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Engineers at the University of Pennsylvania and Rice University have refined a technology for editing individual genetic "base pairs" to a new level of precision, opening the door to safer, more reliable therapies for a wide range of genetic diseases, and to potential treatments for some cystic fibrosis patients that may yield better outcomes than existing therapies.

For more than six decades, biomarker-based newborn screening has played a pivotal role in reducing infant mortality and long-term disability by enabling early detection of metabolic and endocrine disorders.

In a study of adults with cancer, those who developed a mental health condition within the first year after their cancer diagnosis had a higher likelihood of dying over the next few years.

Coronary artery disease (CAD) is the most common cause of death globally. In CAD, plaques composed of cholesterol, fats, calcium and other compounds accumulate and create obstructions in the coronary vessels that supply blood to the heart.

SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression.

An analysis co-led by Josefa A. Antón Ruiz, a researcher from the Department of Health Psychology at the University of Alicante (UA), reveals that 43.5% of healthcare professionals experienced clinically significant symptoms of insomnia during and after the COVID-19 pandemic.

Loughborough University and Science in Sport (SiS) have announced a renewed three-year partnership, strengthening the organizations' long-standing collaboration across elite sport and performance nutrition.

New findings reveal bilingual mother-child interactions enhance neural synchrony, highlighting the role of play over language in early cognitive development.

The use of antipsychotic medications for purposes other than those officially approved is common among older adults in Finland.

Antimicrobial resistance poses a growing global health crisis, with few new antibiotics in development.

Chronic hypoxia improves glucose tolerance in mice through insulin-independent mechanisms, with red blood cells acting as a major systemic glucose sink. Increased erythrocyte production and altered glycolytic flux help reduce circulating glucose while supporting oxygen delivery to tissues.

This systematic review in Nutrients evaluates human studies investigating whether polyphenol-rich berry consumption can modulate obesity-related metabolic dysfunction and support cognitive performance, particularly in individuals at risk of mild cognitive impairment. Evidence suggests modest memory benefits and possible metabolic improvements, although biomarker findings and long-term clinical relevance remain uncertain.

Emerging evidence suggests reduced plasma PPP2R5C levels may serve as an early indicator of Alzheimer’s disease before overt clinical symptoms appear. The protein appears linked to tau regulation, autophagy pathways, and cognitive decline, supporting its potential diagnostic relevance.

When you scratch an itch, something tells your brain when to stop. That moment of relief, when scratching feels "enough," is not accidental.

When you step outside on a winter morning or pop a mint into your mouth, a tiny molecular sensor in your body springs into action, alerting your brain to the sensation of cold.

Researchers developed plasma p-tau217–based clock models that estimate when cognitively unimpaired individuals with Alzheimer’s pathology may develop symptomatic disease. The models predicted symptom onset within about three to four years and may help improve clinical trial selection while remaining unsuitable for individual clinical decisions at present.

The tiny fatty capsules that delivered COVID-19 mRNA vaccines into billions of arms may work better when they're a little disorganized.

Scientists have uncovered an elegant biophysical trick that tuberculosis-causing bacteria use to survive inside human cells, a discovery that could lead to new strategies for fighting one of the world's deadliest infectious diseases.

As space agencies prepare for human missions to the Moon and Mars, scientists need to understand how the absence of gravity affects living cells.

Proteins long known to be essential for hearing have been hiding a talent: they also act as gatekeepers that shuffle fatty molecules across cell membranes.