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Late-life semaglutide treatment slowed age-related physiological decline, attenuated multiple molecular hallmarks of aging, and extended median lifespan from 742 to 834 days in aged female mice. The drug reproduced many effects of calorie restriction while providing additional benefits in exploratory behavior, spatial memory, and glucose control, suggesting that some effects extend beyond reduced calorie intake alone.

A targeted perspective synthesizes epidemiological and mechanistic evidence examining how caffeine consumption during midlife may influence dementia risk later in life. The authors highlight potential roles for dose, age, CYP1A2 genotype, adenosine signaling and cultural drinking practices, while stressing that current observational evidence cannot establish causality.

In a randomized crossover study of 22 healthy, normal-weight Chinese men, consuming canola oil alone or with spinach before a high-glycemic mashed-potato meal produced flatter post-meal glucose and insulin responses than spinach alone or no preload. The effects were associated with increased GLP-1 signaling and slower gastric emptying, with the findings indicating that the unsaturated oil was the primary driver of the metabolic response.

The Sussex 4-Day Week study is a 14-week UK protocol designed to investigate how reduced working hours affect physical and mental health, wellbeing, sleep, work performance, and potential biological and psychological mechanisms. Researchers aim to combine questionnaires with actigraphy, inflammatory biomarkers, interoception testing, and brain imaging in at least 150 adults, with data collection expected to continue until 2027.

New research reveals a promising new target for treating cancer by harnessing a type of molecule previously thought to do more harm than good.

Aging does not appear to follow the same molecular script for everyone, according to an eight-year study of 335 women.

Researchers at the University of Oulu have identified alpha-1 antitrypsin as a potential target for preventing spontaneous preterm birth.

Scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed microscopic peptide droplets that deliver large amounts of gene-silencing molecules into cancer and immune cells, reducing the growth of hard-to-treat colorectal tumours by about 67 per cent in mice.

In the midst of another intense wildfire season, a new study sheds light on the risks they pose to life-sustaining dialysis care for thousands of Canadians.

Historically, cerebral palsy (CP) was linked largely to events at birth, including prematurity or temporary loss of oxygen to the brain, but research over the past decade has suggested that genetic factors contribute to CP in many children.

Level of education is the socio-economic factor most strongly associated with survival rates after acute hip surgery. This is shown in a Linköping University study of 58,000 people.

For children born with cleft lip and palate, repairing gaps in the jawbone often means waiting until they are 10 to 12 years old before undergoing invasive bone graft surgery.

Men already at risk genetically for the most common form of hair loss have a 7 percent added risk of losing their hair if they use drugs like Ozempic, Wegovy, and Zepbound for type 2 diabetes and obesity, a new study shows.

People with inflammatory bowel disease (IBD) who have several close relatives with colorectal cancer are significantly more likely to develop the disease themselves.

Emory University researchers have provided the first proof-of-concept in a nonhuman primate model for eliminating HIV-infected cells with venetoclax, a clinically approved medication for cancer.

Immune cells that normally protect the body from damage by attacking foreign or infected cells are found in the brains of patients with Alzheimer's disease and related disorders at much higher levels than in healthy brains.

A new study has used a type of machine learning called a neural network to reveal how different kinds of training can change how learning happens-both in machines, and in living brains.

Scientists have found that targeting a particular group of proteins in the uterus muscle (myometrium) can suppress human uterine contractions in laboratory studies and delay preterm birth in a preclinical model.

A review of clinical trials, observational studies, genetic analyses, and mechanistic research suggests that atrial fibrillation risk may follow a U-shaped relationship with testosterone, increasing at both low and high levels. Evidence on testosterone replacement therapy remains mixed, with researchers calling for prospective studies to determine whether mid-physiological testosterone targets and treatment formulation influence AF risk.

Among people who have a stroke in Canada, immigrants were admitted to the intensive care unit (ICU) at similar rates as long-term residents or people who were born in Canada, but they were more likely to have longer stays in the ICU, according to a study published September 2, 2026, in Neurology, the medical journal of the American Academy of Neurology.