For citation: AbdElrahim E, Al-Malki RJ, Al-Kathiri RA, Al-Thobaity JA, Al-Kaabi SA, Al-Withainani IS, Elkhader ME, Osman BAH. Ultrasound Evaluation of Renal Measurements in Type 1 Diabetes Patients: Impact of Disease Duration. International Journal of Biomedicine. 2026;16(2):197-200. doi:10.21103/Article16(2)_OA6
Originally published June 5, 2026
Background: Type 1 diabetes mellitus (T1DM) is a chronic metabolic disorder associated with progressive renal complications, often leading to diabetic nephropathy. Early detection of renal morphological changes is essential for prevention and management. This study aimed to evaluate the impact of T1DM duration on renal size and morphology using ultrasound, with a focus on kidney length, width, thickness, and cortical characteristics.
Methods and Results: A retrospective cross-sectional study was conducted on 94 patients with T1DM in Taif, Saudi Arabia, between November 2024 and May 2025. Patients of both sexes, aged 1–70 years, underwent renal ultrasound in accordance with standard hospital protocols. Kidney dimensions (length, width, thickness) and cortical echogenicity were measured and compared across different disease durations and age groups.
Slight renal enlargement was observed in 73.7% of patients, predominantly in younger age groups (10–20 years), while 26.3% demonstrated slight renal atrophy, more frequent among older patients. The length and width of the kidneys gradually decreased 10 years after disease onset, reflecting progressive loss of parenchyma. The duration of longer diabetes appears to increase the likelihood of kidney atrophy, especially in older patients.
Conclusion: Ultrasound is a non-invasive and effective tool for monitoring renal morphological changes in patients with T1DM. Early-stage kidney hypertrophy trend appears to progress toward atrophy with longer disease duration, especially in older patients. underscoring the importance of routine renal monitoring to identify early diabetic nephropathy and guide timely intervention.
- Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Lernmark Å, Metzger BE, Nathan DM, Kirkman MS. Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. Diabetes Care. 2023 Oct 1;46(10):e151-e199. doi: 10.2337/dci23-0036. PMID: 37471273; PMCID: PMC10516260.
- American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014 Jan;37 Suppl 1:S81-90. doi: 10.2337/dc14-S081. PMID: 24357215.
- International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care. 2009 Jul;32(7):1327-34. doi: 10.2337/dc09-9033. Epub 2009 Jun 5. PMID: 19502545; PMCID: PMC2699715.
- Meijnikman AS, De Block CEM, Dirinck E, Verrijken A, Mertens I, Corthouts B, Van Gaal LF. Not performing an OGTT results in significant underdiagnosis of (pre)diabetes in a high risk adult Caucasian population. Int J Obes (Lond). 2017 Nov;41(11):1615-1620. doi: 10.1038/ijo.2017.165. Epub 2017 Jul 19. PMID: 28720876.
- Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002 Feb 7;346(6):393-403. doi: 10.1056/NEJMoa012512. PMID: 11832527; PMCID: PMC1370926.
- Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M; Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001 May 3;344(18):1343-50. doi: 10.1056/NEJM200105033441801. PMID: 11333990.
- Diabetes Prevention Program Research Group. HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention program: a randomized clinical trial. Diabetes Care. 2015 Jan;38(1):51-8. doi: 10.2337/dc14-0886. Epub 2014 Oct 21. PMID: 25336746; PMCID: PMC4274777.
- Echouffo-Tcheugui JB, Selvin E. Prediabetes and What It Means: The Epidemiological Evidence. Annu Rev Public Health. 2021 Apr 1;42:59-77. doi: 10.1146/annurev-publhealth-090419-102644. Epub 2021 Dec 23. PMID: 33355476; PMCID: PMC8026645.
- Chadha C, Pittas AG, Lary CW, Knowler WC, Chatterjee R, Phillips LS, Aroda VR, Lewis MR, Pratley R, Staten MA, Nelson J, Rasouli N, Brodsky I; D2d Research Group. Reproducibility of a prediabetes classification in a contemporary population. Metabol Open. 2020 Mar 7;6:100031. doi: 10.1016/j.metop.2020.100031. PMID: 32812912; PMCID: PMC7424833.
- Tonneijck L, Muskiet MH, Smits MM, van Bommel EJ, Heerspink HJ, van Raalte DH, Joles JA. Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment. J Am Soc Nephrol. 2017 Apr;28(4):1023-1039. doi: 10.1681/ASN.2016060666. Epub 2017 Jan 31. PMID: 28143897; PMCID: PMC5373460.
- Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003 Jan;26 Suppl 1:S5-20. doi: 10.2337/diacare.26.2007.s5. PMID: 12502614.
- Klein KR, Walker CP, McFerren AL, Huffman H, Frohlich F, Buse JB. Carbohydrate Intake Prior to Oral Glucose Tolerance Testing. J Endocr Soc. 2021 Mar 29;5(5):bvab049. doi: 10.1210/jendso/bvab049. PMID: 33928207; PMCID: PMC8059359.
- Mottl AK, Alicic R, Argyropoulos C, Brosius FC, Mauer M, Molitch M, Nelson RG, Perreault L, Nicholas SB. KDOQI US Commentary on the KDIGO 2020 Clinical Practice Guideline for Diabetes Management in CKD. Am J Kidney Dis. 2022 Apr;79(4):457-479. doi: 10.1053/j.ajkd.2021.09.010. Epub 2022 Feb 7. PMID: 35144840; PMCID: PMC9740752.
- Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Int. 2022 Nov;102(5S):S1-S127. doi: 10.1016/j.kint.2022.06.008. PMID: 36272764.
- Afkarian M, Zelnick LR, Hall YN, Heagerty PJ, Tuttle K, Weiss NS, de Boer IH. Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014. JAMA. 2016 Aug 9;316(6):602-10. doi: 10.1001/jama.2016.10924. PMID: 27532915; PMCID: PMC5444809.
Download Article
Received April 15, 2026.
Accepted May 25, 2026.
© 2026 The Author(s). International Journal of Biomedicine is published by IMRDC.
This is an open access article under the CC BY-NC-ND 4.0 license.




