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Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, playing a central role in modulating T-cell activation and immune tolerance, and its inhibition enhances T cells and NK cells function, also provides a strategy for the function restoration of exhausted T cells.

A study led by McMaster University researchers shows that a widely available and inexpensive medication not only prevents potentially serious stomach bleeding in critically ill patients, but also saves hospitals thousands of dollars.

Scientists have long known that bacteria come in many shapes and sizes, but understanding what those differences mean has remained a major challenge, especially for species that can't be grown in the lab. Now, a new study led by Nina Wale, an Assistant Professor in MSU's Department of Microbiology, Genetics, & Immunology, introduces a groundbreaking method that could change how researchers study bacterial diversity.

Long before the alarm sounds, many Americans lose quality rest to the quiet worries that surface after dark - whether about bills, the next paycheck or job stability. New research from Rice University shows those bedtime stress moments aren't just uncomfortable; they're part of a measurable pathway connecting economic stress to poor sleep.

Sweat contains a wealth of biological information that, with the help of artificial intelligence and next-generation sensors, could transform how we monitor our health and wellbeing, a new study suggests.

In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together.

People with Long COVID use the health service significantly more than they did before their diagnosis. These patients need to use GP, outpatient, inpatient and emergency department services more than people in other control groups - and the costs of their healthcare use have more than doubled.

Total hip arthroplasty (hip replacement) is a common treatment for hip osteoarthritis, a degenerative joint disease caused by cartilage in the hip joint wearing down.

Researchers led by a team from Mass General Brigham and the Ragon Institute have discovered why some people living with HIV who are given a treatment called broadly neutralizing anti-HIV antibodies (bNAbs) can safely stop taking standard, lifelong HIV medications and maintain control of the virus for years, while others given the same treatment do not achieve this remission.

A Johns Hopkins Medicine study involving a dozen people with the inflammatory skin disease hidradenitis suppurativa (HS), which mostly affects skin folds, is believed to be the first to provide evidence that hormone-disrupting chemicals commonly found in ultra-processed food and single-use water bottles may contribute to the development of or worsen the condition in some people.

A research team at the Max Planck Institute for Metabolism Research has found that the smell of fatty foods during pregnancy increases the risk of overweight and obesity in children.

Some brain disorders are straightforward, such as the direct frontal lobe assault of a concussion or traumatic brain injury. Others, like Alexander disease, are akin to guerilla warfare.

More than three-quarters of the global population aren't getting enough Omega-3, according to new research from the University of East Anglia, the University of Southampton and Holland & Barrett.

When uncontrolled wildfires moved from the foothills above Los Angeles into the densely populated urban areas below in January 2025, evacuation ensued and a thick layer of toxic smoke spread across the region. Air quality plummeted. Local hospitals braced for a surge, but it never came.

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the protective caps at the chromosome ends-those caps eventually become too short to prevent chromosome ends from being recognized as DNA breaks.

Obstructive sleep apnea and atrial fibrillation are two conditions that share a potentially deadly link. Having one increases the odds of developing the other, and together, the breathing difficulties of sleep apnea combined with the irregular heartbeat of atrial fibrillation (AFib) can result in life-threatening cardiovascular risks.

Researchers at Children's Hospital of Philadelphia (CHOP) found that circadian rhythms – the biological clocks of the body – can influence outcomes related to influenza infections, providing clinicians with insight about how biological processes can be used to optimize care for critically ill patients with respiratory viral infections.

Parks, libraries, recreation centers, and sidewalks, ideally, would serve to improve the quality of living for residents, but it is not that simple, especially for youth. Research by Melissa Villodas, whose work focuses on understanding how social determinants of health impact the mental health of vulnerable young people, reveals that the relationship between neighborhood amenities and youth mental health is much more complex.

Scientists at The University of Texas at El Paso have found a promising new target in the fight against high-grade serous carcinoma, an aggressive form of ovarian cancer.

A new generation of targeted treatments and gentler chemotherapy options for older adults with a new diagnosis of acute myeloid leukemia (AML) is driving better survival and cure rates.