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A global analysis of GBD 2023 data found that alcohol-attributable liver cancer mortality increased modestly from 1990 to 2023, while mortality from alcohol-attributable cirrhosis, alcoholic cardiomyopathy, and alcohol use disorders declined. Liver cancer mortality shifted from a pre-pandemic decline to an increase during 2020–2023, particularly among women, although the researchers cautioned that the ecological analysis cannot establish that pandemic-related changes caused the reversal.

A global literature review and geostatistical modeling study estimated the burden of snake envenoming and deaths across countries, accounting for differences in surveillance, underreporting, socioeconomic conditions, and environmental factors. The analysis highlights major gaps in epidemiological data and provides updated country- and regional-level estimates to help guide prevention, antivenom access, surveillance, and healthcare resources.

University of Missouri researchers are advancing a promising new approach to treating a serious heart condition that affects millions of older adults worldwide.

Researchers have created a detailed map of childhood Crohn's disease before and after treatment to help understand progression of the disease.

Smartwatches can significantly overestimate how many calories people burn during exercise, and their calorie estimates become less accurate as body fat increases, according to a new Florida International University study.

Hyperventilating. Breath holding until they turn blue. This abnormal breathing is frequent and disturbing in people with Rett syndrome, a rare genetic disease.

Patients with type 2 diabetes who have high blood glucose levels, low body weight, or a history of ketoacidosis are at increased risk of developing this serious condition when treated with so-called SGLT2 inhibitors.

A new Cochrane review finds very low-quality evidence on lumbar supports for chronic low back pain, meaning that no strong recommendations can be made either for or against their use.

A prospective UK Biobank study of 171,818 adults found that greater estimated exposure to foods containing flavorings, coloring agents, and sweeteners was dose-dependently associated with a higher risk of incident depression over 10.7 years. The findings suggest that specific markers, rather than ultra-processed foods uniformly, may help explain associations between UPF consumption and depression risk.

Researchers analyzed 646 children aged 2–8 years and their 563 mothers to examine whether maternal folic acid supplementation before conception was associated with childhood behavioral difficulties. Preconception supplementation was associated with a 34% lower risk of peer relationship problems, while no significant associations were found for total behavioral difficulties, emotional, conduct, hyperactivity/inattention, or prosocial problems.

Researchers analyzed dietary and sleep data from 5,975 Japanese adults to examine whether seafood, EPA, and DHA intake at different meal occasions was associated with chronotype and social jetlag. Higher intake at breakfast showed the strongest association with earlier sleep timing and less social jetlag, although the cross-sectional design cannot establish whether dietary timing influences sleep patterns or vice versa.

Researchers at Helmholtz Munich, the Heidelberg Faculty of Medicine at Heidelberg University, the German Center for Diabetes Research (DZD) and the Technical University of Munich (TUM), have identified a previously unknown mechanism that can drive cancer cachexia – a wasting process in the body that primarily affects muscle and fat tissue.

The Icahn School of Medicine at Mount Sinai has received a $4.1 million grant from the National Heart, Lung, and Blood Institute, part of the National Institutes of Health, to study how everyday exposures affect the health of people with sickle cell disease.

Senescent cells - cells that have stopped dividing but remain metabolically active - can accumulate with age and contribute to chronic inflammation and tissue dysfunction

A region of the brain called the striatum is critical for many cognitive and motor functions, including decision-making, control of movement, habit formation, and processing of reward.

The way cancer-causing proteins accumulate in tumours may influence how effectively a promising new generation of medicines can remove them, a study suggests.

Obesity-related metabolic liver disease affects hundreds of millions of people worldwide, but only some fraction of those livers develop scarring, become inflamed, and eventually fail. University of Utah researchers have identified a protein, EFHD1, that appears to drive that transition by triggering an out-of-place antiviral immune response.

Jessica Thaxton, PhD, MsCR, associate professor in the Department of Cell Biology and Physiology at the UNC School of Medicine and co-leader of the Cancer Cell Biology Research Program at UNC Lineberger Comprehensive Cancer Center, has been awarded a prestigious $700,000 grant from the Mathers Foundation to support research into the role of the endoplasmic reticulum in T-cell metabolism and cancer development.

The Patient-Centered Outcomes Research Institute (PCORI) has announced a $13 million funding award to the University of North Carolina at Chapel Hill over five years to study innovative symptom management interventions for patients with rare cholestatic liver diseases.

A commonly used systemic antifungal medication may help reduce symptoms in a subset of patients with inflammatory bowel disease (IBD) by restoring a healthier gut microbiome, according to a preliminary study by Weill Cornell Medicine investigators.