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Digestive system malignancies (DSMTs)-including esophageal, gastric, colorectal, liver, and pancreatic cancers-represent a major public health challenge in China.

Cuproptosis represents a novel mechanism of cell death characterized by intracellular copper ion accumulation.

An experimental mRNA vaccine boosted the tumor-fighting effects of immunotherapy in a mouse-model study, bringing researchers one step closer to their goal of developing a universal vaccine to "wake up" the immune system against cancer.

As millions of people know firsthand, the most common side effect of mRNA vaccines like the COVID-19 shot is inflammation: soreness, redness and a day or two of malaise.

A new study sponsored by Mirvie, which is the first to evaluate U.S. Preventive Services Task Force (USPSTF) guidelines for preeclampsia risk and aspirin prescription in a single, nationally representative, prospective population, found while high-risk factors had sufficient value in estimating risk, there's limited value for the moderate risk category - leading to nonspecific recommendations for aspirin use, a recognized prevention tool.

Two junior research groups at Ruhr University Bochum, Germany, have developed a drug complex that kills cancer cells in such a clever manner that they raise a red flag as they die. They signal to the immune system that something is seriously wrong with this type of cell.

In a major advance for patients with Crohn's disease, a new study led by researchers at Mount Sinai Health System found that guselkumab, a medication with a mechanism of action that is new to inflammatory bowel disease (IBD) treatment, outperformed an established standard of care in promoting intestinal healing and symptom relief.

Vitamin D is not only an essential nutrient, but also the precursor of the hormone calcitriol, indispensable for health: it regulates the uptake of phosphate and calcium necessary for bones by the intestines, as well as cell growth and the proper function of muscles, nerve cells, and the immune system.

Patients with heart failure and atrial fibrillation (AF) at the time of mitral transcatheter edge-to-edge repair (M-TEER) for severe mitral regurgitation are more than twice as likely to die or be rehospitalized for heart failure, compared to patients without AF.

"Complex processes are going on in the brain when we sleep," says Dr Karolina Armonaitė, a neuroscientist from Kaunas University of Technology, Lithuania. According to her, a more precise understanding of what happens in different areas of the cerebral cortex during sleep can help diagnose sleep disorders and neurological diseases more accurately.

A new study led by researchers from the University of Eastern Finland and a team of international collaborators shows that dengue outbreaks in Medellín, Colombia, are strongly linked to patterns of urban development and socioeconomic status.

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Chronic obstructive pulmonary disease (COPD) and abdominal aortic aneurysm (AAA) are both severe conditions with complex etiologies and substantial comorbidities.

GLP-1 weight-loss drugs are changing how people date and connect. In a nationally representative survey of 2,000 single U.S. adults (ages 18 to 91) led by the Kinsey Institute at Indiana University with DatingNews.com, GLP-1 users reported a wide range of physical, social, and psychological shifts they attributed to the drug.

Three studies presented today at the Society of NeuroInterventional Surgery's (SNIS) 22nd Annual Meeting discussed whether using GLP-1 inhibitors could lessen the impacts of stroke and related brain injuries or reduce the risk of stroke altogether.

A new Yale study has revealed that neurons - the energy-hungry cells that connect and direct activity in the brain - are equipped with "backup batteries" that kick in to keep the brain running during periods of metabolic stress.

Human eggs are some of the most patient cells in the body, lying dormant for decades until needed. A study published today in The EMBO Journal shows that the cells deliberately slow the activity of their internal waste disposal systems as they mature, most likely an evolutionary design which keeps metabolism low and damage at bay.

Scar tissue in the heart was associated with abnormal heart rhythms among healthy, long-time male endurance athletes age 50 or older, potentially increasing their risk of sudden cardiac death, according to a small study published today in Circulation: Cardiovascular Imaging, an American Heart Association journal.

In light of reports from the White House that President Donald J. Trump has been diagnosed with Chronic Venous Insufficiency (CVI), the American Heart Association is sharing important information on the condition and its association with cardiovascular risk factors, disease and increased risk of death.

A protein called PAR1 helps lymphatic vessels structurally transform to boost fluid drainage and support healing when the lungs are injured according to researchers from Weill Cornell Medicine.

The use of social media is contributing to declining attention spans, emotional volatility, and compulsive behaviors among young people, reveals a new report by Nanyang Technological University, Singapore (NTU Singapore) and Singapore-based research agency Research Network, in collaboration with US-based AI platform ListenLabs.ai.