The Effect of Direct Electric Current on Some Parameters of Human Blood Coagulation

ORIGINAL ARTICLE
Anzhela Z. Galstyan, Zoya Kh. Paronyan, Narine S. Piloyan, Hasmik A. Stepanyan, Davit A. Poghosyan, Lusine R. Arakelyan, Torgom Ye. Seferyan

 
For citation: Galstyan AZ, Paronyan ZKh, Piloyan NS, Stepanyan HA, Poghosyan DA, Arakelyan LR, Seferyan TYe. The Effect of Direct Electric Current on Some Parameters of Human Blood Coagulation. International Journal of Biomedicine. 2025;15(4):741-745. doi:10.21103/Article15(4)_OA16
 
Originally published December 5, 2025

Abstract: 

Background: Direct current (DC) is increasingly used in medical applications, yet its effects on blood plasma hemostasis remain underexplored. This study systematically examines the effects of DC exposure on key coagulation parameters and plasma pH, highlighting their potential physiological relevance and implications for electrotherapeutic strategies.
Methods and Results: The experiments used a pooled plasma sample from healthy donors, which was subjected to electrolysis using platinum point electrodes and a DC with a voltage range of 11-19V. A number of parameters characterizing plasma hemostasis were measured to assess the coagulation process, including recalcification time, prothrombin time, thrombin time, activated partial thromboplastin time, international normalized ratio index, fibrinogen level, pH, and absorbed current strength. Experimental data showed that, with increasing current voltage during electrolysis, plasma coagulation time exhibits nonlinear changes, some parameters change significantly, and plasma hemostasis slows down beyond a certain current voltage threshold. The obtained data can be helpful for both therapeutic and other research in this field.

Keywords: 
plasma • hemostasis • fibrinogen • anticoagulant action
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Received September 30, 2025.
Accepted November 8, 2025.
©2025 International Medical Research and Development Corporation.