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Alzheimer's disease (AD) often begins long before it is clinically recognized, with subtle brain changes emerging years before noticeable memory loss or cognitive decline.

Melanoma is one of the deadliest forms of skin cancer, due in large part to its ability to rapidly develop resistance to treatment.

Graphic anti-smoking ads can lead smokers to reconsider their habit, but in the absence of similar warnings for e-cigarettes, they make some smokers more inclined to vape than quit.

Evening coffee has sparked controversy for years. Some people fall asleep without difficulty, while others toss and turn for half the night.

A new Finnish study shows that blood markers of dysfunctional lipid metabolism are associated with poorer cognitive function in 15-17-year-olds.

An EHU-University of the Basque Country and Biogipuzkoa Health Research Institute study has linked certain chemicals measured during the first trimester of pregnancy to the subsequent onset of puberty in the children.

Immunotherapies such as so-called checkpoint inhibitors activate the body's own immune system to fight cancer cells and have revolutionized the treatment of many types of tumor.

​Cancer scientists have discovered that lung cancer cells can change their identity to resist treatment.

Exposure to cancer risk factors in the workplace remains an important and preventable cause of disease in Europe.

Better heart health before the pandemic was linked to a lower risk of severe COVID-19 events, according to research published today in the Journal of the American Heart Association, an open-access, peer-reviewed journal of the American Heart Association.

A study on 42,759 menstrual cycles shows that sleep quality affects menstrual health, with implications for physiological stability and individual variability.

As professional baseball sees another high-profile elbow injury with Toronto Blue Jays right-hander José Berríos having undergone ulnar collateral ligament (UCL) surgery, new research from the University of Waterloo suggests many pitchers may be able to reduce stress on their elbows without sacrificing velocity.

This review examines how sex-specific blood pressure trajectories are shaped by genetics, hormones, metabolic risk factors, lifestyle exposures, environmental stressors, and medical treatments. It highlights that women generally have lower blood pressure earlier in life but may experience steeper increases with aging, especially around and after menopause, with exogenous stressors appearing to have a greater impact in women than in men.

Chikungunya ('to become contorted' in the Kimakonde language, named after the characteristic joint ache) is classified as one of the neglected tropical diseases by the World Health Organization.

This review examines how gut keystone bacteria shape microbiome stability, disease risk, and responses to diet. It highlights why better identification methods, experimental validation, and precision diet-probiotic strategies are needed to restore gut homeostasis.

With the arrival of warmer weather across the United States, outdoor enthusiasts are returning to America's parks and forests to hike and run on the country's beautiful, often remote, networks of trails.

A phase 1 NEJM interim analysis found that a single infusion of the investigational base-editing therapy VERVE-102 produced dose-dependent reductions in circulating PCSK9 protein and LDL cholesterol in adults with heterozygous familial hypercholesterolemia or premature coronary artery disease.

A scientific review published today in the NEJM Evidence journal, coordinated by the D'Or Institute for Research and Education (IDOR), evaluated outcomes of adults with community-acquired pneumonia (CAP) admitted to intensive care units (ICUs) in middle-income countries.

Retatrutide altered circulating metabolites and lipids linked to fatty acid oxidation and insulin resistance in people with obesity, with or without type 2 diabetes. These biomarker changes suggest improved metabolic health, but the post-hoc analysis remains hypothesis-generating and does not prove direct clinical benefit.

Cancer tumors are surrounded by immune cells, but not all of those cells help the body fight back. Some support anti-cancer immunity, while others can unexpectedly help tumors survive.