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The cessation of GLP-1RAs is linked to a 60% weight regain within a year, emphasizing the importance of tailored strategies for effective long-term weight loss.

Humans often adapt their behavior to that of other people with lightning speed. A new study by the University of Zurich reveals what brain networks govern social mentalization and adaptation, making it possible to predict how flexibly one person reacts to others.

Researchers have discovered that mutations in the FOXJ3 gene act as a "master switch" failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy.

Every time we feel a gentle tap on the skin, specialized nerve cells convert that physical force into an electrical signal that the brain can interpret as touch. While scientists have long known that a protein called PIEZO2 acts as a key sensor for touch, it remained unclear why PIEZO2 is specialized for the localized mechanical forces experienced by sensory neurons, whereas its close relative PIEZO1 responds to broader mechanical stresses such as those generated when cells stretch, as occurs in blood vessels.

Neuroscientists at King's College London have pinpointed a mechanism behind the increased neural connectivity observed in the very early stages of Alzheimer's disease.

Age is more than just one number. While neuroscientists used to think of cognitive aging as a single trendline, they now realize that vast individual differences require a more predictive and personalized approach. As they uncover more factors that affect cognition over time, they are realizing that modeling the aging brain requires more diverse data than traditionally captured.

Dental pulp regeneration remains a major clinical challenge. Researchers have discovered that SMAD7 directly forms a transcriptional complex with β-catenin in human dental pulp stem cells, activating Wnt signaling and promoting regenerative gene expression.

Artificial intelligence (AI) has the potential to redefine how radiology is practiced, as well as highlight specific challenges for radiology departments, according to new research from the Journal of the American College of Radiology (JACR).

A new study published in Neurology and led by Queen Mary University of London, has revealed that people of South Asian, African and European ancestry share many of the same genetic risk factors for multiple sclerosis (MS).

In recent years, rates of childhood obesity have been rising, with the U.S. Centers for Disease Control estimating in 2024 that approximately one in five children and adolescents met the clinical definition of obese.

In little moments like when sipping coffee or licking an ice cream cone, it doesn't seem like your body is pulling off a biological miracle. But it is. That cookie is not you-yet when you put it in your mouth, your body is able to tolerate it and process it without any detriment to your health in a process called oral tolerance. How does the human body make that decision between tolerance and rejection?

A large cohort study of more than 600,000 US veterans with type 2 diabetes found that initiating GLP-1 receptor agonists was associated with lower risks of developing substance use disorders compared with SGLT-2 inhibitors. Among veterans with existing substance use disorders, GLP-1 receptor agonist use was also linked to fewer overdose events, hospitalizations, and suicide-related outcomes.

A large longitudinal study of U.S. adults found that many older people improve in cognitive function or walking speed over time, challenging the idea that aging inevitably leads to decline. Positive beliefs about aging were associated with higher odds of improvement in both cognitive and physical health.

Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular resilience. The study proposes somatic genomics as a powerful strategy to uncover disease mechanisms and identify new therapeutic targets across multiple conditions.

esearchers developed MedVersa, a generalist multimodal AI model trained on tens of millions of medical imaging instances to perform diverse radiology tasks within a single framework. The model matched or exceeded specialist AI systems across several benchmarks and produced radiology reports comparable to human reports in many cases while improving reporting efficiency.

The University of Oklahoma's Native Nations Center for Tribal Policy Research recently released a new Sovereign Report titled "Purchased/Referred Care and Cancer: Overview and Options for Tribal Consideration."

Researchers at the University of Colorado Anschutz have identified a critical gap in how post-amputation pain is evaluated and treated.

GLP-1s are building a reputation as "wonder drugs." First characterized for their ability to improve insulin release and treat diabetes, the drugs were later found to promote weight loss and improve cardiovascular health.

Researchers at the Cancer Research Institute and the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have uncovered a critical mechanism that enables gastric cancer to spread to distant organs.

Florida Atlantic University has received a $2.4 million grant from the National Institutes of Health to investigate how an immune-related receptor in neurons plays a fundamental role in brain function, behavior and psychiatric health.