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Simple hand grip test may reveal your future obesity risk
Increased grip strength correlates with lower obesity-related disease risk, suggesting muscle power as a key factor in preclinical obesity management.
Yogurt’s impact on bone health falls short of fracture protection, review finds
This systematic review and meta-analysis found that while yogurt consumption shows a modest positive association with bone health markers, its effect on bone mineral density and fracture prevention in adults is clinically negligible. Current evidence is based solely on observational studies, with low certainty and limited characterization of yogurt products.
Mediterranean-style diets improve pelvic floor function and sexual health, review finds
This systematic review and meta-analysis of 31 studies reveals that healthy, anti-inflammatory dietary patterns, particularly the Mediterranean and DASH diets, are linked to improved sexual function and reduced incontinence symptoms in pelvic floor dysfunction. However, prospective evidence for incontinence improvement remains limited, suggesting that benefits may be mediated by metabolic and inflammatory pathways, especially in individuals with obesity or metabolic syndrome.
Low-calorie diets linked to higher psoriatic arthritis risk, genetic study suggests
This Mendelian randomization study found that low-calorie diets may slightly increase the risk of psoriatic arthritis, while vegetarian and gluten-free diets showed no causal links to psoriasis, acne, or atopic dermatitis. The findings challenge assumptions about universally beneficial dietary patterns and highlight the need for cautious interpretation of dietary interventions in inflammatory skin disease.
MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer
Researchers developed seven MRI-based biological age clocks across major organs using UK Biobank imaging, linking each to proteins, metabolites, genetics, disease risks, mortality, and cognitive decline. These organ-specific age gaps reveal how uneven aging shapes vulnerability to conditions such as diabetes, hypertension, and dementia, opening new paths for precision prevention and clinical trial stratification
Children with multiple long-term conditions face nearly threefold higher COVID-19 mortality
Individuals with multiple long-term conditions are two and a half times more likely to die following COVID-19 infection than others.
New antibody drug conjugates can transform early HER2-positive breast cancer treatment
In a landmark moment at the ESMO Congress 2025, pivotal studies have unveiled compelling evidence that a new class of anti-cancer agents-antibody-drug conjugates (ADCs)-can dramatically improve outcomes for patients with early-stage HER2-positive breast cancer.
Nanoparticles offer new hope for treating alcohol-related liver disease
Across the world, more than 1.5 billion people suffer from chronic liver disease. The U.S. Centers for Disease Control and Prevention reports that it kills more than 52,000 people a year in the United States alone - the ninth most common cause of death in the nation.
Nanoplastics with environmental coatings can sneak past the skin's defenses
Plastic is ubiquitous in the modern world, and it's notorious for taking a long time to completely break down in the environment - if it ever does.
Study reveals how a microglial mutation increases risk for Alzheimer's disease
Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer's Disease by Impairing Microglial Function."
Study highlights the emotional and social challenges of stroke recovery
Nirupama Yechoor, MD, MSC, of the Department of Neurology at Massachusetts General Hospital, is the senior author of a paper published in JAMA Network Open, "Coherence of Stroke Survivors' Lived Experiences and the Stroke Specific Quality of Life Scale."
European societies launch EndoCompass to guide the future of endocrine research
The European Society for Endocrinology (ESE) and the European Society for Paediatric Endocrinology (ESPE) have released today, 17 October 2025, the EndoCompass Research Roadmap: Directions for the Future of Endocrine Science.
CRATERs identified as key sites for T cell-mediated tumor destruction
Like the surface of the moon, new research published today in Cell finds the existence of craters on the surface of melanoma cells that serve as immune hubs, becoming major sites for tumor killing. These craters could serve as good markers for immunotherapy success.
Supportive signals during pregnancy ease return-to-work transition for women
Returning to work after maternity leave can leave new mothers wrestling with guilt – feeling they can't fully win at work or home.
Researchers achieve proof of concept for generating eggs from somatic cells
Researchers at Oregon Health & Science University have accomplished a unique proof of concept to treat infertility by turning skin cells into eggs capable of producing early human embryos.
Review reveals how paternal lifestyle shapes sperm epigenetics and offspring health
A new review in Clinical Epigenetics synthesises growing evidence that paternal lifestyle and environmental exposures such as diet, obesity, smoking, endocrine-disrupting chemicals, and stress alter sperm epigenetic marks (DNA methylation, histone retention, and small non-coding RNAs).
Runx1 overexpression triggers early intervertebral disc degeneration
A new research paper was published in Volume 17, Issue 9 of Aging-US on September 8, 2025, titled, "Runx1 overexpression induces early onset of intervertebral disc degeneration."
Restoring pleiotrophin shows promise for improving brain function in Down syndrome
Faulty brain circuits seen in Down syndrome may be caused by the lack of a particular molecule essential for the development and function of the nervous system, new research suggests.
Pin1 inhibitors could reduce or stop outbreaks of herpes simplex virus 1
A class of antivirals called Pin1 inhibitors could reduce or stop outbreaks of herpes simplex virus 1 (HSV-1), the common infection behind oral herpes, according to new research published in Antiviral Research on July 25.
How age influences the perception of ambiguous facial expressions
Do you find it easy to perceive people you meet as happy and positive? Or are you vigilant and look for signs of dissatisfaction and anger in their facial expressions?