Feed aggregator

Predicting whether a healthy 45-year-old will struggle to climb stairs or walk a decade later has long been a challenge for geriatric medicine.

Targeted protein degradation has become one of the most promising strategies in modern drug discovery, enabling scientists to eliminate disease-causing proteins instead of merely blocking them.

Diabetes is the most common and serious chronic disease worldwide, characterized by insufficient insulin to maintain proper blood glucose levels.

Chromosomes carry genetic information for biological sex, which generally assigns women two X chromosomes and men XY chromosomes.

A large retrospective cohort study of adult female breast cancer patients found that GLP-1 receptor agonist use was associated with better all-cause survival and recurrence-free survival in patients with obesity or type 2 diabetes. The strongest associations were seen versus non-use in obesity and versus insulin or metformin in type 2 diabetes, while comparisons with SGLT2 inhibitors were less consistent and require further study.

A JAMA Network Open study found that the US recorded 12.7 million excess deaths compared with 17 peer high-income countries between 1999 and 2022. Circulatory and metabolic diseases drove much of the burden, while drug poisonings, alcohol-related deaths, and suicide sharply widened the gap among younger Americans.

A macroeconomic modelling study across 190 countries and territories estimates that diabetes could reduce global economic output by INT$5.177 trillion between 2021 and 2050. Most projected losses stem from diabetes-related disability and morbidity, with high-income countries facing the largest dollar losses and low- and middle-income countries carrying most of the disease burden.

Older adults in Colorado were drawn to edible cannabis mainly to manage sleep problems, pain, anxiety, or depression, often after concerns about conventional medicines or limited relief from other treatments. Most participants preferred THC-CBD combination products, but they remained uncertain about dosing, impairment, effectiveness, and how to choose the right cannabinoid ratio.

An international research group recently demonstrated that the antibody NG101 promotes the regeneration of damaged spinal cord tissue.

New research, from King's College London and the University of Porto, has mapped the histamine system in the brain. Histamine, a molecule more commonly associated with allergies, plays a separate but poorly understood role in brain function.

Researchers from the Hebrew University of Jerusalem and the Weizmann Institute of Science have identified a previously unrecognized defense mechanism in the intestine, showing that intestinal stem cells can actively respond to Salmonella infection and help protect the gut from bacterial invasion.

Girls born to mothers with higher insulin resistance during the third trimester are more likely to have more abdominal fat at age 7, according to research presented at the 28th European Congress of Endocrinology in Prague.

MOZAIC leverages deep learning to optimize fecal microbiota transplantation, enhancing treatment efficacy through precise donor-recipient microbiome matching.

Research shows FoMO influences addictive eating, with anxiety heightening reward-driven cravings for ultra-processed foods and compulsive overeating.

A University of California, Riverside preclinical study is shedding light on a long-observed but poorly understood phenomenon: chronic cannabis users tend to have lower body weight and a reduced risk of developing type 2 diabetes, despite the drug's well-known tendency to increase appetite.

As a highly differentiated sensory organ, the maintenance of the eye's physiological functions relies on rigorous metabolic regulation.

Neurons and white blood cells differ greatly in shape, function, and location within the body. However, researchers at the University of São Paulo (USP) in Brazil discovered that certain genes are equally dysregulated in both cell types in people with depression.

Scientists' discovery of a molecular "switch" that activates an energy‑burning pathway in mice has the potential to lead to new treatments for bone disease.

Regularly taking part in arts activities such as reading, listening to music or visiting a gallery or museum may slow the pace of biological aging, suggests a new study by University College London (UCL) researchers.

A New York City cohort study found that few women with postpartum-onset diabetes received guideline-recommended A1C monitoring over three years. Non-Hispanic Black women and mothers with more children faced lower monitoring rates, while Medicaid coverage was linked to better follow-up.