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Immune cells can become exhausted after prolonged exposure to cancer, gradually losing their ability to attack tumor cells.

People living with a severe form of asthma show subtle differences in the structure of their brains compared with people whose asthma is well controlled, according to new research presented at the European Respiratory Society (ERS) Congress in Barcelona, Spain.

Streptococcal sore throat - strep throat for short - is one of the nastier maladies of childhood, causing fever, swollen tonsils, and the namesake sore throat.

Understanding how the brain processes rewarding experiences could help researchers better understand behaviors such as overeating, as well as conditions such as anhedonia-the inability to experience pleasure, which is a common symptom of depression.

Bone repair depends on skeletal progenitor cells (SPCs) moving to injured areas and developing into bone-forming cells, but how these cells respond to their surroundings remains unclear.

In a 50-year follow-up study, men with a low cardiovascular risk in their 40s retained their functional capacity, happiness and quality of life better than others as they aged.

The latest medical innovations in cardiovascular research have been showcased by the British Heat Foundation Leicester Centre of Research Excellence.

Scorpion venom peptides show promising anti-inflammatory, antiviral, analgesic, and immunomodulatory effects, with experimental evidence suggesting that some candidates could target pathways involved in chronic liver disease and viral hepatitis. The review highlights Kv1.3-blocking peptides and antiviral compounds as potential therapeutic leads, while emphasizing that limited hepatic efficacy data, poor pharmacokinetics, immunogenicity, and manufacturing challenges must be overcome before clinical translation.

In a cross-sectional U.S. sample of 129 adults, older age was associated with greater positive and lower negative emotional well-being, alongside greater dispositional mindfulness and lower neuroticism. Lower neuroticism statistically accounted for age differences in both positive and negative well-being, while mindfulness statistically accounted for differences in negative well-being only, although the study cannot establish causality.

A UK Biobank cohort and Mendelian randomization study involving 272,475 participants linked higher circulating tyrosine with greater all-cause mortality and genetically predicted higher tyrosine with shorter lifespan. After accounting for phenylalanine, the relationship with shorter lifespan was clearest in men, while findings in women were less consistent, suggesting a potential sex-specific role for tyrosine in longevity.

The average person takes thousands of steps each day, instinctively walking heel-to-toe. Although they hardly register them, those consistent heel-first strides are more unique to humans than previously thought and allowed early hominins to walk farther more efficiently, but at the cost of higher impact forces on bones and joints, according to a new study led by a researcher at Penn State.

University of California, Davis researchers have stripped down LSD to the base features responsible for its hallucinogenic and therapeutic effects.

Three large studies together show that, although the number of people who smoke is declining, people are taking up smoking at a younger age and vaping has increased, particularly among children and younger people.

The diabetes and weight loss injection semaglutide can reduce asthma attacks by up to 40 per cent according to research presented at the European Respiratory Society (ERS) Congress in Barcelona, Spain.

Bacteria can survive antibiotics in several ways, including by pumping the drugs out of their cells before they can take effect.

Teenagers who come from households with a lower income and lower level of education are more likely to have an eating disorder, finds a new study co-led by UCL researchers.

Researchers analyzed 1,957 vaginal metagenomic samples from 1,547 pregnant women and found that bacterial community structure was strongly associated with the diversity and distribution of clinically relevant antibiotic resistance genes. Lactobacillus crispatus-dominated communities carried comparatively few acquired resistance genes, while L. iners-dominated and anaerobe-rich communities showed greater resistance diversity, with PPROM associated with broader predicted resistance profiles among ARG-positive samples.

A systematic review of 43 studies found highly heterogeneous results for GLP-1 receptor agonists across animal models and human research assessing depression-, anxiety-, and stress-related outcomes. No study directly tested these drugs as a treatment for PTSD, and the available evidence does not currently support their use for depression or PTSD, although people with metabolic dysfunction may warrant further investigation.

A systematic review of 11 studies involving 3,262 adults found that psilocybin mushroom and truffle microdosing was associated with reported improvements across areas including mental health, well-being, cognition, creativity, and social functioning. However, the evidence was methodologically weak and highly heterogeneous, the two placebo-controlled trials found no significant improvements, and inadequate adverse-event reporting means efficacy and safety remain uncertain.

A prospective study of 252 mother-child pairs found that higher combined maternal fruit and vegetable intake during pregnancy was associated with lower odds of overweight or obesity in children at age four. Total and natural fruit juice showed no association, whereas higher commercial fruit juice intake was associated with increased odds, though the authors emphasized that this finding was exploratory.