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A TAVI-first strategy was noninferior to a PCI-first strategy after one years' follow-up, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in the New England Journal of Medicine.

A single dose of psilocybin produced a lasting increase in sociability for at least two weeks in Cntnap2-knockout mice with social deficits, while it did not enhance sociability overall in mice with normal social behavior. The effect required 5-HT2A receptor activation and persisted when psilocybin was administered under light anesthesia, suggesting that wakefulness during the drug’s acute effects was not necessary for this behavioral response.

Early initiation of statins after diagnosis of type 2 diabetes was associated with a lower risk of dementia, according to a study presented today at ESC Congress 2026 and published in The Lancet Regional Health – Europe.

Better cardiovascular health, measured using Life’s Essential 8, was associated with a lower risk of mild cognitive impairment among people with diabetes after accounting for genetic susceptibility. Associations with dementia varied by genetic risk, while higher LE8 scores were also linked to greater gray matter volume and lower white matter hyperintensity volume.

In an exploratory study of 137 Australian adults, skin yellowness measured by reflectance spectroscopy was associated with combined fruit and vegetable intake, fruit intake alone, total carotenoid intake, body fat percentage and skin color. The findings suggest skin measurements could provide an objective dietary biomarker, but the researchers caution that skin color, ethnicity and other individual characteristics may influence how the measurements are interpreted.

Many breast cancer survivors whose treatment caused them to develop problems with their heart function can safely stop their medication after their heart recovers and most won't need to continue treatment long-term, according to a study funded by the British Heart Foundation and presented at the European Society of Cardiology Congress in Munich.

Remotely delivered exercise-based cardiac rehabilitation, when added to center-based programs, resulted in a similar number of completed sessions as center-based programs only, according to results presented in a Hot Line session today at ESC Congress 2026.

A rapid pathway for diagnosing heart attacks in the emergency department (ED) was as safe as a slower pathway but neither reduced the length of time patients spent in the ED nor increased direct discharge from the ED.

Functional coronary angiography significantly reduced cardiovascular events and improved safety compared with conventional angiography in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease.

Silent atherosclerosis was detectable from early adulthood and showed sex-specific patterns of growth with age, according to results from the REACT study presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in the New England Journal of Medicine.

Atherosclerosis, the process underlying most cardiovascular diseases, begins long before the first symptoms appear.

Researchers have uncovered early molecular warning signs of inflammatory bowel disease, revealing the condition can begin before symptoms appear and continue silently even when patients appear well.

Cardiovascular disease remains a major global health challenge, causing millions of deaths each year and imposing substantial healthcare costs. Early, accurate diagnosis is critical for improving outcomes and enabling timely intervention.

Every year, hundreds of thousands of older Americans recover from hip and knee replacement surgery at home. For many, that recovery depends on timely access to physical or occupational therapy after leaving the hospital.

Australian researchers are challenging decades-old assumptions about brain cancer treatment in a bid to make radiation therapy more effective against tumors, while reducing damage to healthy tissue.

Brain diseases, including dementia, have long been studied using experimental animals such as mice. However, differences between the human and animal genomes have raised concerns that some disease mechanisms may not be fully explained by conventional animal models.

A new research paper was published in Volume 17 of Oncotarget on August 19, 2026, titled "Incidence of KRAS G12C mutations in genitourinary malignancies; emerging target in precision medicine."

New research to be presented at the Annual Meeting of The European Association for the Study of Diabetes (EASD) in Milan, Italy (Sept 28 – Oct 2) estimates the number of people living with type 1 diabetes (T1D) worldwide will increase by 29% from 9.4 million in 2025 to 12.1 million in 2049.

In their quest to understand how cancers take root, grow and spread, scientists have for the past half-century explored the genetic aberrations and microenvironmental peculiarities of tumors and their constituent cells.

Millions of people worldwide are affected by diseases that cause scarring of the lungs, often leading to breathing difficulties and reduced quality of life.