Feed aggregator

LUAD is the most common histological subtype of lung cancer. Although surgery can be curative for patients diagnosed at an early stage, approximately 30%-50% develop recurrence or aggressive metastasis within five years.

After treatment for metastatic prostate cancer, a drop in prostate-specific antigen (PSA) levels in the blood is an indicator that the treatment is working.

A new study that explores gene expression during heart transplant rejection marks a step forward for precision medicine approaches to treat organ rejection.

Every year, more than 120,000 newborns worldwide contract HIV, a global health burden that requires lifelong treatment for millions of people - assuming they have access and can afford it.

The world-first trial of a fridge-free tetanus-diphtheria vaccine at University Hospital Southampton (UHS) has produced encouraging results that could improve access worldwide to crucial treatments.

Doctors may think they're saying "Don't panic." But many patients hear "Don't bother" instead.

In a US cohort of 52,971 adults with type 2 diabetes and established atherosclerotic cardiovascular disease, tirzepatide initiation was associated with a lower one-year risk of major adverse cardiovascular events than sitagliptin. The benefit was driven mainly by lower myocardial infarction and all-cause mortality hazards, although the authors cautioned that mortality findings may be influenced by residual confounding.

A long-term study of 12,409 adults found that a greater burden of diabetes, hypertension, and current smoking in midlife was associated with substantially fewer years lived free of dementia. Adults with none of these risk factors had about 30.1 dementia-free years from age 55, compared with 17.5 years among those with all three, a difference of nearly 13 years.

A single 25-mg dose of psilocybin with psychological support was feasible to deliver within an NHS setting and produced large preliminary reductions in depressive symptoms among adults with treatment-resistant depression. The Phase 2 feasibility trial also found the treatment was generally well tolerated, although functional unblinding and expectancy effects mean larger, longer efficacy studies are needed.

Researchers created T2T-HG002, a near-perfect diploid human genome benchmark that is free of detectable errors across 99.4% of the genome and captures both maternal and paternal haplotypes. The benchmark expands coverage into previously excluded genomic regions and provides a new framework for evaluating sequencing reads, assemblies, phased variants, and personalized genome inference.

A study of 4,818 middle-aged and older Chinese adults found that higher light BioAge was associated with greater risks of cognitive impairment, episodic memory decline, and reduced mental intactness. The simple measure, based on age, creatinine, glucose, and CRP, added modest predictive information but requires further validation before clinical use.

A narrative review finds that pulses may support gut and metabolic health through their fiber, protein, phytochemicals, and interactions with the gut microbiota, while offering a lower environmental footprint than many animal protein sources. Human evidence is strongest for selected cardiometabolic outcomes, while many microbiome and fermentation-related benefits remain supported mainly by animal and laboratory studies.

A nationwide geospatial analysis of 151,366 publicly accessible parks found that 52.6% lay within two miles of at least one industrial facility reporting toxic chemical management to the EPA, while 17.7% had parkland within two miles of a current or former Superfund site. The study mapped proximity rather than contamination or exposure, highlighting locations where targeted environmental assessment and healthier urban planning may be warranted.

While Black and Hispanic families are enthusiastic about research participation, other provider- and systems-focused factors may influence their involvement in pediatric oncology clinical trials, a UT Southwestern Medical Center-led study has found.

Immune checkpoint inhibitors, cancer vaccines and cellular therapies have reshaped oncology, yet most patients still do not achieve lasting benefit.

Understanding how heart muscle cells stop dividing and acquire the characteristics needed to sustain lifelong cardiac function remains one of the greatest challenges in cardiovascular biology.

Women live longer than men in nearly every country in the world, yet they experience higher rates of disability, dementia and many other age-related conditions.

The prefrontal cortex, a brain region long associated with learning more flexible behaviors, can sometimes block the ability to think outside the box, a new study in mice shows.

Researchers at Duke University School of Medicine are investigating how to keep opioids' pain-relieving benefits while reducing their addictive potential. In a study published in Nature, they report a step toward that goal.

Malaria kills more than half a million people a year, most of them young children in Africa. Two vaccines are now recommended by the World Health Organization, RTS,S and R21.