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Researchers have identified the best dosage for each ADHD medication using data from thousands of people with the condition.

A meta-analysis of 32 studies and 43,618 adults presented at this year's European Congress on Obesity in Istanbul, Turkey (12-15 May) shows that use of new classes of obesity drugs for weight loss is associated with a clinically relevant drop in blood pressure (BP): a 0.34 mmHg reduction in systolic BP per 1\% weight loss.

A Kaiser Permanente study of nearly 8,000 men shows that in mid- to late 2024, mpox was far more common among men who have sex with men than previously thought. Individuals without symptoms accounted for most infections and likely played a prominent role in transmission, contrary to prior assumptions that people had to be symptomatic to spread the disease.

Research reveals a predictive model for early mobility limitations, emphasizing the impact of the Mediterranean diet and muscle power on aging health.

Higher-quality plant-based diets were associated with more favorable cardiometabolic biomarkers in pregnant U.S. women, especially higher HDL-C and lower TG/HDL-C ratio. Indices that emphasized healthy plant foods, rather than simply penalizing animal foods, showed the strongest links with insulin resistance and lipid markers.

In 2021, neurological diseases affected 3.40 billion individuals worldwide, corresponding to 43.1 % of the global population. In China, rapid demographic shifts and lifestyle changes have contributed to a continued rise in the burden of stroke, dementia, and Parkinson's disease-a trend expected to persist.

Basilar trunk artery aneurysms (BTAs) are among the rarest and most complex types of brain aneurysms, occurring in a critical vessel that supplies blood to the brainstem. Because of their location and low incidence, there has been limited research guiding how best to treat them, leaving neurosurgeons with few large datasets to inform clinical decisions.

Although cancer immunotherapy has transformed treatment by harnessing the immune system to eliminate tumors, only a small subset of patients benefit. Many solid tumors remain "cold," characterized by poor immune cell infiltration and resistance to immune checkpoint blockade (ICB).

Researchers have introduced a novel diagnostics method that can more sensitively detect gene fusions in B-cell acute lymphoblastic leukemia (B-ALL), the most common type of pediatric cancer, compared to other publicly available fusion detection algorithms.

Researchers from A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new method, called 'sm-PORE-cupine', to study individual RNA molecules and reveal how their structures influence gene regulation, a fundamental process that affects how cells function in health and disease.

A healthy brain may help protect thinking and memory skills from the early effects of Alzheimer's disease, a new study has found.

Blood tests to detect potential signs of prostate cancer likely reduce the risk of dying from prostate cancer, an updated Cochrane review finds. This is a shift from the previous version of the review, which did not find sufficient evidence that screening reduced prostate cancer deaths.

Dietary supplements are widely used by people with Parkinson’s disease, but this review finds that none have yet been proven to slow disease progression. Biotics, nicotinamide riboside, and omega-3 fatty acids combined with vitamin E show the most promise, but larger, longer, and better-designed trials are needed.

The Nature study introduces “Sleep Chart,” a framework linking self-reported sleep duration with 23 biological aging clocks derived from MRI, plasma proteomics, and metabolomics. Across UK Biobank participants, the lowest biological age gaps generally appeared between 6.4 and 7.8 hours of sleep, while shorter and longer sleep were associated with higher disease and mortality risk.

A 2020 NEJM study of the 2018 to 2019 Epuyén outbreak showed that Andes virus spread from one zoonotic introduction into four generations of human infection, causing 34 cases and 11 deaths. The findings are newly relevant after WHO reported an ANDV cluster linked to the MV Hondius cruise ship, where close indoor exposure may have enabled onboard human-to-human transmission.

Perioperative medicine is emerging as a transformative, comprehensive, system-wide approach to patient care before, during, and after surgery – that reduces complication rates and hospital days, provides better health outcomes, and improves health system performance, according to a special article in the Online First edition of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).

A study led by a University of Louisville School of Medicine pediatrics and child neurology researcher reveals how a specific signaling mechanism in microglia, the brain's immune cell, can regulate anxiety and grooming behaviors. These behaviors are core symptoms of autism and obsessive-compulsive spectrum disorders.

Increasing bone density in patients with a rare genetic condition that causes bones to break easily does not prevent fractures, a large clinical trial has found.

Researchers at the Stanford School of Medicine have found that ethnicity and geography may influence human molecular makeup - from metabolism and immunity to gut microbiota and biological aging.

Materials scientists have designed brain-stimulating contact lenses that are as effective as Prozac at treating depression in mice. The soft, transparent contact lenses have in-built electrodes that deliver mild electrical signals to the brain via the retina to stimulate specific brain regions associated with depression.