unveiled new data today on a novel approach to chronic pain management and joint tissue preservation.
Over-contracted gut muscles drive gastrointestinal symptoms in myotonic dystrophy
Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also affects other organs, including the brain, heart and gastrointestinal (GI) tract.
Young tanning bed users show accelerated genetic aging in the skin
Tanning bed users are known to have a higher risk of skin cancer, but for the first time researchers have found that young indoor tanners undergo genetic changes that can lead to more mutations in their skin cells than people twice their age.
Human heart organoids enable new therapies for atrial fibrillation
Though an estimated 60 million people around the world have atrial fibrillation, or A-fib, a type of irregular and often fast heartbeat, it's been at least 30 years since any new treatments have been developed.
Interdisciplinary project aims reduce noise exposure for premature children in neonatal care
Premature babies are particularly susceptible to strong sensory impressions and high sound levels from the incubator. Now researchers will look at what can be done to protect children's hearing and development.
Pediatric critical care survivors often lack prompt primary care follow up
When the unthinkable happens and a child is left critically ill or injured, the miracle workers in pediatric intensive care units around the country work tirelessly to save their lives.
Immune checkpoint inhibitors can trigger rare immune thrombocytopenia in cancer patients
Researchers led by investigators at Mass General Brigham have published valuable information about a rare but serious complication of anti-cancer immunotherapy, providing the first large-scale description of its risk factors and clinical course, and underscoring the importance of early diagnosis and treatment.
Early relapse predicts poor survival in mature nodal T-cell lymphoma
Mature nodal T-cell lymphoma is a type of rare and aggressive blood cancer. Limited data make it difficult to identify high-risk patients or tailor treatment strategies, so most patients receive similar care despite differences in disease characteristics and outcomes.
Exploring melatonin therapeutic potential in systemic lupus erythematosus
A recent review published in Current Molecular Pharmacology explores the therapeutic potential of melatonin in systemic lupus erythematosus (SLE), a complex autoimmune disease affecting multiple organs.
Glycation stress drives aortic stiffening through oxidative stress and senescence
A new research paper was published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled "Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence."
Novel nanomedicine mPEG@ELA-11 shows potential in treating atherosclerosis
A pioneering study led by researchers from Tongji University School of Medicine, Shanghai Jiao Tong University School of Medicine and Naval Medical University has unveiled a novel nanomedicine, mPEG@ELA-11, which demonstrates significant potential in treating atherosclerosis (AS), a leading cause of cardiovascular diseases globally.
Nighttime heart attacks cause less damage due to neutrophil circadian rhythms
Heart attacks that occur at night are less severe than those that strike during the day. A new study from the Centro Nacional de Investigaciones Cardiovasculares (CNIC) explains why. Published in the Journal of Experimental Medicine, the study led by Dr. Andrés Hidalgo's group at the CNIC shows that neutrophils-a type of white blood cell-have an internal clock that regulates their aggressiveness throughout the day and determines the extent of damage they cause to the heart after a heart attack.
Autoimmune attack on CASPR2 drives nerve hyperexcitability and involuntary muscle activity
A scientific review on autoimmune neurological diseases reveals what occurs in our body when the immune system, by mistake, produces antibodies that target a protein essential for the normal functioning of nerves.
Metabolic imaging enables early response prediction in bone-dominant metastatic breast cancer
A prospective, multicenter cancer clinical trial by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) has validated an improved method for predicting treatment benefits in patients with hormone receptor-positive (HR+) metastatic breast cancer that has spread primarily or exclusively to the bones.




